Effects of prenatal exposure to endocrine disruption chemicals on gonadal function and sexual dimorphism
| Project/Area Number |
17K11171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Moriya Kimihiko 北海道大学, 医学研究院, 客員研究員 (20374233)
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| Co-Investigator(Kenkyū-buntansha) |
中村 美智子 北海道大学, 大学病院, 助教 (60571718)
篠原 信雄 北海道大学, 医学研究院, 教授 (90250422)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 性分化 / 内分泌かく乱物質 / 胎児期曝露 / 遺伝子多型 / ESR1遺伝子 / 内分泌かく乱化学物質 / エストロゲン受容体 / 一塩基多型 / 第2指と第4指の比 / 環境化学物質 / 排泄の確立 / 性分化・環境化学物質 / 胎児期 / 性腺機能 |
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| Outline of Final Research Achievements |
It has been reported that some endocrine disrupting chemicals has estrogenic effect. In the present study, effect of prenatal exposure of the endocrine disrupting chemicals on sexual differentiation and its modification by single nucleotide polymorphism of estrogen receptor gene (ESR1-SNP) were examined. Digit ratio of 2nd and 4th finger (2D:4D) was utilizes as a maker of sex differentiation in the present study because it has been reported to be affected by prenatal exposure of sex hormones. First, impact of ESR1-SNP on 2D:4D was evaluated. Then, effect of phthalate esters and Bisphenol A, which were demonstrated to have estrogenic effect in previous studies, and ESR1-SNP on 2D:4D was estimated.
As results, rs9340799, one of the ESR1-SNP, affected 2D:4D. Phthalate esters affected 2D:4D in boys with G allele of rs2077647, one of the ESR1-SNP.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の検討から、エストロゲン様作用を有するとされるEDCsへの胎児期曝露が性分化へ与える影響は単に曝露量のみではなくESR1遺伝子SNPの影響を受けていることが示唆された。本研究の結果はEDCsの胎児期曝露の影響が出やすいSNPを有する群が存在する可能性を示している。現在、環境化学物質曝露と停留精巣や尿道下裂などの小児泌尿器科疾患との関連が注目されている。本研究は、胎児期EDCs曝露による性分化への影響を受ける可能性の高い母児の抽出に役立つのみならず、彼らに対する曝露低減や生活習慣指導など、今後の予防対策・環境政策に寄与する可能性があると考えられた。
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Effects of prenatal sex hormones on behavioral sexual dimorphism.2019
Author(s)
Mitsui T, Araki A, Miyashita C, Ito S, Ikeno T, Sasaki S, Kitta T, Moriya K, Cho K, Morioka K, Kishi R, Shinohara N, Takeda M, Nonomura K.
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Journal Title
Pediatr Int.
Volume: 61
Issue: 2
Pages: 140-146
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between ESR1 polymorphisms and second to fourth digit ratio in school-aged children in the Hokkaido Study.2019
Author(s)
Nishimura Y, Moriya K, Kobayashi S, Araki A, Sata F, Mitsui T, Itoh S, Miyashita C, Cho K, Kon M, Nakamura M, Kitta T, Murai S, Kishi R, Shinohara N.
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Journal Title
Steroids
Volume: 141
Pages: 55-62
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study.2018
Author(s)
Miyashita C, Araki A, Mitsui T, Itoh S, Goudarzi H, Sasaki S, Kajiwara J, Hori T, Cho K, Moriya K, Shinohara N, Nonomura K, Kishi R.
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Journal Title
Environ Int
Volume: 117
Pages: 175-185
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-term Outcome of Adenosine A2A Receptor Antagonist on Lower Urinary Tract Symptoms in Male Parkinson Disease Patients.2018
Author(s)
Kitta T, Yabe I, Kanno Y, Higuchi M, Ouchi M, Togo M, Moriya K, Takahashi I, Matsushima M, Sasaki H, Shinohara N.
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Journal Title
Clin Neuropharmacol
Volume: 41
Issue: 3
Pages: 98-102
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates: The Hokkaido Study on Environment and Children's Health.2017
Author(s)
Minatoya M, Sasaki S, Araki A, Miyashita C, Itoh S, Yamamoto J, Matsumura T, Mitsui T, Moriya K, Cho K, Morioka K, Minakami H, Shinohara N, Kishi R.
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Journal Title
Epidemiology.
Volume: -
Pages: S3-S9
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Bladder Control and Behavioral Sexual Dimorphism in Children2019
Author(s)
Kimihiko Moriya, Yoko Nishimura, Michiko Nakamura, Masafumi Kon, Takeya Kitta, Atsuko Araki, Chihiro Miyashita, Sachiko Ito, Kazutoshi Cho, Takahiko Mitsui, Sachiyo Murai, Katsuya Nonomura, Reiko Kishi, Nobuo Shinohara
Organizer
2019 AUA/SPU meeting
Related Report
Int'l Joint Research
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