| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We analyzed gene expression patterns in the cochlea after insertion of a conventional electrode and a dexamethasone-eluting electrode into the guinea pig cochlea to examine the effects of continuous steroid administration. After insertion of a conventional electrode into the cochlea, damage to the cochlear structure and neurotransmission disorders such as hair cells occurred due to the electrode insertion, resulting in changes in the expression of various genes such as inflammatory cytokines. However, the use of dexamethasone-eluting electrodes suppressed the changes in gene expression, especially the expression of inflammatory cytokines such as TNF-α and IL-1β, which have the potential to damage nerve cells, and thus were thought to be effective in protecting hair cells in the cochlea.
Experiments to examine the functional and morphological effects of long-term electrode implantation in the cochlea using mice were discontinued.
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