| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Opioid receptors are expressed in breast cancer cells. It has been reported that morphine promotes tumor progression and metastasis. The mu-opioid receptor1 (OPRM1) A118G SNP is frequently discussed in terms of opioid analgesia and affinity with endogenous opioid. There are several research reports on the association between the G allele in the OPRM1 A118G SNP of the opioid receptor and the incidence of breast cancer.
To investigate the cause of discrepancy in research results, a three-group comparison with GG genotype as independent group has not yet been performed due to the low frequency of G allele in Caucasians. We performed a three-group comparison in Japanese women, who have a higher frequency of the mutant. No significant difference was deteted in the distribution of the OPRM1 A118G SNP in Japanese breast cancer patients by the three group comparison of AA/AG/GG genotypes. Further studies should be performed to determine the association between the SNPs and cancer incidence.
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