Functional analysis of short chain fatty acids for eosinophilic chronic rhinosinusitis
Project/Area Number |
17K11355
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | University of Fukui |
Principal Investigator |
Imoto Yoshimasa 福井大学, 学術研究院医学系部門(附属病院部), 助教 (50418703)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 短鎖脂肪酸 / フィブリン / 鼻茸 / tPA / GPR41 / GPR43 / t-PA / 好酸球性副鼻腔炎 |
Outline of Final Research Achievements |
Fibrin deposition in nasal polyps (NPs) among patients with eosinophilic chronic rhinosinusitis (ECRS) causes nasal congestion, olfactory dysfunction, and headache. Oral corticosteroid seems to be effective, however, the new strategy for ECRS are required from the point of adverse effects of oral steroid. The down regulation of tissue plasminogen activator (tPA) in nasal epithelial cells is one of the main reasons for fibrin deposition in NPs. In the present study, we demonstrated whether short chain fatty acids (SCFAs) can induce tPA from epithelial cells of not. As a result, we found that SCFAs can induce tPA from nasal epithelial cells.
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Academic Significance and Societal Importance of the Research Achievements |
短鎖脂肪酸は、腸内細菌が発酵作用で作成したものであり、安全な物質である。本研究では、短鎖脂肪酸が受容体依存性にtPAを誘導すること見出した。この結果から、短鎖脂肪酸受容体のagonistの開発に注目し、今後好酸球性副鼻腔炎の新たな治療薬の可能性が広がることが期待できると考えられる。
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Short-chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41&43.2018
Author(s)
Imoto Y, Kato A, Takabayashi T, Sakashita M, Norton JE, Suh LA, Carter RG, Weibman AR, Hulse KE, Stevens W, Harris KE, Peters AT, Grammer LC, Tan BK, Welch K, Conley DB, Kern RC, Fujieda S, Schleimer RP.
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Journal Title
Clin Exp Allergy.
Volume: 48
Issue: 5
Pages: 544-554
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Serum leptin levels reflect the severity of eosinophilic chronic rhinosinusitis according to Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC Study)2019
Author(s)
Yoshimasa Imoto, Yukinori Kato, Tetsuji Takabayashi, Kanako Yoshida, Takahiro Tokunaga, Taiyo Morikawa, Takahiro Ninomiya, Yumi Ito, Kazuhiro Ogi a, Yukinori Kimura, Masafumi Kanno, Toshiki Tsutsumiuchi, Masafumi Sakashita, Masayuki Okamoto, Norihiko Narita, Shigeharu Fujieda
Organizer
AAAAI Annual meeting
Related Report
Int'l Joint Research
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