Analysis of male infertility and peroxisome dysfunction
| Project/Area Number |
17K11208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
Mizuno Yumi 埼玉医科大学, 医学部, 講師 (20584014)
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| Co-Investigator(Kenkyū-buntansha) |
水野 洋介 埼玉医科大学, 医学部, 准教授 (30406532)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 不妊症 / 男性不妊症 / ペルオキシソーム / 奇形精子 / Tysnd1 / 不妊 / 精子形成 / セルトリ細胞 / 男性不妊 / 雄性不妊 / ミトコンドリア / 造精機能障害 / 脂質代謝 |
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| Outline of Final Research Achievements |
We have revealed that abnormalities in the plasmalogen synthesis process result in malformed sperm. In this study, we show that oral administration of plasmalogen precursors helps improve acrosome formation in malformed sperm. Tysnd1 KO mice that have abnormal peroxisomal lipid metabolism, abnormalities occur in the formation of acrosome membranes or adhesion between membranes in sperms. In addition, we found that the cytoplasm remain partly during the morphology changes of sperm. Next, in the analysis of human sperm, we were able to discover a molecule that can be a marker for male infertility.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、これまで詳細のわかっていなかった、精子形成におけるペルオキシソームの役割について明らかにすることができた。また、男性不妊症のマーカーになりうる分子を見つけることができた。少子高齢化が進む日本では、不妊症の治療に関わる知見は重要であり、本研究での奇形精子の発症メカニズムに関する成果は、将来の不妊症の治療や男性不妊症の検査マーカーとして役立てられる可能性がある。
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Report
(5 results)
Research Products
(15 results)
