Establishment of a new gene therapy strategy for prostate cancer stem cells
| Project/Area Number |
17K11138
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
HUANG PENG 岡山大学, 医歯薬学総合研究科, 研究准教授 (00610841)
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| Co-Investigator(Kenkyū-buntansha) |
那須 保友 岡山大学, 医歯薬学総合研究科, 教授 (20237572)
定平 卓也 岡山大学, 大学病院, 助教 (20733322)
植木 英雄 岡山大学, 医学部, 技術専門職員 (90537218)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 前立腺がん / 癌幹細胞 / 遺伝子治療 / 前立腺癌 / REIC/DKK-3 / ips細胞 / iPS細胞 / 標的治療 |
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| Outline of Final Research Achievements |
In this study, using an independently developed REIC gene vector and prostate cancer cancer stem cells, we clarified what kind of intracellular signal during autophagy induction is involved in the construction of the stationary phase maintenance of cancer stem cells, and elucidated the molecular basis for targeting cancer stem cells. The results of this study are to strengthen the foundation for the creation of cancer stem cell-targeted therapies based on REIC / Dkk-3 gene seeds in Japan, and to correspond to endoplasmic reticulum stress responses not only to urological cancer but also to many refractory solid tumors. We determined that this would be the basis for the development of a new autophagy-induced gene therapy.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の申請研究による成果は、REIC/Dkk-3遺伝子を基盤シーズとする日本発の癌幹細胞標的治療の創出基盤を強化し、泌尿器科領域の癌のみならず、多くの難治固形癌に対する、小胞体ストレス応答より新規オートファジー誘導遺伝子治療の展開基盤になるものと判断された。
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] The Novel Combination of Nitroxoline and PD-1 Blockade, Exerts a Potent Antitumor Effect in a Mouse Model of Prostate Cancer2019
Author(s)
Naijin Xu, Linglong Huang, Xiezhao Li, Masami Watanabe, Chaoming Li, Abai Xu, Chunxiao Liu, Qiang Li, Motoo Araki, Koichiro Wada, Yasutomo Nasu, Peng Huang
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Journal Title
International Journal of Biological Sciences
Volume: 15
Issue: 5
Pages: 919-928
DOI
Related Report
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[Journal Article] Induction of cells with prostate cancer stem-like properties from mouse induced pluripotent stem cells via conditioned medium2018
Author(s)
Xu N, Li X, Watanabe M, Ueki H, Hu H, Li N, Araki M, Wada K, Xu A, Liu C, Nasu Y, Huang P
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Journal Title
Am J Cancer Res
Volume: 8
Pages: 1624-1632
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] A novel nitroxoline treatment, targeting the PI3K pathway, in combination with PD-1 blockage, exerts a potent prostate cancer anti-tumor effect2018
Author(s)
Naijin Xu , Chaoming Li , Abai Xu , Chunxiao Liu , Qiang Li , Masami Watanabe , Motoo Araki , Koichiro Wada Yasutomo Nasu, Peng Huang
Organizer
AUA2018
Related Report
Int'l Joint Research
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