| Project/Area Number |
17K11307
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
Takuya Murata 川崎医科大学, 医学部, 准教授 (20714207)
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| Co-Investigator(Kenkyū-buntansha) |
中村 隆文 川崎医科大学, 医学部, 教授 (20303969)
下屋 浩一郎 川崎医科大学, 医学部, 教授 (40291950)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 転移 / がん関連線維芽細胞 / 子宮頸がん / リンパ節転移 / ヌードマウス皮下移植 / 蛍光イメージ / がんの微小環境 / 子宮頸癌 |
|---|
| Outline of Final Research Achievements |
Trans membrane protein TM4SF1 and protein X was upregulated in cervical cancer-associated fibroblast (CAF) that had ability to induce cervical cancer cell line ME180 metastasize to the lymph node in nude mouse xenograft model. We screened Chb-PIP library and Chb-PIP-T strongly inhibited transcription of both TM4SF1 and protein X genes. We found that Chb-PIP-T inhibited the lymph node metastasis of ME180 in nude mouse co-transplantation xenograft model with statistical significance (p=0.020).
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| Academic Significance and Societal Importance of the Research Achievements |
転移抑制剤が開発されれば、子宮頸がんの予後が著しく改善され、子宮頸がんの進行や再発に苦しむ患者さんにとって大きな福音となる。
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