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A treatment strategy for gastrointestinal development of extremely premature infants: Administration of micelles derived from pulmonary surfactants and vernix caseosa in a pregnant animal model

Research Project

Project/Area Number 17K11224
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNiigata University (2019)
Fukui Prefectural University (2018)
University of Fukui (2017)

Principal Investigator

Nishijima Koji  新潟大学, 医歯学総合病院, 准教授 (80334837)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肺サーファクタント / 胎脂 / ミセル / 早産児 / 低出生体重児 / 壊死性腸炎 / 体内分布評価 / 早産 / 超低出生体重児 / 超早産児 / 超早産
Outline of Final Research Achievements

We prepared 125I-labeled bovine pulmonary surfactant TA (STA; Mitsubishi Tanabe Pharma Corp., Osaka, Japan) using 125I-Succinimidyl-3-iodobenzoate. We then infused the 125I-labeled STA into the amniotic fluid space of pregnant Japanese white rabbits on gestational day 27 (right-ovarian-end fetuses). The 125I-labeled STA were transferred to maternal blood at 30 minutes post-dose, and most were excreted in the urine. The 125I-labeled STA were also transferred to all internal organs of all fetuses, and especially, highly accumulated at fetal stomach, gastric juices, and intestine. We speculate that the existence of highly-concentrated pulmonary surfactants in the neonatal gastrointestinal tracts just after the birth is important for neonatal immunocompetence acquisition processes. Although further studies are needed, our findings elucidate the physiological interactions among pulmonary, dermal-epidermal, and gastrointestinal developmental processes.

Academic Significance and Societal Importance of the Research Achievements

妊娠後期の羊水構成成分の変化と消化管成熟との関連に着目した研究は、国内外を通じて存在しない。報告者の作成したサーファクテンミセル溶液(特許第4378531号)は、ウサギ胎仔小腸の成長と保護に関与し、ラット新生仔の壊死性腸炎発症を抑制した。今日の未熟児医療における最大の問題点の一つは、消化管の未熟性に起因する壊死性腸炎の発症である。少子高齢化社会においては、早産児を“後遺症なく生存”させることの意義はきわめて大きい。本研究を進めることで、新たな視点に立った初期経腸栄養剤の開発が期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2017 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (2 results)

  • [Journal Article] Biology of the Vernix Caseosa: A Review2019

    • Author(s)
      Nishijima K, Yoneda M, Hirai T, Takakuwa K, Enomoto T.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 45 Issue: 11 Pages: 2145-2149

    • DOI

      10.1111/jog.14103

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 早産期の消化管保護に向けた治療戦略~肺サーファクタントと胎脂に着目して~2019

    • Author(s)
      西島浩二
    • Organizer
      第7回新潟ペリネイタル研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新生児壊死性腸炎モデルにおける脱分化脂肪細胞の治療効果についての検討.2019

    • Author(s)
      見松はるか, 佐藤義朗, 松本太郎, 風間智彦, 西島浩二, 下山芳江,上田一仁, 三浦良介, 呉尚治, 北瀬悠磨, 鈴木俊彦, 早川昌弘
    • Organizer
      第18回日本再生医療学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Development of a novel therapy using dedifferentiated fat cells for necrotizing enterocolitis in neonates.2019

    • Author(s)
      Haruka Mimatsu, Yoshiaki Sato, Tomohiko Kazama, Koji Nishijima, Yoshie Shimoyama, Kazuto Ueda, Ryosuke Miura, Shoji Go, Yuma Kitase, Toshihiko Suzuki, Yoshiyuki Takahashi, Taro Matsumoto, Masahiro Hayakawa.
    • Organizer
      Pediatric Academic Societies 2019 Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新生児壊死性腸炎における幹細胞療法の開発.2018

    • Author(s)
      見松はるか, 佐藤義朗, 上田一仁, 三浦良介, 呉尚治, 北瀬悠磨, 鈴木俊彦, 西島浩二, 早川昌弘
    • Organizer
      第63回日本新生児・成育医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 早産児の消化管保護に向けた治療戦略:肺サーファクタントと胎脂を用いた動物実験2017

    • Author(s)
      西島浩二
    • Organizer
      第53回日本周産期・新生児医学会学術集会ミニシンポジウム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Remarks] 受験生のためのFUKUDAI LIFE 産婦人科医の視点から新生児を治療する

    • URL

      https://www.u-fukui.ac.jp/voice/9687/

    • Related Report
      2018 Research-status Report
  • [Remarks] 超低出生体重児の消化管保護に向けた治療戦略:肺サーファクタントと胎脂を用いた動物実験

    • URL

      http://sankafujinka.com/intro/reserch2.html

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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