| Project/Area Number |
17K11258
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
SHOJI Hiroki 金沢医科大学, 一般教育機構, 教授 (10263873)
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| Co-Investigator(Kenkyū-buntansha) |
有川 智博 東北医科薬科大学, 医学部, 准教授 (70452670)
酒井 大輔 金沢医科大学, 一般教育機構, 講師 (90632646)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ガレクチン / 胎盤 / 浸潤 / 栄養膜細胞 / EMT / 浸潤能 / 胎盤形成 |
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| Outline of Final Research Achievements |
Galectins are known as beta-galactoside binding animal lectins, and nineteen members have been identified in mammals. In this study, we aimed to clarify the roles of galectins in during differentiation of invasive cells using trophoblast cell lines and lung epithelial cells as model systems. Together with previous research, it was suggested that galectins 1, 3 & 9 promote, and galectins 4 & 8 suppress the the acquisition of invasiveness.
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| Academic Significance and Societal Importance of the Research Achievements |
妊娠高血圧症候群は全妊娠の7-10％と比較的高頻度に認められ、原因解明は急務である。最近、妊娠初期におけるinvasive trophoblastによるらせん動脈のリモデリング異常が主因であることが判明しつつあるが、その分子機序は不明な点が多い。本研究の成果は、こうした病態発症の分子機序への理解を深め、ひいては予防法や治療法の開発研究への貢献が期待できる。さらに、浸潤能獲得制御の解明は、ガンの理解や治療法研究に貢献出来る可能性もある。
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