| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, we confirmed that PKX deficiency resulted in activation of AKT in differentiated trophoblast stem cells (day6-TSC). AKT is known to be comprised three highly homologous isoforms: AKT1, AKT2, and AKT3. All three AKT isoforms were expressed in day6-TSC with almost equivalent levels between wild-type and PKX-null genotypes. However, upregulation of phosphorylation was observed in all three AKT isoforms derived from PKX-null cells compared with wild-type cells. Because PKX deficiency did not influence expression and the activity of the factors which have been already known as a regulation factor of AKT, it was suggested that PKX regulate AKT phosphorylation through unknown mechanism.
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