| Project/Area Number |
17K11196
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
飯野 賢治 金沢大学, 附属病院, 講師 (60595453)
加藤 寛城 金沢大学, 附属病院, 助教 (20733843)
|
|---|
| Project Period (FY) |
2017-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 移植腎保存 / 微弱磁場環境下冷却装置 / Cells Alive System / 移植・再生医療 / 腎移植 / 臓器保護 |
|---|
| Outline of Final Research Achievements |
In the present study, we evaluated the effectiveness of hypothermic preservation of porcine kidney graft in a variable magnetic field. Unilateral nephrectomy was done under general anesthesia. After perfusion at 250 ml of 4°C UW solution, the grafts were subjected to either 4°C in a variable magnetic field, 0°C in a variable magnetic field, or simple 4°C storage.
Reperfusion was performed after 24 hours of storage and we evaluated the function of the preserved kidneys, but no statistically significant difference was obtained.
|
| Academic Significance and Societal Importance of the Research Achievements |
今回の研究では正常腎ドナーモデルにおいてもマージナルドナーモデル（温阻血障害モデル）においても３群間（保存方法の違い）による有意差は認められなかった。
その理由としては、温阻血時間が短かった、保存時間が24時間と長時間であった、微弱磁場が腎深部まで及ばなかった、などが考えられる。今後の課題として、それら条件を再考する必要があると思われた。
|
