Mechanisms for production of reactive oxygen species in chondrocytes and synoviocytes derived from patients with rheumatoid arthritis and their involvement in joint destruction
Project/Area Number |
17K11032
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | Toho University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
中川 晃一 東邦大学, 医学部, 教授 (30400823)
|
Project Period (FY) |
2017-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 関節リウマチ / 酸化ストレス / 寛解予測 / バイオマーカー / 関節破壊 / 活性酸素種 / トシリズマブ / 整形外科学 |
Outline of Final Research Achievements |
To verify whether serum levels of reactive oxygen metabolites (ROM) are predictive of future clinical remission in patients with rheumatoid arthritis (RA) receiving tocilizumab (TCZ) therapy. A total of 46 patients with RA receiving TCZ therapy were enrolled in this study. Patients were divided into remission and non-remission groups based on DAS28 at 52 weeks. Associations between serum levels of ROM, CRP, and MMP-3 at 4 and 12 weeks and the DAS-remission at 52 weeks were investigated. There were no significant differences in CRP and MMP-3 between DAS-remission and non-remission groups at 12 weeks. However, ROM in DAS-remission group were significantly lower than those in the non-remission group. For ROM, an AUC of the ROC curve was 0.735 and the cut-off value was 305.5 U.Carr (sensitivity: 70.0%, specificity: 72.2%). A multivariate logistic regression analysis revealed that ROM at 12 weeks was associated with DAS-remission at 52 weeks (OR: 6.067, 95% CI: 1.305-28.203).
|
Academic Significance and Societal Importance of the Research Achievements |
IL-6受容体抗体のトシリズマブ(TCZ)は関節リウマチ(RA)患者に広く使用されているバイオ製剤である。しかしながら、TCZはCRPなどの急性反応物質の産生を強力に抑制する。このため実臨床ではCRPと臨床症状との乖離が見られることがあり、寛解予測のためのバイオマーカーの開発が望まれている。 本研究の結果、TCZ治療開始後12週における血中酸化ストレスマーカーであるROMが52週のDAS寛解を予測することが明らかとなった。治療効果判定にしばしば用いられるCRP, MMP-3はDAS寛解とは関連がなかったことから、ROMはTCZ治療早期寛解予測のバイオマーカーとして有用と考えられる。
|
Report
(5 results)
Research Products
(39 results)
-
-
[Journal Article] Surgical Treatment for Atlantoaxial Rotatory Fixation in an Adult With Spastic Torticollis: A Case Report2020
Author(s)
Akiyama Y, Takahashi H, Saito J, Aoki Y, Nakajima A, Sonobe M, Akatsu Y, Yamada M, Yanagisawa K, Shiga Y, Inage K, Orita S, Eguchi Y, Maki S, Furuya T, Akazawa T, Koda M, Yamazaki M, Ohtori S, Nakagawa K
-
Journal Title
J Clin Neurosci
Volume: 20
Pages: 30046-30046
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] 多剤耐性淋菌による化膿性膝関節炎の1例2020
Author(s)
中野志保, 赤津頼一, 中島 新, 園部正人, 高橋 宏, 齋藤淳哉, 山田 学, 戸口 郁, 秋山友紀, 岩井達則, 柳澤啓太, 中川晃一
-
Journal Title
日本関節病学会誌
Volume: 39
Pages: 101-104
NAID
Related Report
Peer Reviewed
-
[Journal Article] Serum Oxidative Stress Influences Neurological Recovery After Surgery to Treat Acutely Worsening Symptoms of Compression Myelopathy: A Cross-Sectional Human Study2019
Author(s)
Takahashi H, Aoki Y, Saito J, Nakajima A, Sonobe M, Akatsu Y, Taniguchi S, Yamada M, Koyama K, Akiyama Y, Shiga Y, Inage K, Orita S, Eguchi Y, Maki S, Furuya T, Akazawa T, Koda M, Yamazaki M, Ohtori S, Nakagawa K
-
Journal Title
BMC Musculoskelet Disord
Volume: 20
Issue: 1
Pages: 589-589
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Serum levels of reactive oxygen metabolites at 12 weeks during tocilizumab therapy are predictive of 52 weeks-disease activity score-remission in patients with rheumatoid arthritis2019
Author(s)
Nakajima A, Terayama K, Sonobe M, Aoki Y, Takahashi H, Akatsu Y, Saito J, Taniguchi S, Yamada M, Kubota A, Nakagawa K
-
Journal Title
BMC Rheumatol
Volume: 3
Issue: 1
Pages: 48-48
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Superior graft maturation after anatomical double-bundle anterior cruciate ligament reconstruction using the transtibial drilling technique compared to the transportal technique2019
Author(s)
Saito M, Nakajima A, Sonobe M, Takahashi H, Akatsu Y, Inaoka T, Iwasaki J, Morikawa T, Watanabe A, Aoki Y, Sasho T, Nakagawa K
-
Journal Title
Knee Surg Sports Traumatol Arthrosc
Volume: 27
Issue: 8
Pages: 2468-2477
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Intradural metastasis to the cauda equina found as the initial presentation of breast cancer: a case report.2019
Author(s)
Koyama K, Takahashi H, Inoue M, Okawa A, Nakajima A, Sonobe M, Akatsu Y, Saito J, Taniguchi S, Yamada M, Yamamoto K, Aoki Y, Furuya T, Koda M, Yamazaki M, Ohtori S, Nakagawa K
-
Journal Title
J Med Case Rep
Volume: 13
Issue: 1
Pages: 220-220
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
[Journal Article] Surgical treatment for dropped head syndrome with cervical spondylotic amyotrophy: a case report2018
Author(s)
Taniguchi S, Takahashi H, Aoki Y, Nakajima A, Terajima F, Sonobe M, Akatsu Y, Yamada M, Furuya T, Koda M, Yamazaki M, Ohtori S, Nakagawa K
-
Journal Title
BMC Res Notes
Volume: 11
Issue: 1
Pages: 500-500
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Axonal damage is remarkable in patients with acutely worsening symptom of compression myelopathy: biomarkers in cerebrospinal fluid samples.2017
Author(s)
Takahashi H, Aoki Y, Nakajima A, Sonobe M, Terajima F, Saito M, Miyamoto T, Koyama K, Yamamoto K, Furuya T, Koda M, Ohtori S, Yamazaki M, Nakagawa K.
-
Journal Title
Eur Spine J
Volume: Epub ahead of print
Issue: 8
Pages: 1824-1830
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-