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Elucidation of the pathology concerning gestational hyprtension by microRNA and its application to gene therapy

Research Project

Project/Area Number 17K11097
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionKansai Medical University

Principal Investigator

NAKAJIMA Yasufumi  関西医科大学, 医学部, 教授 (70326239)

Co-Investigator(Kenkyū-buntansha) 中畑 克俊  関西医科大学, 医学部, 講師 (70332971)
中山 力恒  京都府立医科大学, 医学(系)研究科(研究院), 助教 (90568198)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords敗血症 / マイクロRNA / 遺伝子治療
Outline of Final Research Achievements

We used the same miRNA as reported significantly changed in placenta and plasma from the previous study of patients with gestational hypertension in cell culture study. By injecting miRNA-specific mimic and inhibitor in HUVEC and HMEC-1 cell with electroporation, we have confirmed the changes in target mRNA and protein to the specific miRNA.
We also started the clinical study in patients with gestational hypertension. Outsourced research is underway of investigating comprehensive microRNA analysis.

Academic Significance and Societal Importance of the Research Achievements

妊娠高血圧症候群等のCommon Disease(頻度の高い疾患)は、遺伝リスクと環境リスクの組み合わせにより起こると考えられており、その割合は疾患ごとに違っている。miRNAは環境的な要因として、種々の侵襲により発現が上昇し、また遺伝的な要因としてmiRNAに遺伝子多系があることも知られている。1つのmiRNAが複数の遺伝子の発現に関与していることから、今まで1つのタンパク質の発現変化で説明が出来なかったCommon Diseaseの病態解明、バイオマーカー、治療薬としてmiRNAの解析は期待できる。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (26 results)

All 2021 2020 2019 2018 2017

All Journal Article (19 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 19 results,  Open Access: 9 results) Presentation (5 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Impact of Permissive Hypoxia and Hyperoxia Avoidance on Clinical Outcomes in Septic Patients Receiving Mechanical Ventilation: A Retrospective Single-Center Study2021

    • Author(s)
      Nishimoto K, Umegaki T, Ohira S, Soeda T, Anada N, Uba T, Shoji T, Kusunoki M, Nakajima Y, Kamibayashi T.
    • Journal Title

      BioMed research international

      Volume: 2021:7332027 Issue: 1 Pages: 7332027-7332027

    • DOI

      10.1155/2021/7332027

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Paraplegia After Open Surgical Repair Versus Thoracic Endovascular Aortic Repair for Thoracic Aortic Disease: A Retrospective Analysis of Japanese Administrative Data2021

    • Author(s)
      Umegaki T, Kunisawa S, Nishimoto K, Nakajima Y, Kamibayashi T, Imanaka Y.
    • Journal Title

      Journal of cardiothoracic and vascular anesthesia

      Volume: Online ahead of print. Issue: 4 Pages: 2021-2021

    • DOI

      10.1053/j.jvca.2021.07.043

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difference in Intraventricular Vortex Between the Single Right Ventricle and Single Left Ventricle2021

    • Author(s)
      Akiyama K, Itatani K, Wu IY, Tachibana Y, Obata Y, Nakajima Y, Yamagishi M, Takayama H, Sawa T.
    • Journal Title

      Journal of cardiothoracic and vascular anesthesia

      Volume: 35(7) Issue: 7 Pages: 2242-2242

    • DOI

      10.1053/j.jvca.2020.11.008

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasound-guided dynamic needle tip positioning versus conventional palpation approach for catheterisation of posterior tibial or dorsalis pedis artery in infants and small children2021

    • Author(s)
      akeshita J, Tachibana K, Nakayama Y, Nakajima Y, Hamaba H, Yamashita T, Shime N.
    • Journal Title

      Br J Anaesth. 2021 Apr;126(4):e140-e142.

      Volume: 126 Issue: 4 Pages: e140-e142

    • DOI

      10.1016/j.bja.2020.11.033

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ultrasound-guided peripheral vascular catheterization in pediatric patients: a narrative review2020

    • Author(s)
      Nakayama Y, Takeshita J, Nakajima Y, Shime N.
    • Journal Title

      Crit Care

      Volume: 24 Issue: 1 Pages: 592-592

    • DOI

      10.1186/s13054-020-03305-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-Axis In-Plane Approach Versus Short-Axis Out-of-Plane Approach for Ultrasound-Guided Central Venous Catheterization in Pediatric Patients: A Randomized Controlled Trial2020

    • Author(s)
      Jun Takeshita 1 2, Kazuya Tachibana 1, Yasufumi Nakajima 2, Gaku Nagai 1, Ai Fujiwara 1, Hirofumi Hamaba 1, Hideki Matsuura 1, Tomonori Yamashita 1, Nobuaki Shime 3
    • Journal Title

      Pediatr Crit Care Med .

      Volume: 11 Issue: 11 Pages: e996-e1001

    • DOI

      10.1097/pcc.0000000000002476

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bent peripheral venous catheter inserted using ultrasound-guided dynamic needle tip positioning.2020

    • Author(s)
      Takeshita J, Tachibana K, Nakajima Y, Shime N.
    • Journal Title

      J Vasc Access.

      Volume: Online ahead of print. Issue: 1 Pages: 154-156

    • DOI

      10.1177/1129729820983158

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ultrasonographic Detection of Micro-Bubbles in the Right Atrium to Confirm Peripheral Venous Catheter Position in Children.2019

    • Author(s)
      Takeshita J, Nakajima Y, Kawamura A, Taniguchi M, Shimizu Y, Takeuchi M, Shime N.
    • Journal Title

      Crit Care Med.

      Volume: 47(10) Issue: 10 Pages: e836-e840

    • DOI

      10.1097/ccm.0000000000003916

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Superiority of Dynamic Needle Tip Positioning for Ultrasound-Guided Peripheral Venous Catheterization in Patients Younger Than 2 Years Old: A Randomized Controlled Trial2019

    • Author(s)
      Takeshita J, Yoshida T, Nakajima Y, Nakayama Y, Nishiyama K, Ito Y, Shimizu Y, Takeuchi M, Shime N.
    • Journal Title

      Pediatr Crit Care Med.

      Volume: 20 (9) Issue: 9 Pages: e410-e414

    • DOI

      10.1097/pcc.0000000000002034

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dynamic Needle Tip Positioning for Ultrasound-Guided Arterial Catheterization in Infants and Small Children With Deep Arteries: A Randomized Controlled Trial.2018

    • Author(s)
      Takeshita J, Yoshida T, Nakajima Y, Nakayama Y, Nishiyama K, Ito Y, Shimizu Y, Takeuchi M, Shime N.
    • Journal Title

      J Cardiothorac Vasc Anesth.

      Volume: 印刷中 Issue: 7 Pages: 1-7

    • DOI

      10.1053/j.jvca.2018.12.002

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prohemostatic Activity of Factor X in Combination With Activated Factor VII in Dilutional Coagulopathy.2018

    • Author(s)
      Takeshita S, Ogawa S, Nakayama Y, Mukai N, Nakajima Y, Mizobe T, Sawa T, Tanaka KA.
    • Journal Title

      Anesth Analg.

      Volume: 印刷中 Issue: 2 Pages: 339-345

    • DOI

      10.1213/ane.0000000000003858

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Changes in MicroRNA Expression Level of Circulating Platelets Contribute to Platelet Defect After Cardiopulmonary Bypass.2018

    • Author(s)
      Mukai N, Nakayama Y, Ishi S, Ogawa S, Maeda S, Anada N, Murakami S, Mizobe T, Sawa T, Nakajima Y.
    • Journal Title

      Crit Care Med.

      Volume: 46 Issue: 8 Pages: e761-e767

    • DOI

      10.1097/ccm.0000000000003197

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Comparative Study of Point-of-Care Prothrombin Time in Cardiopulmonary Bypass Surgery2018

    • Author(s)
      Okabayashi S, Ogawa S, Tanaka KA, Nishiyama T, Takeshita S, Nakayama Y, Nakajima Y, Sawa T, Mizobe T.
    • Journal Title

      J Cardiothorac Vasc Anesth.

      Volume: In Press Issue: 4 Pages: 1609-1614

    • DOI

      10.1053/j.jvca.2017.12.044

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Potential contribution of erythrocyte microRNA to secondary erythrocytosis and thrombocytopenia in congenital heart disease2018

    • Author(s)
      Nobuhiro Mukai, Yoshinobu Nakayama, Satoshi, Murakami, Toshihito Tanahashi, Daniel Sessler, Sachiyo Ishii, Satoru Ogawa, Natsuko Tokuhira, Toshiki Mizobe, Teiji Sawa, , Yasufumi Nakajima
    • Journal Title

      Pediatric Research (e-pub ahead of print)

      Volume: - Issue: 4 Pages: 866-873

    • DOI

      10.1038/pr.2017.327

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in microRNA expression level of circulating platelets contribute to platelet dysfunction after cardiopulmonary bypass2018

    • Author(s)
      Mukai N, Nakayama Y, Nakajima Y, et al.
    • Journal Title

      Critical Care Medicine

      Volume: In Press

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of In-hospital Outcomes Between Transcatheter and Surgical Aortic Valve Replacement in Patients with Aortic Valve Stenosis: A Retrospective Cohort Study Using Administrative Data.2018

    • Author(s)
      Umegaki T, Kunisawa S, Nakajima Y, Kamibayashi T, Fushimi K, Imanaka Y.
    • Journal Title

      J Cardiothorac Vasc Anesth.

      Volume: In Press Issue: 3 Pages: 1281-1288

    • DOI

      10.1053/j.jvca.2017.06.047

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in platelet Bax levels contribute to impaired platelet response to thrombin after cardiopulmonary bypass: prospective observational clinical and laboratory investigations.2017

    • Author(s)
      Murase M, Nakayama Y, Sessler DI, Mukai N, Ogawa S, Nakajima Y.
    • Journal Title

      Br J Anaesth.

      Volume: 119(6) Issue: 6 Pages: 1118-1126

    • DOI

      10.1093/bja/aex349

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Flow-dynamics assessment of mitral-valve surgery by intraoperative vector flow mapping2017

    • Author(s)
      Akiyama K, Nakamura N, Itatani K, Naito Y, Kinoshita M, Shimizu M, Hamaoka S, Kato H, Yasumoto H, Nakajima Y, Mizobe T, Numata S, Yaku H, Sawa T.
    • Journal Title

      Int Cardiovasc Thorac Surg

      Volume: in press Issue: 6 Pages: 869-875

    • DOI

      10.1093/icvts/ivx033

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vector flow mapping analysis of left ventricular energetic performance in healthy adult volunteers2017

    • Author(s)
      Akiyama K, Maeda S, Matsuyama T, Kainuma A, Ishii M, Naito Y, Kinoshita M, Hamaoka S, Kato H, Nakajima Y, Nakamura N, Itatani K, Sawa T
    • Journal Title

      BMC Cardiovascular Disorders

      Volume: 17 Issue: 1 Pages: 21-21

    • DOI

      10.1186/s12872-016-0444-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ヒトの体温調節機構と、 麻酔・集中治療領域における 体温管理のコントラバーシー2019

    • Author(s)
      中嶋康文
    • Organizer
      日本臨床麻酔学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 3D-TEEの活用法2019

    • Author(s)
      中嶋康文
    • Organizer
      日本心臓血管麻酔学会
    • Related Report
      2019 Research-status Report
  • [Presentation] DES挿入患者の周術期の抗血栓療法抗凝固薬・抗血小板薬の周術期の使い方2017

    • Author(s)
      中嶋康文
    • Organizer
      日本麻酔科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 弁膜症ガイドライン Up To Date2017

    • Author(s)
      中嶋康文
    • Organizer
      日本心臓血管麻酔学会 JBPOT 講習会
    • Related Report
      2017 Research-status Report
  • [Presentation] 僧帽弁形成術とTEE2017

    • Author(s)
      中嶋康文
    • Organizer
      日本臨床麻酔学会
    • Related Report
      2017 Research-status Report
  • [Book] FAQでわかりやすい! 心臓麻酔臨床実践ガイド(第2版)2018

    • Author(s)
      秋山浩一,柴崎雅至, 中嶋康文 (澄川耕二 編)
    • Total Pages
      496
    • Publisher
      総合医学社
    • ISBN
      9784883786633
    • Related Report
      2017 Research-status Report
  • [Book] 検査値から考える周術期血液凝固異常(血小板異常症の項)2017

    • Author(s)
      中嶋康文 (香取信之  編)
    • Total Pages
      234
    • Publisher
      克誠堂
    • ISBN
      9784771904859
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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