Mechanisms of human papillomavirus carcinogenesis mediated by TEAD4

• Project/Area Number: 17K11309
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: KUKIMOTO IWAO 国立感染症研究所, 病原体ゲノム解析研究センター, 室長 (70291127)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ヒトパピローマウイルス / 子宮頸がん / TEAD4 / Rb / HPV / E7 / RNA-seq / 子宮頸癌 / パピローマウイルス / APOBEC / 癌 / 感染症 / ウイルス

Outline of Final Research Achievements

The human papillomavirus oncoprotein E7 is known to induce APOBEC3B gene expression, but the molecular mechanism is not clear. In this study, we show that E7 induces expression of the cellular transcription factor TEAD4 via binding to and degradation of Rb. TEAD4 is involved in APOBEC3B gene expression, suggesting that E7 induces APOBEC3B via TEAD4. E7s, encoded by three HPV16 variants (A1, A4, and A5) showing different risks of cervical cancer progression, were also found to alter expression patterns of different cellular genes.

Academic Significance and Societal Importance of the Research Achievements

ヒトパピローマウイルス（HPV）の持続感染は子宮頸癌の原因であることから、HPV感染による子宮頸癌の発症メカニズムを解明することは、子宮頸癌の新たな治療・予防法の開発に結びつくと考えられる。本研究で、HPV癌タンパク質E7が細胞癌化を引き起こす分子機構の一端が明らかになり、HPV発癌機構の理解が進むことが期待される。

Research Products

• [Journal Article] Ancient Evolutionary History of Human Papillomavirus Type 16, 18 and 58 Variants Prevalent Exclusively in Japan. (2022)
  • Author(s): Tanaka K, Kogure G, Onuki M, Matsumoto K, Iwata T, Aoki D, Kukimoto I.
  • Journal Title: Viruses Volume: 14 Issue: 3 Pages: 464-464
  • DOI: 10.3390/v14030464
  • Peer Reviewed / Open Access
• [Journal Article] Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program. (2022)
  • Author(s): Onuki M, Matsumoto K, et al. for The Mint Study Group.
  • Journal Title: Vaccines (Basel) Volume: 10 Issue: 2 Pages: 181-181
  • DOI: 10.3390/vaccines10020188
  • Peer Reviewed / Open Access
• [Journal Article] Human papillomavirus vaccine effectiveness by age at first vaccination among Japanese women. (2022)
  • Author(s): Onuki M, Matsumoto K, et al. for The MINT Study Group.
  • Journal Title: Cancer Science Volume: 113 Issue: 4 Pages: 1428-1434
  • DOI: 10.1111/cas.15270
  • Peer Reviewed / Open Access
• [Journal Article] Interferon-gamma induced APOBEC3B contributes to Merkel cell polyomavirus genome mutagenesis in Merkel cell carcinoma (2021)
  • Author(s): Que L, Li Y, Dainichi T, Kukimoto I, Nishiyama T, Nakano Y, Shima K, Suzuki T, Sato Y, Horike S, Aizaki H, Watashi K, Kato T, Aly HH, Watanabe N, Kabashima K, Wakae K, Muramatsu M.
  • Journal Title: J Invest Dermatol Volume: S0022-202X(21) Issue: 7 Pages: 02636-1
  • DOI: 10.1016/j.jid.2021.12.019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Transcription Factor Homeobox D9 Drives the Malignant Phenotype of HPV18-Positive Cervical Cancer Cells via Binding to the Viral Early Promoter (2021)
  • Author(s): Hayashi S, Iwata T, Imagawa R, Sugawara M, Chen G, Tanimoto S, Sugawara Y, Tanaka I, Matsui T, Nishio H, Nakamura M, Katoh Y, Mori S, Kukimoto I, Aoki D.
  • Journal Title: Cancers (Basel) Volume: 13(18) Issue: 18 Pages: 4613-4613
  • DOI: 10.3390/cancers13184613
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of prevalence of <i>Felis catus</i> papillomavirus type 2 in squamous cell carcinomas in cats between Taiwan and Japan (2021)
  • Author(s): Yamashita-Kawanishi N, Chang CY, Chambers JK, Uchida K, Sugiura K, Kukimoto I, Chang HW, Haga T.
  • Journal Title: Journal of Veterinary Medical Science Volume: 83 Issue: 8 Pages: 1229-1233
  • DOI: 10.1292/jvms.21-0153
  • NAID: 130008072092
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access
• [Journal Article] Changes to the cervicovaginal microbiota and cervical cytokine profile following surgery for cervical intraepithelial neoplasia (2021)
  • Author(s): Kawahara R, Fujii T, Kukimoto I, Nomura H, Kawasaki R, Nishio E, Ichikawa R, Tsukamoto T, Iwata A.
  • Journal Title: Sci Rep Volume: 11 Issue: 1 Pages: 2156-2156
  • DOI: 10.1038/s41598-020-80176-6
  • Peer Reviewed / Open Access
• [Journal Article] High Levels of Within-Host Variations of Human Papillomavirus 16 E1/E2 Genes in Invasive Cervical Cancer (2020)
  • Author(s): Hirose Yusuke、Yamaguchi-Naka Mayuko、Onuki Mamiko、Tenjimbayashi Yuri、Tasaka Nobutaka、Satoh Toyomi、Tanaka Kohsei、Iwata Takashi、Sekizawa Akihiko、Matsumoto Koji、Kukimoto Iwao
  • Journal Title: Frontiers in Microbiology Volume: 11 Pages: 596334-596334
  • DOI: 10.3389/fmicb.2020.596334
  • Peer Reviewed / Open Access
• [Journal Article] Use of Cap Analysis Gene Expression to detect human papillomavirus promoter activity patterns at different disease stages (2020)
  • Author(s): Taguchi A, Nagasaka K, Plessy C, Nakamura H, Kawata Y, Kato S, Hashimoto K, Nagamatsu T, Oda K, Kukimoto I, Kawana K, Carninci P, Osuga Y, Fujii T.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 17991-17991
  • DOI: 10.1038/s41598-020-75133-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Human Papillomavirus (HPV) Genotyping Assay Suitable for Monitoring the Impact of the 9-Valent HPV Vaccine (2020)
  • Author(s): Kukimoto Iwao、Matsumoto Koji、Takahashi Fumiaki、Iwata Takashi、Tanaka Kohsei、Yamaguchi-Naka Mayuko、Yamamoto Kasumi、Yahata Hideaki、Nakabayashi Makoto、Kato Hisamori、Tsuda Naotake、Onuki Mamiko、Yaegashi Nobuo、MINT Study II Group
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 251 Issue: 4 Pages: 287-294
  • DOI: 10.1620/tjem.251.287
  • NAID: 130007884397
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Molecular epidemiology of human papillomavirus 18 infections in Japanese Women (2020)
  • Author(s): Yamaguchi-Naka Mayuko、Onuki Mamiko、Tenjimbayashi Yuri、Hirose Yusuke、Tasaka Nobutaka、Satoh Toyomi、Morisada Tohru、Iwata Takashi、Sekizawa Akihiko、Matsumoto Koji、Kukimoto Iwao
  • Journal Title: Infection, Genetics and Evolution Volume: 83 Pages: 104345-104345
  • DOI: 10.1016/j.meegid.2020.104345
  • Peer Reviewed
• [Journal Article] Establishment and Molecular Phenotyping of Organoids from the Squamocolumnar Junction Region of the Uterine Cervix (2020)
  • Author(s): Maru Y, Kawata A, Taguchi A, Ishii Y, Baba S, Mori M, Nagamatsu T, Oda K, Kukimoto I, Osuga Y, Fujii T, Hippo Y.
  • Journal Title: Cancers (Basel) Volume: 12 Issue: 3 Pages: 694-694
  • DOI: 10.3390/cancers12030694
  • Peer Reviewed / Open Access
• [Journal Article] Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia (2020)
  • Author(s): Baba S, Taguchi A, Kawata A, Hara K, Eguchi S, Mori M, Adachi K, Mori S, Iwata T, Mitsuhashi A, Maeda D, Komatsu A, Nagamatsu T, Oda K, Kukimoto I, Osuga Y, Fujii T, Kawana K.
  • Journal Title: Virol J Volume: 17 Issue: 1 Pages: 32-32
  • DOI: 10.1186/s12985-020-01306-0
  • NAID: 120007089054
  • Peer Reviewed / Open Access
• [Journal Article] The Transcriptional Cofactor VGLL1 Drives Transcription of Human Papillomavirus Early Genes via TEAD1 (2020)
  • Author(s): Mori S, Takeuchi T, Ishii Y, Kukimoto I.
  • Journal Title: J Virol Volume: 94 Issue: 10
  • DOI: 10.1128/jvi.01945-19
  • Peer Reviewed
• [Journal Article] The homeobox transcription factor HOXC13 upregulates human papillomavirus E1 gene expression and contributes to viral genome maintenance (2020)
  • Author(s): Ishii Y, Taguchi A, Kukimoto I.
  • Journal Title: FEBS Lett Volume: 594 Issue: 4 Pages: 751-762
  • DOI: 10.1002/1873-3468.13646
  • Peer Reviewed
• [Journal Article] Human Papillomavirus Carcinogenesis Mediated by APOBEC Mutagenesis (2019)
  • Author(s): Kukimoto I.
  • Journal Title: YAKUGAKU ZASSHI Volume: 139 Issue: 1 Pages: 75-79
  • DOI: 10.1248/yakushi.18-00164-3
  • NAID: 130007541651
  • ISSN: 0031-6903, 1347-5231
  • Year and Date: 2019-01-01
  • Peer Reviewed / Open Access
• [Journal Article] Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex (2019)
  • Author(s): Masuda Y, Saeki Y, Arai N, Kawai H, Kukimoto I, Tanaka K, Masutani C.
  • Journal Title: J Biol Chem Volume: 294 Issue: 41 Pages: 14860-14875
  • DOI: 10.1074/jbc.ra119.008374
  • Peer Reviewed / Open Access
• [Journal Article] Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter (2019)
  • Author(s): Hirao N, Iwata T, Tanaka K, Nishio H, Nakamura M, Morisada T, Morii K, Maruyama N, Katoh Y, Yaguchi T, Ohta S, Kukimoto I, Aoki D, Kawakami Y.
  • Journal Title: Gynecol Oncol Volume: 155 Issue: 2 Pages: 340-348
  • DOI: 10.1016/j.ygyno.2019.08.026
  • Peer Reviewed / Open Access
• [Journal Article] Cytokine expression profiles in cervical mucus from patients with cervical cancer and its precursor lesions (2019)
  • Author(s): Otani S, Fujii T, Kukimoto I, Yamamoto N, Tsukamoto T, Ichikawa R, Nishio E, Iwata A.
  • Journal Title: Cytokine Volume: 120 Pages: 210-219
  • DOI: 10.1016/j.cyto.2019.05.011
  • Peer Reviewed / Open Access
• [Journal Article] Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions. (2019)
  • Author(s): Hirose Y, Onuki M, Tenjimbayashi Y, Yamaguchi-Naka M, Mori S, Tasaka N, Satoh T, Morisada T, Iwata T, Kiyono T, Mimura T, Sekizawa A, Matsumoto K, Kukimoto I.
  • Journal Title: Viruses Volume: 11 Issue: 4 Pages: 350-350
  • DOI: 10.3390/v11040350
  • NAID: 120007133500
  • Peer Reviewed / Open Access
• [Journal Article] A case of primary signet-ring cell carcinoma of the cervix containing full genome of human papillomavirus 16 (2019)
  • Author(s): Kawai S, Torii Y, Kukimoto I, Fujii T.
  • Journal Title: Indian J Pathol Microbiol. Volume: 62 Issue: 1 Pages: 146-148
  • DOI: 10.4103/ijpm.ijpm_507_17
  • Peer Reviewed / Open Access
• [Journal Article] Preferential digestion of PCNA-ubiquitin and p53-ubiquitin linkages by USP7 to remove polyubiquitin chains from substrates (2019)
  • Author(s): Masuda Y, Kanao R, Kawai H, Kukimoto I, Masutani C.
  • Journal Title: J Biol Chem. Volume: 294 Issue: 11 Pages: 4177-4187
  • DOI: 10.1074/jbc.ra118.005167
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection (2019)
  • Author(s): Takeuchi F, Kukimoto I, Li Z, Li S, Li N, Hu Z, Takahashi A, Inoue S, Yokoi S, Chen J, Hang D, Kuroda M, Matsuda F, Mizuno M, Mori S, Wu P, Tanaka N, Matsuo K, Kamatani Y, Kubo M, Ma D, Shi Y.
  • Journal Title: Hum Mol Genet. Volume: 28 Issue: 2 Pages: 341-348
  • DOI: 10.1093/hmg/ddy390
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of miRNAs in cervical mucus as a novel diagnostic marker for cervical neoplasia (2018)
  • Author(s): Fujii Takuma、Kawai Satoshi、Kukimoto Iwao、Yamada Hiroya、Yamamoto Naoki、Kuroda Makoto、Otani Sayaka、Ichikawa Ryoko、Nishio Eiji、Torii Yutaka、Iwata Aya
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 1-11
  • DOI: 10.1038/s41598-018-25310-1
  • Peer Reviewed / Open Access
• [Journal Article] Within-Host Variations of Human Papillomavirus Reveal APOBEC-Signature Mutagenesis in the Viral Genome (2018)
  • Author(s): Hirose Yusuke、Onuki Mamiko、Tenjimbayashi Yuri、Mori Seiichiro、Ishii Yoshiyuki、Takeuchi Takamasa、Tasaka Nobutaka、Satoh Toyomi、Morisada Tohru、Iwata Takashi、Miyamoto Shingo、Matsumoto Koji、Sekizawa Akihiko、Kukimoto Iwao
  • Journal Title: Journal of Virology Volume: 印刷中 Issue: 12
  • DOI: 10.1128/jvi.00017-18
  • Peer Reviewed / Open Access
• [Journal Article] Whole-genome analysis of human papillomavirus genotypes 52 and 58 isolated from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer (2017)
  • Author(s): Tenjimbayashi Yuri、Onuki Mamiko、Hirose Yusuke、Mori Seiichiro、Ishii Yoshiyuki、Takeuchi Takamasa、Tasaka Nobutaka、Satoh Toyomi、Morisada Tohru、Iwata Takashi、Miyamoto Shingo、Matsumoto Koji、Sekizawa Akihiko、Kukimoto Iwao
  • Journal Title: Infectious Agents and Cancer Volume: 12 Issue: 1 Pages: 44-44
  • DOI: 10.1186/s13027-017-0155-4
  • NAID: 120007128848
  • Peer Reviewed / Open Access
• [Presentation] HPV18型陽性子宮頸部小細胞癌のオルガノイド樹立 オルガノイドが切り拓く希少癌個別化医療 (2021)
  • Author(s): 日下部美佐子, 田口 歩, 谷川道洋, 星 大輔, 豊原佑典, 河田 啓, 曾根献文, 柊元 巌, 織田克利, 筆宝義隆, 大須賀 譲
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 日本人女性から分離されたHPV67の全ゲノム解析 (2021)
  • Author(s): 小暮剛太, 小貫麻美子, 岩田 卓, 松本光司, 柊元 巌
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 子宮頸がんに高発現するmiRNAの検出法は補助診断として有効である (2021)
  • Author(s): 小谷燦璃古, 柊元 巌, 野村弘行, 川原莉奈, 藤井多久麿
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] APOBEC3はメルケル細胞ウイルスゲノムに変異を導入する (2021)
  • Author(s): 若江亨祥, 柊元 巌
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] WHOLE-GENOME ANALYSIS OF POSSIBLY CARCINOGENIC HPV67 ISOLATED FROM JAPANESE WOMEN WITH CERVICAL CANCER/PRECANCER (2021)
  • Author(s): G. Kogure, M. Onuki, T. Iwata, K. Matsumoto, I. Kukimoto.
  • Organizer: 34th International Papillomavirus Conference
  • Int'l Joint Research
• [Presentation] 日本人女性でのHPV18ゲノム配列の分子疫学解析 (2020)
  • Author(s): 柊元 巌, 岩田 卓, 小貫麻美子, 松本光司
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Molecular epidemiology of high-risk HPV infection in Japan (2020)
  • Author(s): Kukimoto I.
  • Organizer: U.S.-Japan Cooperative Medical Sciences Program, Cancer Panel Meeting
  • Int'l Joint Research / Invited
• [Presentation] Identification of unique HPV16 variants prevalent in Japanese women with or without cervical lesions (2019)
  • Author(s): Hirose Y, Tenjimbayashi Y, Yamaguchi-Naka M, Mori S, Onuki M, Iwata T, Kiyono T, Matsumoto K, Kukimoto I.
  • Organizer: DNA Tumour Virus Meeting 2019
  • Int'l Joint Research
• [Presentation] HPV16バリアントと子宮頸癌の進展リスクの関連 (2019)
  • Author(s): Hirose Y, Tenjimbayashi Y, Onuki M, Iwata T, Kiyono T, Matsumoto K, Kukimoto I.
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Sequence analysis of human papillomavirus genotype 18 isolated from Japanese women (2019)
  • Author(s): Naka M, Tenjimbayashi Y, Hirose Y, Onuki M, Iwata T, Matsumoto K, Kukimoto I.
  • Organizer: 第67回日本ウイルス学会学術集会
• [Presentation] Transcriptional factor TEAD1 and its cofactor VGLL1 are required for transcription of HPV16 early genes (2019)
  • Author(s): Mori S, Kukimoto I.
  • Organizer: 第67回日本ウイルス学会学術集会
• [Presentation] The homeobox-transcription factor HOXC13 up-regulates the human papillomavirus early promoter and contributes to viral genome maintenance (2019)
  • Author(s): Ishii Y, Taguchi A, Kukimoto I.
  • Organizer: 第67回日本ウイルス学会学術集会
• [Presentation] APOBEC signature mutagenesis in the genome of human papillomavirus and its relevance to cervical carcinogenesis (2018)
  • Author(s): Hirose Y, Tenjimbayashi Y, Onuki M, Iwata T, Matsumoto K, Kukimoto I.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Analysis of biological differences of human papillomavirus 58 E7 variants (2018)
  • Author(s): Tenjimbayashi Y, Hirose Y, Onuki M, Matsumoto K, Kukimoto I.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] APOBEC signature mutagenesis in HPV16/52/58 genomes and its relevance to cervical carcinogenesis (2018)
  • Author(s): Hirose Y, Tenjimbayashi Y, Onuki M, Iwata T, Matsumoto K, Kukimoto I.
  • Organizer: 32nd International Papillomavirus Conference
  • Int'l Joint Research
• [Presentation] Transcriptional cofactor VGLL1 is required for TEAD-mediated transcription of HPV early genes (2018)
  • Author(s): Mori S, Takeuchi T, Ishii Y, Kukimoto I.
  • Organizer: 32nd International Papillomavirus Conference
  • Int'l Joint Research
• [Presentation] Whole-genome analysis of HPV52/58 isolated from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer (2018)
  • Author(s): Tenjimbayashi Y, Hirose Y, Onuki M, Iwata T, Matsumoto K, Kukimoto I.
  • Organizer: 32nd International Papillomavirus Conference
  • Int'l Joint Research
• [Presentation] HPV16, 18, 52, and 58 differentially express virus-derived transcripts dependent on CIN grade (2018)
  • Author(s): Baba S, Taguchi A, Kawata A, Hara K, Eguchi S, Adachi K, Mori S, Iwata T, Mitsuhashi A, Maeda D, Komatsu A, Nagamatsu T, Oda K, Osuga Y, Fujii T, Kukimoto I, Kawana K.
  • Organizer: 32nd International Papillomavirus Conference
  • Int'l Joint Research
• [Presentation] Infiltration of plasma cells into stroma is possibly associated with higher grade of CIN (2018)
  • Author(s): Kawata A, Taguchi A, Baba S, Eguchi S, Adachi K, Mori S, Iwata T, Mitsuhashi A, Maeda D, Nagamatsu T, Oda K, Osuga Y, Fujii T, Kukimoto I, Kawana K.
  • Organizer: 32nd International Papillomavirus Conference
  • Int'l Joint Research
• [Presentation] APOBEC signature mutagenesis in HPV genomes and its relevance to cervical carcinogenesis (2018)
  • Author(s): Kukimoto I, Hirose Y, Tenjimbayashi Y, Onuki M, Iwata T, Matsumoto K.
  • Organizer: 第66回日本ウイルス学会学術集会
• [Presentation] 転写共役因子VGLL1による転写因子TEADを介したヒトパピローマウイルス初期遺伝子の転写 (2018)
  • Author(s): Mori S, Takeuchi, T, Ishii Y, Kukimoto I.
  • Organizer: 第66回日本ウイルス学会学術集会
• [Presentation] HPV持続感染細胞の探索 (2018)
  • Author(s): Ishii Y, Taguchi A, Kukimoto I.
  • Organizer: 第66回日本ウイルス学会学術集会
• [Presentation] APOBEC変異導入を介したヒトパピローマウイルス発癌機構 (2018)
  • Author(s): 柊元 巌
  • Organizer: 日本薬学会第138年会
  • Invited
• [Presentation] Upregulation of APOBEC3B cytidine deaminase by HPV E6 and E7 via the TEAD transcription factor (2017)
  • Author(s): Kukimoto I, Tenjimbayashi Y, Hirose Y, Onuki M, Matsumoto K, Mori S.
  • Organizer: DNA tumour virus meeting
  • Int'l Joint Research
• [Presentation] Intra-patient variation of human papillomavirus genomes revealed by deep sequencing (2017)
  • Author(s): Hirose Y, Tenjimbayashi Y, Onuki M, Minaguchi T, Iwata T, Matsumoto K, Kukimoto I.
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Whole-genome analysis of human papillomavirus 52 and 58 in Japanese women (2017)
  • Author(s): Tenjimbayashi Y, Hirose Y, Onuki M, Nakao S, Iwata T, Matsumoto K, Kukimoto I.
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] MicroRNAs extracted from cervical mucus or exfoliated cells are promising biomarkers for cervical cancer screening (2017)
  • Author(s): Fujii T, Kukimoto I.
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Whole-genome analysis of human papillomavirus 52/58 isolated from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer (2017)
  • Author(s): Kukimoto I, Tenjimbayashi Y, Hirose Y, Onuki M, Iwata T, Matsumoto K.
  • Organizer: AOGIN 2017
  • Int'l Joint Research
• [Presentation] Whole-genome analysis of HPV52/58 isolated from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer (2017)
  • Author(s): Kukimoto I, Tenjimbayashi Y, Hirose Y, Onuki M, Iwata T, Matsumoto K.
  • Organizer: 第65回日本ウイルス学会学術集会
• [Presentation] Persistent expression of a broadly neutralizing monoclonal antibody against HPVs by AAV-mediated gene transfer (2017)
  • Author(s): Mori S, Kotani O, Takeuchi T, Ishii Y, Kukimoto I.
  • Organizer: 第65回日本ウイルス学会学術集会