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The effects of insulin on maturation process of newly generated olfactory sensory neurons

Research Project

Project/Area Number 17K11354
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

kikuta shu  東京大学, 医学部附属病院, 講師 (00555865)

Co-Investigator(Kenkyū-buntansha) 近藤 健二  東京大学, 医学部附属病院, 准教授 (40334370)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords嗅覚 / インスリン / 嗅上皮 / 細胞死 / 脳・神経 / 生理学 / 臨床
Outline of Final Research Achievements

We examined in adult mice whether insulin signaling affected the dynamic incorporation of newly generated OSNs 7, 14, and 28 days following injury. Between days 7 and 28 post-injury, the STZ-administered diabetic mice showed remarkably fewer OSNs and mature OSNs, but more apoptotic OSNs than the control mice. Insulin administration to the STZ-administered diabetic mice during the period between 8 and 13 days post-injury promoted the recovery of the OE. These results indicate that insulin signaling is involved in homeostatic regeneration of the OE following injury, and that newly generated OSNs have a high susceptibility period to insulin signaling for their maturation between days 8 and 13 post-injury.

Academic Significance and Societal Importance of the Research Achievements

嗅上皮障害後の再生過程に、インスリンシグナルが重要な役割を果たしていることが明らかになれば、嗅上皮障害患者に対する治療法の開発が期待できる。インスリン点鼻投与によって、新生した未熟な嗅神経を効率的に成熟嗅細胞に分化させることができると予想する。本研究は、嗅覚障害患者に対するインスリン点鼻補充療法の臨床応用へと展開するための基盤研究となる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2017

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] High CT attenuation values relative to the brainstem may predict squamous cell carcinoma arising from inverted papilloma2019

    • Author(s)
      Azuma Sanami、Kikuta Shu、Yoshida Masafumi、Ando Mizuo、Kondo Kenji、Yamasoba Tatsuya
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 139 Issue: 11 Pages: 1030-1037

    • DOI

      10.1080/00016489.2019.1659515

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caloric restriction reduces basal cell proliferation and results in the deterioration of neuroepithelial regeneration following olfactotoxic mucosal damage in mouse olfactory mucosa2019

    • Author(s)
      Iwamura Hitoshi、Kondo Kenji、Kikuta Shu、Nishijima Hironobu、Kagoya Ryoji、Suzukawa Keigo、Ando Mizuo、Fujimoto Chisato、Toma-Hirano Makiko、Yamasoba Tatsuya
    • Journal Title

      Cell and Tissue Research

      Volume: 378 Issue: 2 Pages: 175-193

    • DOI

      10.1007/s00441-019-03047-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dorsal-zone-specific reduction of sensory neuron density in the olfactory epithelium following long-term exercise or caloric restriction2018

    • Author(s)
      Tuerdi Ayinuer、Kikuta Shu、Kinoshita Makoto、Kamogashira Teru、Kondo Kenji、Iwasaki Shinichi、Yamasoba Tatsuya
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 17300-17300

    • DOI

      10.1038/s41598-018-35607-w

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] InfraorbitalNerve Located Medially to Postoperative Maxillary Cysts: A Risk of EndonasalSurgery.2018

    • Author(s)
      Kondo K, Baba S, Suzuki S, Nishijima H, Kikuta S, Yamasoba T.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec

      Volume: 20 Issue: 1 Pages: 28-35

    • DOI

      10.1159/000486372

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repetitive Sinus-Related Symptoms May Accelerate the Progression of Chronic Maxillary Atelectasis2017

    • Author(s)
      Kikuta Shu、Horikiri Kyohei、Kanaya Kaori、Kagoya Ryoji、Kondo Kenji、Yamasoba Tatsuya
    • Journal Title

      Case Reports in Otolaryngology

      Volume: 2017 Pages: 1-5

    • DOI

      10.1155/2017/4296195

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 嗅上皮再生を効果的に促進させるインスリンの点鼻投与時期について2019

    • Author(s)
      菊田周、久保木章仁、岸本めぐみ、清水裕也、近藤健二、山岨達也
    • Organizer
      日本鼻科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] インスリン点鼻投与による嗅上皮障害後の再生促進効果について2018

    • Author(s)
      菊田 周、堀切教平、清水裕也、籠谷領二、上羽瑠美、近藤健二、山岨達也
    • Organizer
      日本鼻科学会 学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 日本鼻科学会賞受賞記念講演「Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder」2017

    • Author(s)
      菊田 周
    • Organizer
      第56回日本鼻科学会 総会・学術講演会
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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