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Genome analysis during recurrence of urothelial cancer

Research Project

Project/Area Number 17K11136
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionKobe University

Principal Investigator

Hinata Nobuyuki  神戸大学, 医学研究科, 特命准教授 (10598816)

Co-Investigator(Kenkyū-buntansha) 岡村 泰義  神戸大学, 医学部附属病院, 医員 (90806100)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords尿路上皮癌 / 管腔内再発 / エクソーム解析 / 再発予防 / 再発 / 全エクソーム解析 / 癌 / ゲノム / 外科
Outline of Final Research Achievements

All exome analysis was performed on 4 cases, 4 samples at the first onset, and 5 samples at the time of recurrence (including 1 case relapse). The average depth of the specimen was 117 and 12046 SNVs were identified on average. The common SNVs in the first and recurrent cases were 10683 on average in 4 cases, and it is considered that they have the same origin from the phylogenetic tree analysis, but this analysis alone cannot conclude either seeding or multicentric development It was Many gene mutations reported in The Cancer Genome Atlas were also found. FAM8A1, HLA-DRB1, HLA-DRB5, HRNR, NBPF1, NBPF10, NBPF20, and PABPC3 were found as common mutated genes in recurrent cases.

Academic Significance and Societal Importance of the Research Achievements

本解析のみでは再発の起源が播種か多中心性発生かを結論づけることはできなかったが、再発症例に共通してみられる変異遺伝子としてFAM8A1、HLA-DRB1、HLA-DRB5、HRNR、NBPF1、NBPF10、NBPF20、PABPC3を同定した。今後は引き続き症例を増やしての検討を行うとともに、同定された変異遺伝子再発に及ぼす機序の解明により、新規治療ターゲットとなるゲノム変異を特定する。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2020 2019

All Journal Article (1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] Switching of Sox9 Expression During Musculoskeletal System Development2020

    • Author(s)
      Ryotaro Nagakura, Masahito Yamamoto, Juhee Jeong , Nobuyuki Hinata , Yukio Katori , Wei-Jen Chang , Shinichi Abe
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 8425-8425

    • DOI

      10.1038/s41598-020-65339-9

    • Related Report
      2019 Annual Research Report
  • [Presentation] 当院におけるアミノレブリン酸塩酸塩を併用した経尿道的膀胱腫瘍切除術の臨床検討2019

    • Author(s)
      大西 篤史, 寺川 智章, 千葉 公嗣, 古川 順也, 原田 健一, 重村 克巳, 日向 信之, 藤澤 正人
    • Organizer
      日本内視鏡外科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 泌尿器科癌骨転移に対する治療2019

    • Author(s)
      日向信之
    • Organizer
      日本泌尿器科学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 当施設におけるロボット支援根治的膀胱全摘除術の経験2019

    • Author(s)
      日向信之、古川順也、原田健一、石村武志、中野雄造、藤澤正人
    • Organizer
      日本泌尿器科学会総会
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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