| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this research project, the cartilaginous circadian clocks were studied. The obvious circadian rhythms of reporter gene activity were confirmed in both PERIOD2::Luciferase knock-in mouse and Per2-dLuc transgenic (TG) rats. When vertebral cartilage was collected and cultured from neonates and juvenile Per2-dLuc TG rats, peak phases of the bioluminescence rhythm were delayed according to age. These results suggest that not only mice but also rats are a good model for studying the cartilaginous circadian clock and the circadian clock phases are changes according to the cartilage development.
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