Elucidation of the molecular mechanism of endometriosis focusing on epithelial cells.
| Project/Area Number |
17K11218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HIRATA TETSUYA 東京大学, 医学部附属病院, 登録研究員 (30431860)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 子宮内膜症 / 月経困難症 / GWAS / PAX8 / IFITM1 / ALDH1A / 子宮内膜症上皮 / 子宮内膜症上皮細胞 / 生殖医学 |
|---|
| Outline of Final Research Achievements |
To elucidate the pathogenesis of endometriosis, it is essential to focus on the epithelial cells of endometriosis. We focused on the properties of endometriotic epithelial cells. In addition, we focused on epithelial cells of extragenital endometriosis, and found that PAX8 is a highly sensitive endometriotic epithelial marker. We also demonstrated that IFITM1 can be used as a novel endometriosis stromal cell marker. In addition, a genome-wide association analysis of dysmenorrhea revealed an association with LOCUS associated with NGF, IL1A, and IL1B. Further studies will be conducted based on these results.
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| Academic Significance and Societal Importance of the Research Achievements |
子宮内膜症に対する新規病理診断マーカーを見出した。これにより、診断が難しい稀少部位子宮内膜症の病理診断がより正確になり、術後にホルモン療法が必要な患者を正確に抽出し、子宮内膜症の増悪や再発の抑制につながると考える。また、月経困難症とNGFやIL1の関連を見出したことで、早期診断法や新規治療法の開発につながると考える。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Expression of ALDH1A Isozymes in Human Endometrium With and Without Endometriosis and in Ovarian Endometrioma2020
Author(s)
Ma Suke, Hirata Tetsuya, Tomoko Arakawa, Sun Hui, Neriishi Kazuaki, Fukuda Shinya, Nakazawa Akari, Wang Yu, Harada Miyuki, Hirota Yasushi, Koga Kaori, Wada-Hiraike Osamu, Fujii Tomoyuki, Osuga Yutaka
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Journal Title
Reproductive Sciences
Volume: 27
Pages: 443-452
Related Report
Peer Reviewed
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[Journal Article] A National Survey of Umbilical Endometriosis in Japan2020
Author(s)
Hirata Tetsuya,Koga Kaori,Kitade Mari,Fukuda Shinya,Neriishi Kazuaki,Taniguchi Fuminori,Honda Ritsuo,Takazawa Naoko,Tanaka Toshiaki,Kurihara Masatoshi,Nakajima Jun,Horie Shigeo,Nakai Hidekatsu,Enomoto Takayuki,Mandai Masaki,Narahara Hisashi,Kitawaki Jo,Harada Tasuku,Katabuchi Hidetaka,Yoshimura Kotaro,Osuga Yutaka
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Journal Title
Journal of Minimally Invasive Gynecology
Volume: 27
Issue: 1
Pages: 80-87
DOI
Related Report
Peer Reviewed
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