| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Oxidative stress was found to be associated with postoperative delirium, which occurs more frequently after cardiovascular surgery. Furthermore, delirium was more likely to develop in elderly patients over 75 years of age if they had a greater degree of reduction in serum antioxidant vitamin C or a more severe inflammatory response immediately after the completion of surgery. Thus, for patients over 75 years of age undergoing cardiovascular surgery, aggressive intravenous administration of vitamin C or steroids may help control postoperative delirium if vitamin C is significantly depleted at the end of surgery.
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