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Development of a new treatment method using glycolipids for anticancer drug-resistant cancer in gynecologic cancers

Research Project

Project/Area Number 17K11295
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionToho University (2018-2021)
Keio University (2017)

Principal Investigator

TANAKA KYOKO  東邦大学, 医学部, 教授 (10286536)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords子宮内膜癌 / 子宮頸癌 / 卵巣癌 / 糖脂質 / 抗癌剤耐性 / 遺伝子導入 / 子宮頸癌由来細胞株 / ガングリオシド / ヌードマウス / 皮下移植 / 抗癌剤感受性 / 婦人科癌 / 抗がん剤耐性 / 糖鎖
Outline of Final Research Achievements

We investigated glycolipid composition in gynecological cancer tissues (endometrial cancer, cervical cancer, and ovarian cancer) and found that each cancer has a characteristic composition. In endometrial cancer, sulfatide synthase genes were introduced into endometrial cancer-derived cells, and sulfatide was found to be an indicator of anticancer sensitivity and drug resistance. In cervical cancer, GM2 was found to be a key factor for cancer growth by comparing cell lines and cancer tissues.

Academic Significance and Societal Importance of the Research Achievements

細胞の癌化に伴う複合糖鎖の変化はすべての癌細胞に観察され、消化管、内分泌器官などの癌細胞では特定の糖鎖が腫瘍マーカーとして癌の臨床診断に用いられている。本研究では子宮内膜癌、子宮頸癌、卵巣癌における糖脂質の組成を解析し、癌細胞の転移、抗がん剤耐性への糖鎖の関与を明らかにしたことで癌の治療効果を高めるための基礎研究を行うことができた。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2022 2021 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Characterization of a novel glycolipid with a difucosylated H-antigen in human blood group O erythrocytes with monoclonal antibody HMMC-1 and its detection in human uterine cervical carcinoma tissues2019

    • Author(s)
      Tanaka K, Suzuki A, Aoki D, Iwamori M
    • Journal Title

      Glycoconj J.

      Volume: 36(3) Issue: 3 Pages: 219-226

    • DOI

      10.1007/s10719-019-09873-3

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of the MDR1 gene and glycolipids in anticancer drug-resistance of human ovarian carcinoma-derived cells2019

    • Author(s)
      Tanaka K, Kiguchi K, Mikami M, A Aoki D, Iwamori M
    • Journal Title

      Human cell

      Volume: 32(4) Issue: 4 Pages: 447-452

    • DOI

      10.1007/s13577-019-00261-5

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effective Selection of a Well-Differentiated Type of Human Uterine Endometrial Carcinoma Cells by Transfection of the Sulfotransferase Gene and Possible Association of Sulfoglycolipids with Well-Differentiated Phenotypes2017

    • Author(s)
      Tanaka K, Ishiwata I, Kubushiro K, Mikami M, Aoki D, Kiguchi K, Iwamori M
    • Journal Title

      Int J Gynecol Cancer

      Volume: 27(2) Pages: 267-273

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] ヌードマウスへの皮下移植後の子宮頸癌由来細胞におけるGM2決定基によるガングリオシドの発現低下2022

    • Author(s)
      田中京子
    • Organizer
      第82回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ヒト卵巣癌由来細胞の抗がん剤耐性におけるMRD1遺伝子と糖脂質の関与2021

    • Author(s)
      田中京子
    • Organizer
      第40回大田地区産婦人科研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 卵巣癌由来細胞の糖脂質組成改変による抗腫瘍効果の変化2018

    • Author(s)
      田中京子, 村上 功, 岩田 卓, 青木大輔, 岩森正男
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 抗HMMC-1抗体によるヒト子宮頸癌組織におけるジフコシルH抗原の検出2017

    • Author(s)
      田中京子,村上 功,岩田 卓,青木大輔,岩森正男
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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