HLA class II complex antibody in recurrent pregnancy loss and pregnancy complications
| Project/Area Number |
17K11235
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kobe University |
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Principal Investigator |
Yamada Hideto 神戸大学, 医学研究科, 非常勤講師 (40220397)
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| Co-Investigator(Kenkyū-buntansha) |
出口 雅士 神戸大学, 医学研究科, 特命教授 (50403291)
谷村 憲司 神戸大学, 医学部附属病院, 准教授 (80593988)
蝦名 康彦 神戸大学, 医学研究科, 医学研究員 (90322809)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 不育症 / 不妊症 / 胎児発育不全 / 妊娠高血圧症候群 / ネオ・セルフ抗体 / 抗リン脂質抗体症候群 / ネオセルフ抗体 / 抗リン脂質抗体 / HLA class II |
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| Outline of Final Research Achievements |
The aim of this study was to evaluate association between aβ2GPI/HLA-DR7 complex antibody and recurrent pregnancy loss (RPL), infertility, and pregnancy complications. Fifty-two (22.9%) of 227 women with RPL, 24 (19.8%) of 121 women with unexplained RPL, and 22 (19.3%) of 114 women with APS symptoms but not aPL tested positive for the neo-self antibody. 19% of FGR, 14% of HDP, 8% of premature delivery at 34 or less weeks of gestation, 12% of infertility also tested positive for the antibody. The neo-self antibody may be involved in the pathogenesis of RPL, infertility, as well as pregnancy complications.
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| Academic Significance and Societal Importance of the Research Achievements |
ネオ・セルフ抗体は、不育症、不妊症、産科異常の原因である可能性があることを世界で初めて明らかにした。これまで原因/リスク因子不明とされていた不育症女性の19.8％で陽性になったことから、ネオ・セルフ抗体は、新たな不育症の原因である可能性を示した。また、これまで抗体陽性の不育症で治療した18人では、低用量アスピリンや低用量アスピリン+ヘパリン治療によって、健児を得ている。前向きコホート研究や介入研究の臨床試験によって、因果関係の決定と治療方法の確立が期待される。
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Report
(5 results)
Research Products
(49 results)
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[Journal Article] The beta(2)-Glycoprotein I/HLA-DR Complex As A Major Autoantibody Target in Obstetric Antiphospholipid Syndrome2020
Author(s)
[Kenji Tanimura,Shigeru Saito,Mikiya Nakatsuka,Takeshi Nagamatsu,Tomoyuki Fujii,Atsushi Fukui,Masashi Deguchi,Yuki Sasagawa,Noriko Arase,Hisashi Arase,Hideto Yamada]
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Journal Title
ARTHRITIS & RHEUMATOLOGY
Volume: 72
Issue: 11
Pages: 1882-1891
DOI
Related Report
Peer Reviewed
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[Presentation] Autoantibody against β2-glycoprotein I/HLA class II complexes as a new marker for antiphospholipid syndrome. Tanimura K, Sasagawa Y, Imafuku H, Morizane M, Deguchi M, Arase H, Yamada H.2020
Author(s)
Tanimura K, Sasagawa Y, Imafuku H, Morizane M, Deguchi M, Arase H, Yamada H.
Organizer
第72回日本産科婦人科学会学術講演会
Related Report
Int'l Joint Research
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