| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The purpose of this study,(1) We evaluated the effect of the estrogen-deficient state on tendon-to-bone healing after rotator cuff repair in an ovariectomized rat model.(2) The morphological differences between postnatal and adult tendon insertion in terms of the ultrastructural cellular properties were clarified. In this study, we showed that (1) The estrogen-deficient state by ovariectomy, compared with control rats, led to decreased biomechanical properties and poor development of chondroid tissue that influenced the repair of the tendon insertion after surgery.(2) The present study successfully used FIB/SEM tomography to clarify the differences in morphology and cellular structural properties between postnatal and adult tendon insertions.
These findings can aid in determining how to regenerate a normal tendon insertion in the repaired tendon-bone interface after rotator cuff repair.
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