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Tumor targeting using boron neutron capture therapy

Research Project

Project/Area Number 17K11119
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionHirosaki University

Principal Investigator

Hatakeyama Shingo  弘前大学, 医学研究科, 准教授 (10400136)

Co-Investigator(Kenkyū-buntansha) 米山 徹  弘前大学, 医学研究科, 助教 (50587649)
石山 新太郎  弘前大学, 理工学研究科, 教授 (60355021)
飛澤 悠葵  弘前大学, 医学研究科, 助教 (70623768)
大山 力  弘前大学, 医学研究科, 教授 (80282135)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords中性子補足療法 / 糖鎖生物学 / がん化学療法 / 手術療法 / 癌特異的中性子補足療法 / ペプチド / がん特異的中性子治療 / 腫瘍血管内皮細胞 / 分子標的治療
Outline of Final Research Achievements

We developed a tumor-targeting Boron neutron capture therapy (BNCT) using tumor vasculature endothelium targeting peptide (IF7) conjugated boronophenylalanine (BPA-IF7) to improve the biodistribution of BPA. BPA or BPA-IF7 (7 mg/kg, 1/35 of effective dose) was intravenously administrated to MBT2 tumor-bearing mice. The tumors received reactor thermal neutron beam irradiation following the administration of 7 mg/kg of BPA-IF7. Tumor growth was compared between the irradiated (n=7) and control (n=19) mice for 2 weeks.Tumor concentration of B10 was 5-fold higher in the BPA-IF7 than that in the BPA. The tumor concentration of B10 reached 20 ppm within the 20 min in the BPA-IF7 mice. Tumor size was significantly decreased in the BPA-IF7 mice than that in the control mice. BPA-IF7 showed faster tumor-specific boron accumulation than conventional BPA and showed antitumor effects at low doses. BPA-IF7 has the potential to improve drug delivery of BPA and antitumor effect for BNCT.

Academic Significance and Societal Importance of the Research Achievements

現在の抗がん剤治療が抱える弱点は、細胞毒性の強い薬剤を全身投与する点にある。これら副作用を減らし高い抗腫瘍効果を得るためには高濃度の抗がん剤をがんのみに到達させる必要がある。我々の開発したB-IF7は、がん細胞に高濃度にホウ素を集積させることが出来るため、これら問題を解決できる可能性がある。さらに最近になって頭頚部癌に対する中性子補足療法が保険適応となったことを受け、中性子発生装置も広く普及していくものと思われ、我々の研究成果は学術的意義ならびに社会的意義の高い結果と思われる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (52 results)

All 2020 2019 2018 2017

All Journal Article (39 results) (of which Int'l Joint Research: 27 results,  Peer Reviewed: 39 results,  Open Access: 27 results) Presentation (13 results) (of which Int'l Joint Research: 9 results)

  • [Journal Article] Survey on attitudes toward brain-dead and living donor transplantation in medical students: a cross-sectional study in Japan.2020

    • Author(s)
      Hamano I, Hatakeyama S, Yamamoto H, Fujita T, Murakami R, Shimada M, Imai A, Yoneyama T, Yoneyama T, Hashimoto Y, Saitoh H, Suzuki T, Tomita H, Ohyama C
    • Journal Title

      Clin Exp Nephrol.

      Volume: - Issue: 7 Pages: 638-645

    • DOI

      10.1007/s10157-020-01878-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative chronic kidney disease predicts poor prognosis in patients with primary non?muscle-invasive bladder cancer who underwent transurethral resection of bladder tumor2020

    • Author(s)
      Fujita Naoki、Hatakeyama Shingo、Momota Masaki、Tobisawa Yuki、Yoneyama Tohru、Yamamoto Hayato、Imai Atsushi、Ito Hiroyuki、Yoneyama Takahiro、Hashimoto Yasuhiro、Yoshikawa Kazuaki、Ohyama Chikara
    • Journal Title

      Urologic Oncology: Seminars and Original Investigations

      Volume: - Issue: 8 Pages: 684.e1-684.e8

    • DOI

      10.1016/j.urolonc.2020.02.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between gut microbiome and erectile dysfunction: a community-based cross-sectional study in Japan.2020

    • Author(s)
      Okamoto T, Hatakeyama S, Imai A, Yamamoto H, Yoneyama T, Mori K, Yoneyama T, Hashimoto Y, Nakaji S, Ohyama C.
    • Journal Title

      Int Urol Nephrol.

      Volume: - Issue: 8 Pages: 1421-1428

    • DOI

      10.1007/s11255-020-02443-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unusual presentation of upper urinary tract urothelial carcinoma in Taiwan: Direct comparison from Taiwan‐Japan UTUC Collaboration Cohort2020

    • Author(s)
      Luo Hao Lun、Ohyama Chikara、Hatakeyama Shingo、Wang Hung Jen、Yoneyama Tohru、Yang Wen Chou、Chuang Yao Chi、Chen Yen Ta、Lee Wei Chin、Cheng Yuan Tso、Kang Chih Hsiung、Chiang Po Hui
    • Journal Title

      International Journal of Urology

      Volume: 27 Issue: 4 Pages: 327-332

    • DOI

      10.1111/iju.14188

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Avelumab plus axitinib vs sunitinib for advanced renal cell carcinoma: Japanese subgroup analysis from JAVELIN Renal 1012020

    • Author(s)
      Uemura Motohide、Tomita Yoshihiko、Miyake Hideaki、Hatakeyama Shingo、Kanayama Hiro‐omi、Numakura Kazuyuki、Takagi Toshio、Kato Tomoyuki、Eto Masatoshi、Obara Wataru、Uemura Hirotsugu、Choueiri Toni K.、Motzer Robert J.、Fujii Yosuke、Kamei Yoichi、Umeyama Yoshiko、Pietro Alessandra、Oya Mototsugu
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 3 Pages: 907-923

    • DOI

      10.1111/cas.14294

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Effect of Treatment Sequence on Overall Survival for Men With Metastatic Castration-resistant Prostate Cancer: A Multicenter Retrospective Study2020

    • Author(s)
      Okita Kazutaka、Hatakeyama Shingo、Narita Shintaro、Takahashi Masahiro、Sakurai Toshihiko、Kawamura Sadafumi、Hoshi Senji、Ishida Masanori、Kawaguchi Toshiaki、Ishidoya Shigeto、Shimoda Jiro、Sato Hiromi、Mitsuzuka Koji、Ito Akihiro、Tsuchiya Norihiko、Arai Yoichi、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: 18 Issue: 2 Pages: e103-e111

    • DOI

      10.1016/j.clgc.2019.09.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum N-glycan profiling is a potential biomarker for castration-resistant prostate cancer2019

    • Author(s)
      Matsumoto Teppei、Hatakeyama Shingo、Yoneyama Tohru、Tobisawa Yuki、Ishibashi Yusuke、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Ito Hiroyuki、Nishimura Shin-Ichiro、Ohyama Chikara
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 16761-16761

    • DOI

      10.1038/s41598-019-53384-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Characterization of Low Prostate-specific Antigen on Prognosis in Patients With Metastatic Castration-naive Prostate Cancer.2019

    • Author(s)
      Kodama H, Hatakeyama S, Narita S, Takahashi M, Sakurai T, Kawamura S, Hoshi S, Ishida M, Kawaguchi T, Ishidoya S, Shimoda J, Narita T, Sato H, Mitsuzuka K, Tochigi T, Tsuchiya N, Arai Y, Habuchi T, Ohyama C
    • Journal Title

      Clin Genitourin Cancer.

      Volume: 17(6) Issue: 6 Pages: e1091-e1098

    • DOI

      10.1016/j.clgc.2019.05.029

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in conditional net survival and dynamic prognostic factors in patients with newly diagnosed metastatic prostate cancer initially treated with androgen deprivation therapy.2019

    • Author(s)
      Narita S, Nomura K, Hatakeyama S, Takahashi M, Sakurai T, Kawamura S, Hoshi S, Ishida M, Kawaguchi T, Ishidoya S, Shimoda J, Sato H, Mitsuzuka K, Tochigi T, Tsuchiya N, Ohyama C, Arai Y, Nagashima K, Habuchi T
    • Journal Title

      Cancer Med.

      Volume: 8(15) Issue: 15 Pages: 6566-6577

    • DOI

      10.1002/cam4.2502

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of early changes in serum biomarker levels in patients with newly diagnosed metastatic prostate cancer.2019

    • Author(s)
      Narita S, Nomura K, Hatakeyama S, Takahashi M, Sakurai T, Kawamura S, Hoshi S, Ishida M, Kawaguchi T, Ishidoya S, Shimoda J, Sato H, Mitsuzuka K, Tochigi T, Tsuchiya N, Ohyama C, Arai Y, Nagashima K, Habuchi T
    • Journal Title

      Sci Rep.

      Volume: 9(1) Issue: 1 Pages: 12071-12071

    • DOI

      10.1038/s41598-019-48600-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of the IMDC Prognostic Model in Patients With Metastatic Renal-Cell Carcinoma Treated With First-Line Axitinib: A Multicenter Retrospective Study2019

    • Author(s)
      Konishi Sakae、Hatakeyama Shingo、Numakura Kazuyuki、Narita Shintaro、Inoue Takamitsu、Saito Mitsuru、Tokui Noriko、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Yoshikawa Kazuaki、Narita Satoshi、Kawaguchi Toshiaki、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: 17 Issue: 5 Pages: 1080-1089

    • DOI

      10.1016/j.clgc.2019.07.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C‐reactive protein/albumin ratio is a predictive factor for prognosis in patients with metastatic renal cell carcinoma2019

    • Author(s)
      Konishi Sakae、Hatakeyama Shingo、Tanaka Toshiaki、Ikehata Yoshinori、Tanaka Toshikazu、Hamano Itsuto、Fujita Naoki、Yoneyama Tohru、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Yoshikawa Kazuaki、Kawaguchi Toshiaki、Masumori Naoya、Kitamura Hiroshi、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 26 Issue: 10 Pages: 992-998

    • DOI

      10.1111/iju.14078

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of the LacdiNAc‐glycosylated Prostate‐Specific Antigen Assay for prostate cancer detection2019

    • Author(s)
      Yoneyama Tohru、Tobisawa Yuki、Kaneko Tomonori、Kaya Takatoshi、Hatakeyama Shingo、Mori Kazuyuki、Sutoh Yoneyama Mihoko、Okubo Teppei、Mitsuzuka Koji、Duivenvoorden Wilhelmina、Pinthus Jehonathan H.、Hashimoto Yasuhiro、Ito Akihiro、Koie Takuya、Suda Yoshihiko、Gardiner Robert A.、Ohyama Chikara
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 8 Pages: 2573-2589

    • DOI

      10.1111/cas.14082

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Disagreement Between Two Risk Group Models on Prognosis in Patients With Metastatic Renal-Cell Carcinoma2019

    • Author(s)
      Okita Kazutaka、Hatakeyama Shingo、Tanaka Toshiaki、Ikehata Yoshinori、Tanaka Toshikazu、Fujita Naoki、Ishibashi Yusuke、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Yoshikawa Kazuaki、Kawaguchi Toshiaki、Masumori Naoya、Kitamura Hiroshi、Ohyama Chikara
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: 印刷中 Issue: 3 Pages: e440-e446

    • DOI

      10.1016/j.clgc.2019.01.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of nutritional status on the prognosis of patients with metastatic hormone-na?ve prostate cancer: a multicenter retrospective cohort study in Japan2018

    • Author(s)
      Okamoto Teppei、Hatakeyama Shingo、Narita Shintaro、Takahashi Masahiro、Sakurai Toshihiko、Kawamura Sadafumi、Hoshi Senji、Ishida Masanori、Kawaguchi Toshiaki、Ishidoya Shigeto、Shimoda Jiro、Sato Hiromi、Mitsuzuka Koji、Tochigi Tatsuo、Tsuchiya Norihiko、Arai Yoichi、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      World Journal of Urology

      Volume: 99 Issue: 9 Pages: 000-0001

    • DOI

      10.1007/s00345-018-2590-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Postoperative weight loss followed by radical cystectomy predicts poor prognosis in patients with muscle-invasive bladder cancer2018

    • Author(s)
      Okita Kazutaka、Hatakeyama Shingo、Fujita Naoki、Konishi Sakae、Yamamoto Hayato、Imai Atsushi、Yoneyama Takahiro、Hashimoto Yasuhiro、Ito Hiroyuki、Yoshikawa Kazuaki、Koie Takuya、Ohyama Chikara
    • Journal Title

      Medical Oncology

      Volume: 36 Issue: 1 Pages: 7-7

    • DOI

      10.1007/s12032-018-1232-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of axitinib and sunitinib as first-line therapies for metastatic renal cell carcinoma: a real-world multicenter analysis2018

    • Author(s)
      Konishi Sakae、Hatakeyama Shingo、Tanaka Toshiaki、Ikehata Yoshinori、Tanaka Toshikazu、Fujita Naoki、Ishibashi Yusuke、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Yoshikawa Kazuaki、Kawaguchi Toshiaki、Masumori Naoya、Kitamura Hiroshi、Ohyama Chikara
    • Journal Title

      Medical Oncology

      Volume: 36 Issue: 1 Pages: 6-6

    • DOI

      10.1007/s12032-018-1231-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical impact of glomerular basement membrane thickness on post‐donation renal function in living donors2018

    • Author(s)
      Kubota Yuka、Hatakeyama Shingo、Narita Ikuyo、Shimada Michiko、Hashimoto Yasuhiro、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 26 Issue: 2 Pages: 309-311

    • DOI

      10.1111/iju.13850

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Condyloma Acuminata of the Urethra in a Male Renal Transplant Recipient: A Case Report2018

    • Author(s)
      Hamano I.、Hatakeyama S.、Yamamoto H.、Fujita T.、Murakami R.、Shimada M.、Imai A.、Yoneyama T.、Yoneyama T.、Hashimoto Y.、Koie T.、Narumi S.、Saitoh H.、Suzuki T.、Tomita H.、Ohyama C.
    • Journal Title

      Transplantation Proceedings

      Volume: 50 Issue: 8 Pages: 2553-2557

    • DOI

      10.1016/j.transproceed.2018.02.182

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neoadjuvant chemohormonal therapy followed by robot-assisted and minimum incision endoscopic radical prostatectomy in patients with high-risk prostate cancer: comparison of perioperative and oncological outcomes at single institution2018

    • Author(s)
      Fujita Naoki、Koie Takuya、Hashimoto Yasuhiro、Narita Takuma、Tobisawa Yuki、Tanaka Toshikazu、Noro Daisuke、Oikawa Masaaki、Hagiwara Kazuhisa、Yoneyama Tohru、Imai Atsushi、Yamamoto Hayato、Hatakeyama Shingo、Yoneyama Takahiro、Ohyama Chikara
    • Journal Title

      International Urology and Nephrology

      Volume: 50 Issue: 11 Pages: 1999-2005

    • DOI

      10.1007/s11255-018-1985-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between oxidative stress and lower urinary tract symptoms: results from a community health survey in Japan2018

    • Author(s)
      Matsumoto Teppei、Hatakeyama Shingo、Imai Atsushi、Tanaka Toshikazu、Hagiwara Kazuhisa、Konishi Sakae、Okita Kazutaka、Yamamoto Hayato、Tobisawa Yuki、Yoneyama Tohru、Yoneyama Takahiro、Hashimoto Yasuhiro、Koie Takuya、Nakaji Shigeyuki、Ohyama Chikara
    • Journal Title

      BJU International

      Volume: 123 Issue: 5 Pages: 877-884

    • DOI

      10.1111/bju.14535

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Robotic cross-folded U-configuration intracorporeal ileal neobladder for muscle-invasive bladder cancer: Initial experience and functional outcomes2018

    • Author(s)
      Koie Takuya、Ohyama Chikara、Yoneyama Takahiro、Nagasaka Hirotaka、Yamamoto Hayato、Imai Atsushi、Hatakeyama Shingo、Hashimoto Yasuhiro
    • Journal Title

      The International Journal of Medical Robotics and Computer Assisted Surgery

      Volume: 14 Issue: 6 Pages: e1955-e1955

    • DOI

      10.1002/rcs.1955

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low serum butyrylcholinesterase is independently related to low fetuin-A in patients on hemodialysis: a cross-sectional study2018

    • Author(s)
      Okamoto Teppei、Tsutaya Chikako、Hatakeyama Shingo、Konishi Sakae、Okita Kazutaka、Tanaka Yoshimi、Imanishi Kengo、Takashima Tooru、Saitoh Fumitada、Suzuki Tadashi、Ohyama Chikara
    • Journal Title

      International Urology and Nephrology

      Volume: 50 Issue: 9 Pages: 1713-1720

    • DOI

      10.1007/s11255-018-1957-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proton pump inhibitor as an independent factor of progression of abdominal aortic calcification in patients on maintenance hemodialysis2018

    • Author(s)
      Okamoto Teppei、Hatakeyama Shingo、Hosogoe Shogo、Tanaka Yoshimi、Imanishi Kengo、Takashima Toru、Saitoh Fumitada、Suzuki Tadashi、Ohyama Chikara
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: 199160-199160

    • DOI

      10.1371/journal.pone.0199160

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differences in semen characteristics between patients with testicular cancer and other malignancies using various cut-off values2018

    • Author(s)
      Hamano Itsuto、Hatakeyama Shingo、Nakamura Rika、Fukuhara Rie、Noro Daisuke、Tanaka Toshikazu、Yoneyama Tohru、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Koie Takuya、Yokoyama Yoshihito、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 25 Issue: 9 Pages: 817-824

    • DOI

      10.1111/iju.13732

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Risk-stratified surveillance protocol improves cost-effectiveness after radical nephroureterectomy in patients with upper tract urothelial carcinoma2018

    • Author(s)
      Momota Masaki、Hatakeyama Shingo、Yamamoto Hayato、Iwamura Hiromichi、Tobisawa Yuki、Yoneyama Tohru、Yoneyama Takahiro、Hashimoto Yasuhiro、Koie Takuya、Iwabuchi Ikuya、Ogasawara Masaru、Kawaguchi Toshiaki、Ohyama Chikara
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 33 Pages: 23047-23057

    • DOI

      10.18632/oncotarget.25198

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Asymptomatic recurrence detection and cost-effectiveness in urothelial carcinoma2018

    • Author(s)
      Iwamura Hiromichi、Hatakeyama Shingo、Sato Makoto、Ohyama Chikara
    • Journal Title

      Medical Oncology

      Volume: 35 Issue: 6 Pages: 94-94

    • DOI

      10.1007/s12032-018-1152-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sleep Disturbance Has a Higher Impact on General and Mental Quality of Life Reduction than Nocturia: Results from the Community Health Survey in Japan2018

    • Author(s)
      Kido Koichi、Hatakeyama Shingo、Imai Atsushi、Yamamoto Hayato、Tobisawa Yuki、Yoneyama Tohru、Yoneyama Takahiro、Hashimoto Yasuhiro、Koie Takuya、Nakaji Shigeyuki、Ohyama Chikara
    • Journal Title

      European Urology Focus

      Volume: 99 Issue: 6 Pages: 0001-0001

    • DOI

      10.1016/j.euf.2018.04.017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical implication of a quantitative frailty assessment tool for prognosis in patients with urological cancers2018

    • Author(s)
      Soma Osamu、Hatakeyama Shingo、Okamoto Teppei、Fujita Naoki、Matsumoto Teppei、Tobisawa Yuki、Yoneyama Tohru、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Koie Takuya、Nakaji Shigeyuki、Ohyama Chikara
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 25 Pages: 0001-0001

    • DOI

      10.18632/oncotarget.24712

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Partial Cystectomy of Paraganglioma of the Urinary Bladder Before Living Kidney Transplantation: Case Report2018

    • Author(s)
      Kido K.、Hatakeyama S.、Hamano I.、Yamamoto H.、Imai A.、Yoneyama T.、Hashimoto Y.、Koie T.、Fujita T.、Murakami R.、Tomita H.、Suzuki T.、Narumi S.、Ohyama C.
    • Journal Title

      Transplantation Proceedings

      Volume: 50 Issue: 3 Pages: 898-901

    • DOI

      10.1016/j.transproceed.2018.01.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Butyrylcholinesterase level as an independent factor of erythropoiesis-stimulating agent resistance in patients on maintenance hemodialysis: a single-center cross-sectional study2018

    • Author(s)
      Okamoto Teppei、Hatakeyama Shingo、Tanaka Yoshimi、Imanishi Kengo、Takashima Tooru、Saitoh Fumitada、Koie Takuya、Suzuki Tadashi、Ohyama Chikara
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 22 Issue: 5 Pages: 1174-1181

    • DOI

      10.1007/s10157-018-1569-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Case of Fibrous Pseudotumor in the Scrotum: Challenge for Diagnosis and Testicular Preservation2018

    • Author(s)
      Kodama Hirotake、Hatakeyama Shingo、Matsumoto Teppei、Tanaka Toshikazu、Horiguchi Hirotaka、Kubota Yuka、Yamamoto Hayato、Imai Atsushi、Yoneyama Takahiro、Hashimoto Yasuhiro、Koie Takuya、Ohyama Chikara
    • Journal Title

      Case Reports in Urology

      Volume: 2018 Pages: 1-4

    • DOI

      10.1155/2018/6904827

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The relationship between poor nutritional status and progression of aortic calcification in patients on maintenance hemodialysis2018

    • Author(s)
      Okamoto Teppei、Hatakeyama Shingo、Kodama Hirotake、Horiguchi Hirotaka、Kubota Yuka、Kido Koichi、Momota Masaki、Hosogoe Shogo、Tanaka Yoshimi、Takashima Tooru、Saitoh Fumitada、Suzuki Tadashi、Ohyama Chikara
    • Journal Title

      BMC Nephrology

      Volume: 19 Issue: 1 Pages: 0001-0001

    • DOI

      10.1186/s12882-018-0872-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Impact of Preoperative Severe Renal Insufficiency on Poor Postsurgical Oncological Prognosis in Patients with Urothelial Carcinoma.2018

    • Author(s)
      Momota M, Hatakeyama S, Tokui N, Sato T, Yamamoto H, Tobisawa Y, Yoneyama T, Yoneyama T, Hashimoto Y, Koie T, Narita S, Kawaguchi T, Ohyama C
    • Journal Title

      Eur Urol Focus.

      Volume: 掲載確定・印刷中 Issue: 6 Pages: 001-001

    • DOI

      10.1016/j.euf.2018.03.003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detecting asymptomatic recurrence after radical nephroureterectomy contributes to better prognosis in patients with upper urinary tract urothelial carcinoma.2018

    • Author(s)
      Horiguchi H, Hatakeyama S, Anan G, Kubota Y, Kodama H, Momota M, Kido K, Yamamoto H, Tobisawa Y, Yoneyama T, Yoneyama T, Hashimoto Y, Koie T, Ito H, Yoshikawa K, Kawaguchi T, Sato M, Ohyama C
    • Journal Title

      Oncotarget.

      Volume: 9 Issue: 9 Pages: 8746-8755

    • DOI

      10.18632/oncotarget.23982

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of bacillus Calmette-Guerin therapy of upper urinary tract carcinoma in situ: comparison of oncological outcomes with radical nephroureterectomy.2018

    • Author(s)
      Horiguchi H, Yoneyama T, Hatakeyama S, Tokui N, Sato T, Fujita N, Yamamoto H, Tobisawa Y, Yoneyama T, Hashimoto Y, Koie T, Yoshikawa K, Narita S, Kawaguchi T, Ohyama C
    • Journal Title

      Med Oncol.

      Volume: 35 Issue: 4 Pages: 41-41

    • DOI

      10.1007/s12032-018-1102-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oncologic outcomes for open and laparoscopic radical nephroureterectomy in patients with upper tract urothelial carcinoma.2018

    • Author(s)
      Kido K, Hatakeyama S, Fujita N, Yamamoto H, Tobisawa Y, Yoneyama T, Yoneyama T, Hashimoto Y, Koie T, Iwabuchi I, Ogasawara M, Kawaguchi T, Ohyama C
    • Journal Title

      Int J Clin Oncol.

      Volume: 掲載確定・印刷中 Issue: 4 Pages: 726-733

    • DOI

      10.1007/s10147-018-1248-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report2018

    • Author(s)
      Hamano Itsuto、Hatakeyama Shingo、Nakamura Rika、Fukuhara Rie、Noro Daisuke、Seino Hiroko、Yoneyama Takahiro、Hashimoto Yasuhiro、Koie Takuya、Yokoyama Yoshihito、Ohyama Chikara
    • Journal Title

      Basic and Clinical Andrology

      Volume: 28 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s12610-018-0066-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Slow Progression of Aortic Calcification Is a Potential Benefit of Pre-emptive Kidney Transplantation.2017

    • Author(s)
      Mursawa H, Hatakeyama S, Yamamoto H, Tanaka Y, Soma O, Matsumoto T, Yoneyama T, Hashimoto Y, Koie T, Fujita T, Murakami R, Saitoh H, Suzuki T, Narumi S, Ohyama C
    • Journal Title

      Transplant Proc.

      Volume: 50 Issue: 1 Pages: 145-149

    • DOI

      10.1016/j.transproceed.2017.12.011

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] What is benefit of robot assisted radical cystectomy(RARC)? The comparison of open radical prostatectomy (ORC) with RARC?2019

    • Author(s)
      Hatakeyama S, Yamamoto H, Imai A, Yoneyama T, Hashimoto Y, Koie T, Ohyama C
    • Organizer
      2nd ASIA Urological Oncology Forum 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Axitinib vs Sunitinib as first-line therapies for metastatic renal cell carcinoma: A multicenter retrospective analysis2019

    • Author(s)
      Hatakeyama S, Konishi S, Tanaka T, Ikehata Y, Fujita N, Ishibashi Y, Masumori N, Kitamura H, Yamamoto H, Imai A, Yoneyama T, Hashimoto Y, Ohyama C
    • Organizer
      米国泌尿器腫瘍学会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of disagreement between the IMDC and MSKCC risk groups on prognosis in patients with metastatic renal cell carcinoma2019

    • Author(s)
      Hatakeyama S, Okita K, Tanaka T, Ikehata Y, Fujita N, Ishibashi Y, Masumori N, Kitamura H, Yamamoto H, Imai A, Yoneyama T, Hashimoto Y, Ohyama C
    • Organizer
      米国泌尿器腫瘍学会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The impact of fall on nocturia and frailty in community-dwelling individuals.2019

    • Author(s)
      Hatakeyama S, Konishi S, Yamamoto H, Imai A, Yoneyama T1 Hashimoto Y, Nakaji S, Ohyama C
    • Organizer
      欧州泌尿器科学会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ロボット支援下 根治的膀胱全摘除術(RARC)は低侵襲か?開腹下根治的膀胱全摘術(ORC)との比較.2019

    • Author(s)
      畠山真吾,山本勇人,今井 篤,米山高弘,橋本安弘,古家琢也,大山 力:
    • Organizer
      第 11 回日本ロボット外科学会学術集会 2019 年 1 月 26 日 名古屋市(名古屋コンベンションホー ル)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 血清糖鎖プロファイリング による去勢抵抗前立腺癌のバイオマーカー探索.2019

    • Author(s)
      畠山真吾,米山 徹,山本勇人,米山高弘,橋本安弘,大山 力
    • Organizer
      28 回泌尿器科分子・細胞研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Clinical impact of glomerular basement membrane thickness on donor renal function after kidney donation2018

    • Author(s)
      Hatakeyama S, Yoneyama T, Kodama H, Kusaka A, Hosogoe S, Tokui N, Yamamoto H, Yoneyama T, Hashimoto Y, Koie T, Ohyma C
    • Organizer
      米国泌尿器科会議)2018年5月18-21日 サンフランシスコ
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diagnostic potential of aberrant N-Glycosylation of serum immunoglobulins in patients with urothelial carcinoma2018

    • Author(s)
      Hatakeyama S, Yoneyama T, Ohyama C
    • Organizer
      URS 2018 IN KOREA 2018.10.1-2.  韓国ソウル
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The relationship between preoperative stage 3B chronic kidney disease and post-surgical oncological outcomes in patients with urothelial carcinoma2018

    • Author(s)
      Hatakeyama S, Yamamoto H, Imai A, Yoneyama T, Hashimoto Y, Koie T, Ohyama C
    • Organizer
      ESMO ASIA 2018年11月22-25日 シンガポール
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Does neoadjuvant chemotherapy promote chemoresistance after recurrence in patients with muscle-invasive bladder cancer?2018

    • Author(s)
      Hatakeyama S, Kodama H, Konishi S, Okita K, Yamamoto H, Imai A, Yoneyama T, Hashimoto Y, Koie T, Ohyama C
    • Organizer
      ESMO ASIA 2018年11月22-25日 シンガポール
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The gap of frailty value from a community-dwelling population predict oncological outcomes in patients with urological cancers.2018

    • Author(s)
      Hatakeyama S, Konishi S, Okita K, Soma O, Matsumoto T, Yoneyama T, Hashimoto Y, Koie T, Ohyama C
    • Organizer
      ESMO ASIA 2018年11月22-25日 シンガポール
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impact of frailty on treatment modality selection in patients with muscle-invasive bladder cancer: Radical cystectomy vs bladder preservation therapy2018

    • Author(s)
      Hatakeyama S, Soma O, Yamamoto H, Imai A, Yoneyama T, Hashimoto Y, Ohyama C
    • Organizer
      EAU 2019 第34回欧州泌尿器学会議 2019年3月15-19日 スペイン(バルセロナ)
    • Related Report
      2018 Research-status Report
  • [Presentation] Development and validation of the prediction nomogram for a stone episode2018

    • Author(s)
      Hatakeyama S, Imai A, Hamano I, Tanaka T, Yoneyama T, Yamamoto H, Yoneyama T, Hashimoto Y, Nakaji S, Ohyama C
    • Organizer
      EAU 2019 第34回欧州泌尿器学会議 2019年3月15-19日 スペイン(バルセロナ)
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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