Development of non-coding RNA-targeting therapy for refractory renal carcinoma
| Project/Area Number |
17K11166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
Kawamura Sadafumi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (40292213)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 賢一 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (10282055)
玉井 恵一 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (40509262)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | non coding RNA / ncRNA / 腎癌 / PDX / 腎細胞癌 |
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| Outline of Final Research Achievements |
Renal carcinoma is the third most common malignancy following prostate and bladder cancer, while the mortality is the highest (40%) among them. We identified non coding RNA HOTAIR which is involved in the malignant characteristics. We further identified a novel non-coding RNA which is also promote cancer malignancy.
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| Academic Significance and Societal Importance of the Research Achievements |
私たちはnon-coding RNAに着目して、癌の悪性度を亢進させる新たなnon-coding RNAを同定した。詳細な分子機構の解析を行うことで、将来的に治療標的となる可能性がある。
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Report
(5 results)
Research Products
(2 results)
