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Participation of and regulatory B cells, dendritic cells, and natural killer cells in recurrent pregnancy loss

Research Project

Project/Area Number 17K11234
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKobe University

Principal Investigator

Deguchi Masashi  神戸大学, 医学研究科, 特命教授 (50403291)

Co-Investigator(Kenkyū-buntansha) 山田 秀人  神戸大学, 医学研究科, 教授 (40220397)
森實 真由美  神戸大学, 医学研究科, 講師 (50514692)
谷村 憲司  神戸大学, 医学部附属病院, 准教授 (80593988)
蝦名 康彦  神戸大学, 医学研究科, 医学研究員 (90322809)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords不育症 / 染色体正常流産 / 脱落膜 / 末梢血 / マクロファージ / NK細胞 / 制御性B細胞 / 生殖医学 / 樹状細胞
Outline of Final Research Achievements

CD94+ natural killer (NK) cells and CD43+ CD27 high B cells show a tendency to increase in the peripheral blood of women with recurrent pregnancy loss (RPL) compared with women without pregnancy loss. In the deciduae, M1 macrophages increased in miscarriages with normal fetal chromosome compared with miscarriages with abnormal fetal chromosome or induced abortion. M2 macrophages. M2 polarization in deciduae is favorable for the maintenance of early stages of pregnancy. As for CD44 expression of NK cells, CD44 expression in peripheral blood NK cell was not changed in RPL women, but CD44+ uterine NK cells show a tendency to increase in the deciduae of miscarriages with normal fetal chromosome. Cytotoxic CD44+ NK cells in the deciduae might be a more impoprtant factor than that in peripheral blood during nonpregnant period.

Academic Significance and Societal Importance of the Research Achievements

受精卵が初めて母体と接する子宮の脱落膜と、簡単に検査できる非妊時の血液で流産と関係する免疫細胞のバランス変化について調査した。血液では予想外に自己免疫反応を抑制する制御性B細胞や、腫瘍等の細胞障害能力が弱いNK細胞が流産を繰り返す人で多い傾向があった。一方、流産脱落膜では子宮NK細胞でも細胞障害能力が強いタイプ多い傾向にあり、腫瘍等の増殖を助けるM2タイプのマクロファージが明らかに少なかった。
妊娠時の脱落膜ではマクロファージやNK細胞が流産と関わることが明らかになりましたが、それを非妊時の血液検査で容易に推定することは難しく、妊娠時の採血などより多角的な検討が必要と考えられた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report

Research Products

(13 results)

All 2019 2018 2017

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results)

  • [Journal Article] Clinical factors associated with pregnancy outcome in women with recurrent pregnancy loss2019

    • Author(s)
      Miyaji Maho、Deguchi Masashi、Tanimura Kenji、Sasagawa Yuki、Morizane Mayumi、Ebina Yasuhiko、Yamada Hideto
    • Journal Title

      Gynecol Endocrinol

      Volume: 35 Pages: 1-6

    • DOI

      10.1080/09513590.2019.1604657

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of high-dose i.v. immunoglobulin therapy for pregnant women with aspirin-heparin-resistant secondary antiphospholipid syndrome2018

    • Author(s)
      Maesawa Yoko、Deguchi Masashi、Tanimura Kenji、Morizane Mayumi、Ebina Yasuhiko、Yamada Hideto
    • Journal Title

      Reprod Med Biol

      Volume: 17 Pages: 149-154

    • DOI

      10.1002/rmb2.12080

    • NAID

      120006716620

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Factors associated with adverse pregnancy outcomes in women with systematic lupus erythematosus2018

    • Author(s)
      Deguchi Masashi、Maesawa Yoko、Kubota Shino、Morizane Mayumi、Tanimura Kenji、Ebina Yasuhiko、Yamada Hideto
    • Journal Title

      J Reprod Immunol

      Volume: 125 Pages: 39-44

    • DOI

      10.1016/j.jri.2017.11.005

    • NAID

      120006604675

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decidual CD68+HLA-DR+CD163? M1 macrophages increase in miscarriages with normal fetal chromosome2018

    • Author(s)
      Shimada Shigeki、Ebina Yasuhiko、Iijima Norifumi、Deguchi Masashi、Yamada Hideto
    • Journal Title

      Am J Reprod Immunol.

      Volume: 79 Pages: 1-5

    • DOI

      10.1111/aji.12791

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 不育症の診断と治療2019

    • Author(s)
      出口雅士
    • Organizer
      尼崎市産婦人科医会学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 血栓性素因と妊娠2019

    • Author(s)
      出口雅士
    • Organizer
      第20回日本検査血液学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Management of pregnancies complicated by systemic lupus erythematosus and antiphospholipid antibody syndrome.2019

    • Author(s)
      Deguchi M
    • Organizer
      14th World Congress of the International Society for Immunology of Reproduction/ The 34th Annual Meeting of the Japanese Society for Immunology of Reproduction
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Decidual CD68+HLA-DR+CD163- M1 macrophages increase in miscarriages with normal fetal chromosome.2019

    • Author(s)
      Shimada S, Ebina Y, Iijima N, Deguchi M, Yamada H
    • Organizer
      14th World Congress of the International Society for Immunology of Reproduction/ The 34th Annual Meeting of the Japanese Society for Immunology of Reproduction
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The distribution of etiology and therapy outcomes of recurrent pregnancy loss at our recurrent pregnancy loss clinic2018

    • Author(s)
      Miyaji M, Deguchi M, Tanimura K, Morizane M, Ebina Y, Yamada H
    • Organizer
      第70回日本産科婦人科学会学術講演会 仙台
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 【教育講演】不育症診療の現状と課題~さらなる妊娠予後改善にむけて~2018

    • Author(s)
      出口雅士、山田秀人
    • Organizer
      第59回日本母性衛生学会総会・学術集会 新潟
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 神戸大学における不育症の臨床因子と妊娠予後の検討2018

    • Author(s)
      宮地真帆、出口雅士、今福仁美、谷村憲司、森實真由美、蝦名康彦、山田秀人
    • Organizer
      第59回日本母性衛生学会総会・学術集会 新潟
    • Related Report
      2018 Research-status Report
  • [Presentation] 妊娠初期のプロテイン S 低値と産科異常との関連2018

    • Author(s)
      出口雅士、谷村憲司、蝦名康彦、山田秀人
    • Organizer
      第33回日本生殖免疫学会総会・学術集会 東京
    • Related Report
      2018 Research-status Report
  • [Presentation] 染色体正常流産の子宮脱落膜ではM1マクロファージが増加している2017

    • Author(s)
      島田茂樹、蝦名康彦、出口雅士、山田秀人
    • Organizer
      第32回日本生殖免疫学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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