Establishment of the novel treatment strategy against urothelial carcinoma controlling for cancer stem-like property
| Project/Area Number |
17K11157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | St. Marianna University School of Medicine (2019)
Keio University (2017-2018) |
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Principal Investigator |
Kikuchi Eiji 聖マリアンナ医科大学, 医学部, 教授 (10286552)
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| Co-Investigator(Kenkyū-buntansha) |
小坂 威雄 慶應義塾大学, 医学部(信濃町), 講師 (30445407)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 尿路上皮癌 / 癌幹細胞 / 抗癌剤耐性 / シスプラチン / 膀胱癌 / 治療戦略 |
|---|
| Outline of Final Research Achievements |
The following five results were obtained. (1) High expression of CD44v9 in tumor specimen is a prognostic factor in patients with muscle invasive bladder cancer. (2) CD44v8-10 is highly associated with acquisition of resistance for anti-cancer agents in bladder cancer. (3) In current smoker bladder cancer patients high PD-1 expression in tumor nest is a prognostic factor (4) Metformin had cytotoxic effects against T24 cell line with high CD44v expression. (5) In mouse bladder cancer lung metastatic model, sulfasalazine plus cisplatin had strong anti-tumor effects.
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| Academic Significance and Societal Importance of the Research Achievements |
尿路上皮癌におけるCD44v9、喫煙膀胱癌におけるPD-1は今後予後マーカーとしての確立が望まれる。このことにより予後不良症例の抽出、リスク分類が可能となり個別化治療への応用の意義が示唆される。CD44vは膀胱癌の抗癌剤耐性獲得に寄与し、CD44vをターゲットしたメトホルミンやサラゾスルファピリジンは次世代の新規治療戦略として期待されると考える。
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Report
(4 results)
Research Products
(4 results)
