Multi-center prospective study for elucidation of gene-environment interaction of hypertenxsion in pregnmancy
| Project/Area Number |
17K11249
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
Kobashi Gen 獨協医科大学, 医学部, 教授 (60270782)
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| Co-Investigator(Kenkyū-buntansha) |
梅澤 光政 獨協医科大学, 医学部, 准教授 (00567498)
宮下 進 獨協医科大学, 医学部, 教授 (20743165)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 妊娠高血圧症候群 / 弛緩出血 / 危険要因 / 分子疫学 / 遺伝環境交互作用 / 酸化ストレス / 血中ビタミンD |
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| Outline of Final Research Achievements |
The present study revealed that genetic polymorphisms of oxtosin receptor gene and prostaglandin endoperoxide synthase-2 gene were associated with postpartum hemorrhage.Analyses clarifying assosiations between hypertension in pregnancy and sleeping habit, job stress, social-economic status, etc. were carried out, as well as drinking and smoking habit, physical activities, and urinary 8-hydroxy-2’-deoxyguanosine 1 levels as a stress marker. Furter, it was shown that gestational hypertension was a risk factor of hypertension in middle-aged and older women.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は、妊娠高血圧症候群、弛緩出血といった主要な周産期合併症の新しい予防対策、すなわち、妊婦の健康意識が高く生活習慣の把握が容易な妊婦検診の場で、妊娠初期の遺伝子タイピングによる①ハイリスク群の抽出、②個別の生活習慣指導、③酸化ストレスマーカー測定等による発症予知・早期治療、④治療法の選択、長期予後の推定といった、「エビデンスに基づいたテーラーメイド周産期医療」実現に向けた基礎資料となる。
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Report
(4 results)
Research Products
(8 results)
