| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
Fibrin deposition in nasal polyps (NPs) among patients with eosinophilic chronic rhinosinusitis (ECRS) causes nasal congestion, olfactory dysfunction, and headache. Oral corticosteroid seems to be effective, however, the new strategy for ECRS are required from the point of adverse effects of oral steroid. The down regulation of tissue plasminogen activator (tPA) in nasal epithelial cells is one of the main reasons for fibrin deposition in NPs. In the present study, we demonstrated whether short chain fatty acids (SCFAs) can induce tPA from epithelial cells of not. As a result, we found that SCFAs can induce tPA from nasal epithelial cells.
|
