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Effect of tamoxifen administration on endometrial implantation in breast cancer patients and analysis of its mechanism of action

Research Project

Project/Area Number 17K11223
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKanazawa University

Principal Investigator

YAMAZAKI RENA  金沢大学, 附属病院, 助教 (80507062)

Co-Investigator(Kenkyū-buntansha) 藤原 浩  金沢大学, 医学系, 教授 (30252456)
大黒 多希子  金沢大学, 学際科学実験センター, 教授 (30767249)
保野 由紀子  金沢大学, 大学病院, その他 (80565416)
井口 雅史  金沢医科大学, 大学病院, 准教授 (90401918)
毎田 佳子  金沢大学, 保健学系, 教授 (20397219)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsタモキシフェン / 子宮内膜 / 卵巣過剰刺激 / 子宮内膜異常 / 乳癌
Outline of Final Research Achievements

1Background:Tamoxifen (TAM), the hormone therapy for premenopausal breast cancer patients, has been previously reported to have ovarian hyperstimulation. We have previously reported that among Japanese young women with breast cancer, ovarian stimulation by TAM is strongly present. In addition, the idea is that the endometrium under TAM administration is directly stimulated by TAM, which not only induces endometrial cancer but also induces a new pathological condition of infertility. 2 Purpose: Analyzing the mechanism of action of ovarian hyperstimulation and endometrium change by TAM. 3Method: Retrospective and prospective view of ovarian hyperstimulation and the thickening and abnormality (polyp,Swiss-cheeselike )of the endometrium.4Result:The incidence and pattern of ovarian hyperstimulation by TAM administration method (Gn-RHa combination, after chemotherapy) and age were clarified. It was clarified that endometrial abnormalities due to TAM administration appeared in almost half.

Academic Significance and Societal Importance of the Research Achievements

閉経前の乳癌患者に対するホルモン治療の第一選択であるタモキシフェン(TAM)には,高頻度で卵巣過剰刺激作用があること、またTAM投与方法や年齢により出現率やパターンが違うことが明らかになり、47歳未満、また、単独投与では50歳以上でも注意しなければならないことが分かった。また、TAM投与下の子宮内膜は、半数近くに肥厚を認め、TAMの直接作用による変化を受けていることがわかった。この変化は、年齢に関係なく、妊孕性温存が必要な若年にも影響を与えており、乳癌治療後の妊娠率低下の原因は卵巣機能低下に加えて子宮内膜胚受容機能低下も関わっていることが分かった。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2020 2019 2017

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (4 results)

  • [Journal Article] Ovarian hyperstimulation closely associated with resumption of follicular growth after chemotherapy during tamoxifen treatment in premenopausal women with breast cancer: A multicenter retrospective cohort study2020

    • Author(s)
      Rena Yamazaki1, Masafumi Inokuchi2, Satoko Ishikawa3, Takuya Ayabe4, Hiromitsu Jinno5, Takashi Iizuka1,
    • Journal Title

      BMC cancer

      Volume: 20 Issue: 1

    • DOI

      10.1186/s12885-020-6549-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of circulating tumor cells in cervical cancer using a conditionally2017

    • Author(s)
      Takakura M, Matsumoto T, Nakamura M, Mizumoto Y, Myojyo S, Yamazaki R, Iwadare
    • Journal Title

      Cancer Sci.ence

      Volume: 109(1) Issue: 1 Pages: 231-240

    • DOI

      10.1111/cas.13449

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Giant fetal hydrometrocolpos associated with cloacal anomaly causing postnatal respiratory distress2017

    • Author(s)
      Kanda Tatsuhito、Iizuka Takashi、Yamazaki Rena、Iwadare Junpei、Ono Masanori、Fujiwara Hiroshi
    • Journal Title

      JOURNAL OF OBSTETRICS GYNAECOLOGY RESEARCH

      Volume: 43 Issue: 11 Pages: 1769-1772

    • DOI

      10.1111/jog.13433

    • NAID

      120006343947

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 婦人科医の視点からみた乳癌ホルモン療法の生殖器への影響 当院の症例より2019

    • Author(s)
      Rena Yamazaki
    • Organizer
      日本がん・生殖医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 当院における乳癌患者に対するタモキシフェンの卵巣過剰刺激作用の調査(2019

    • Author(s)
      Rena Yamazaki
    • Organizer
      日本女性医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 性成熟期乳がん患者におけるタモキシフェンの子宮内膜へ与える作用の調査2019

    • Author(s)
      Rena Yamazaki
    • Organizer
      日本生殖医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 閉経前乳癌におけるタモキシフェンによる卵巣過剰刺激(多施設共同後ろ向き観察研究)2019

    • Author(s)
      井口雅史, 山崎玲奈, 綾部琢哉, 内田聡子, 杉江知治, 松崎利也, 石川聡子, 藤原浩
    • Organizer
      日本癌治療学会
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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