| Project/Area Number |
17K11077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Osaka University |
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Principal Investigator |
Iguchi Naoya 大阪大学, 医学系研究科, 特任講師(常勤) (00372623)
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| Co-Investigator(Kenkyū-buntansha) |
内山 昭則 大阪大学, 医学系研究科, 准教授 (00324856)
藤野 裕士 大阪大学, 医学系研究科, 教授 (50252672)
酒井 佳奈紀 大阪大学, 医学系研究科, 特任助教(常勤) (90647504)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腎髄質酸素分圧 / 急性腎傷害 / 心不全 |
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| Outline of Final Research Achievements |
Our recent findings have revealed that（1）The renal medulla is susceptible to hypoxia during cardiopulmonary bypass and renal medullary hypoxia may contribute to post-operative acute kidney injury,（2）General anesthesia markedly reduced global renal blood flow and regional kidney perfusion, these effects were greater with volatile anesthesia than intravenous anesthesia, （3）Diuretics rapidly restored medullary PO2 to pre-septic levels.
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| Academic Significance and Societal Importance of the Research Achievements |
日常臨床で心不全患者に通常用いられている人工心肺、全身麻酔薬、利尿薬について腎への影響を詳細に検討した。いずれもが急性腎傷害発症に関与する腎髄質へ大きな影響があることが分かった。急性腎傷害は患者予後や医療経済にも大きな影響を与える課題であり、心不全患者の急性腎傷害に関する本研究成果は、今後の心不全患者管理や予後改善に寄与すると考えられる。
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