| Project/Area Number |
17K11056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Kanmura Yuichi 鹿児島大学, 医歯学域医学系, 教授 (30211189)
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| Co-Investigator(Kenkyū-buntansha) |
森山 孝宏 鹿児島大学, 医歯学域鹿児島大学病院, 講師 (20593651)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肺血症 / 急性腎障害 / ランジオロール / ミトコンドリア機能 / TNF-α / 酸素消費量 / 敗血症性腎障害 / ミトコンドリア / アドレナリン受容体 / 炎症性サイトカイン / 敗血症性腎症 / βブロッカー |
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| Outline of Final Research Achievements |
Adrenoceptors have been shown to play an important role in the development of renal injury. Inflammatory reaction and oxidative stress greatly influence pulmonary nephropathy, and it was revealed that landiolol, a beta-receptor antagonist, exerts renal protective effects. In renal disorders, anti-inflammatory and antioxidant effects have been found to have organ-protecting effects, so we will focus on these points and lead to drug discovery.
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| Academic Significance and Societal Importance of the Research Achievements |
肺血症腎障害は現在有効な治療法が確立していない。今回の研究ではアドレナリン受容体が病態に大きく関与していることが明らかとなった。今後の治療薬や更なる病態解明に貢献したと考えられた。
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