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Predictors for long-term effects of SLIT for Japanese pollinosis

Research Project

Project/Area Number 17K11356
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionAkita University

Principal Investigator

Yamada Takechiyo  秋田大学, 医学系研究科, 教授 (70283182)

Co-Investigator(Kenkyū-buntansha) 齋藤 秀和  秋田大学, 医学部附属病院, 助教 (00791948)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords舌下免疫療法 / 長期効果 / 予測因子 / 花粉症 / アレルギー性鼻炎 / アレルギー / SLIT / 抗原 / 気道粘膜 / IgE / スギ花粉症 / バイオマーカー / 予後予測因子 / 網羅的解析 / サイトカイン / 血漿 / 抗原特異的免疫療法 / 長期予後 / 免疫
Outline of Final Research Achievements

We investigated long-term SLIT for Japanese pollinosis as a biomarker for intractable Japanese cedar pollinosis. Symptoms at peak season in Japanese cedar pollen season The drug score is significantly lower in the 3rd to 5th year group than in the 1st year group of SLIT. The serum molecules were comprehensively observed. In the study of sublingual immunotherapy, serum molecules decreased antigen-specific IgE and increased Sugi antigen-specific IgG4 and ApoA-IV in the 4th year compared with the 1st year. Patients who were effective at 4 years had significantly lower pretreatment serum oxidative stress markers. A mouse model of airway allergy was created, and the presence of exhausted type 2 innate lymphoid cells producing IL-10 and the expression of immunomodulatory molecules of type 2 innate lymphoid cells were observed. In a mouse model of airway allergy, TIGIT expression was observed in exhausted type 2 innate lymphoid cells of IL-10 production in the lower respiratory tract.

Academic Significance and Societal Importance of the Research Achievements

研究成果を生かし、薬物効果、手術効果を含めて難治性ダニアレルギー性鼻炎に対する層別化医療、IgE抗体療法の効果や満足度調査、タイプ2サイトカインに対する抗体療法の可能性について、改訂版鼻アレルギー診療ガイドラインへに反映出来る研究を目指す。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (77 results)

All 2021 2020 2019 2018 2017 2016

All Journal Article (25 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 12 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (47 results) (of which Int'l Joint Research: 5 results,  Invited: 40 results) Book (5 results)

  • [Journal Article] Trained innate lymphoid cells in allergic diseases2021

    • Author(s)
      Ebihara T, Tatematsu M, Fuchimukai A, Yamada T, Yamagata K, Takasuga S, Yamada T
    • Journal Title

      Allergology International

      Volume: 70 Issue: 2 Pages: 174-180

    • DOI

      10.1016/j.alit.2020.11.007

    • NAID

      130008024334

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eosinophil ETosis‐mediated release of galectin‐10 in eosinophilic granulomatosis with polyangiitis2021

    • Author(s)
      Fukuchi Mineyo、Kamide Yosuke、Ueki Shigeharu、Miyabe Yui、Konno Yasunori、Oka Nobuyuki、Takeuchi Hiroki、Koyota Souichi、Hirokawa Makoto、Yamada Takechiyo、Melo Rossana C.N.、Weller Peter F.、Taniguchi Masami
    • Journal Title

      Arthritis & Rheumatology

      Volume: 10 Issue: 9 Pages: 41727-41727

    • DOI

      10.1002/art.41727

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] How to detect eosinophil ETosis (EETosis) and extracellular traps2021

    • Author(s)
      4.Fukuchi M, Miyabe Y, Furutani C, Saga T, Moritoki Y, Yamada T, Weller PF, Ueki S.
    • Journal Title

      Allergology International

      Volume: 70 Issue: 1 Pages: 19-29

    • DOI

      10.1016/j.alit.2020.10.002

    • NAID

      130007966786

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The clinical features of intractable allergic rhinitis based on a questionnaire administered to clinicians.2020

    • Author(s)
      2.Imoto Y, Sakashita M, Hayama M, Nakamaru Y, Suzuki M, Miyabe Y, Yamada T, Saito H, Yonekura S, Kondo K, Higaki T, Kawashima K, Urashima M, Fujieda S.
    • Journal Title

      Allergol Int.

      Volume: S1323-8930 Issue: 3 Pages: 373-375

    • DOI

      10.1016/j.alit.2020.12.003

    • NAID

      130008064050

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アレルギーと自然免疫.2020

    • Author(s)
      山田武千代
    • Journal Title

      Journal Otorhinolaryngology Head and Neck Surgery

      Volume: 36 Pages: 289-293

    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Journal Article] アレルギー性鼻炎-私の治療-2020

    • Author(s)
      山田武千代
    • Journal Title

      日本医事新報

      Volume: 4997 Pages: 46-46

    • Related Report
      2019 Research-status Report
    • Open Access / Int'l Joint Research
  • [Journal Article] 耳鼻咽喉科・頭頸部外科の内視鏡治療2020

    • Author(s)
      山田武千代
    • Journal Title

      秋田県医師会雑誌

      Volume: 70 Pages: 25031-25031

    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Journal Article] Eotaxin-3 as a Plasma Biomarker for Mucosal Eosinophil Infiltration in Chronic Rhinosinusitis2019

    • Author(s)
      Yamada Takechiyo、Miyabe Yui、Ueki Shigeharu、Fujieda Shigeharu、Tokunaga Takahiro、Sakashita Masafumi、Kato Yukinori、Ninomiya Takahiro、Kawasaki Yohei、Suzuki Shinsuke、Saito Hidekazu
    • Journal Title

      Frontiers in Immunology

      Volume: 10 Pages: 74-74

    • DOI

      10.3389/fimmu.2019.00074

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of CD16-negative selection vs. MACSxpress system for isolation of blood eosinophils2019

    • Author(s)
      Fukuchi Mineyo、Ueki Shigeharu、Saito Hidekazu、Miyabe Yui、Konno Yasunori、Omokawa Ayumi、Saga Tomoo、Moritoki Yuki、Takeda Masahide、Yamada Takechiyo、Hirokawa Makoto
    • Journal Title

      Allergology International

      Volume: 68 Issue: Supplement.1 Pages: S11-S13

    • DOI

      10.1016/j.alit.2019.04.005

    • NAID

      130007709782

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 血清Nerve growth factor(NGF)と長期スギ舌下免疫療法の効果.2019

    • Author(s)
      山田武千代, 登米慧, 椎名和弘, 斎藤秀和
    • Journal Title

      耳鼻咽喉科ニューロサイエンス

      Volume: 33 Pages: 51-53

    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Journal Article] 好酸球性副鼻腔炎とEotaxin-32019

    • Author(s)
      山田武千代
    • Journal Title

      アレルギーの臨床

      Volume: 39 Pages: 29-34

    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Journal Article] 耳鼻咽喉科が対応する指定難病とアレルギー性鼻炎の治療2019

    • Author(s)
      山田武千代
    • Journal Title

      日本耳鼻咽喉科学会地方部会会報

      Volume: 37 Pages: 5-14

    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Journal Article] Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death2018

    • Author(s)
      Ueki Shigeharu、Tokunaga Takahiro、Melo Rossana C. N.、Saito Hidekazu、Honda Kohei、Fukuchi Mineyo、Konno Yasunori、Takeda Masahide、Yamamoto Yohei、Hirokawa Makoto、Fujieda Shigeharu、Spencer Lisa A.、Weller Peter F.
    • Journal Title

      Blood

      Volume: 132 Issue: 20 Pages: 2183-2187

    • DOI

      10.1182/blood-2018-04-842260

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 気道アレルギー疾患の精密医療2018

    • Author(s)
      山田武千代
    • Journal Title

      耳鼻咽喉科臨床

      Volume: 111 Pages: 151-156

    • NAID

      130006407224

    • Related Report
      2018 Research-status Report
  • [Journal Article] 舌下免疫療法の現状2018

    • Author(s)
      山田武千代
    • Journal Title

      .日本耳鼻咽喉科学会会報

      Volume: 121 Pages: 934-936

    • NAID

      130007428562

    • Related Report
      2018 Research-status Report
  • [Journal Article] 小児難治性疾患-難治性アレルギー性鼻炎-.2018

    • Author(s)
      山田武千代
    • Journal Title

      Journal of Otorhinolaryngology Head and Neck surgery

      Volume: 34 Pages: 1549-1553

    • Related Report
      2018 Research-status Report
  • [Journal Article] 鼻科手術のための検査2018

    • Author(s)
      山田武千代
    • Journal Title

      Journal of Otorhinolaryngology Head and Neck surgery

      Volume: 34 Pages: 1075-1082

    • Related Report
      2018 Research-status Report
  • [Journal Article] 山田武千代2018

    • Author(s)
      アレルギー性鼻炎の診療・臨床研究に関する現状と今後の展望
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 90 Pages: 862-866

    • Related Report
      2018 Research-status Report
  • [Journal Article] 耳鼻咽喉科疾患と免疫系パラダイムシフト2018

    • Author(s)
      山田武千代
    • Journal Title

      秋田医学

      Volume: 45 Pages: 1-5

    • NAID

      120006490189

    • Related Report
      2018 Research-status Report
  • [Journal Article] 耳鼻咽喉科の難治性疾患.2018

    • Author(s)
      山田武千代
    • Journal Title

      耳鼻咽喉科山形

      Volume: 22 Pages: 15-16

    • Related Report
      2018 Research-status Report
  • [Journal Article] Leaflets and continual educational offerings led to increased coverage rate of newborn hearing screening in Akita.2018

    • Author(s)
      Sato Teruyuki,Nakazawa Misao,Takahashi Shin,Mizuno Tomomi,Sato Akira,Noguchi Atsuko,Sato Megumi,Katagiri Sadako,Yamada Takechiyo
    • Journal Title

      Auris Nasus Larynx

      Volume: 45 Issue: 4 Pages: 673-679

    • DOI

      10.1016/j.anl.2017.11.014

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 気道アレルギーの精密医療2018

    • Author(s)
      山田武千代
    • Journal Title

      耳鼻咽喉科臨床

      Volume: 111 Pages: 151-156

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] POU4F3 mutation screening in Japanese hearing loss patients: Massively parallel DNA sequencing-based analysis identified novel variants associated with autosomal dominant hearing loss.2017

    • Author(s)
      Kitano T, Miyagawa M, Nishio SY, Moteki H, Oda K, Ohyama K, Miyazaki H, Hidaka H, Nakamura KI, Murata T, Matsuoka R, Ohta Y, Nishiyama N, Kumakawa K, Furutate S, Iwasaki S, Yamada T, Ohta Y, Uehara N, Noguchi Y, Usami SI.
    • Journal Title

      PLoS One.

      Volume: 12 Issue: 5 Pages: e0177636-e0177636

    • DOI

      10.1371/journal.pone.0177636

    • NAID

      120006373770

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 好酸球性副鼻腔炎の診断基準2017

    • Author(s)
      山田武千代
    • Journal Title

      ENTONI

      Volume: 209 Pages: 8-10

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor ligands induce cytokine and chemokine production in human inner ear endolymphatic sac fibroblasts.2016

    • Author(s)
      Yamada T, Ogi K, Sakashita M, Kanno M, Kubo S, Ito Y, Imoto Y, Tokunaga T, Okamoto M, Narita N, Fujieda S.
    • Journal Title

      Auris Nasus Larynx

      Volume: 44(4) Issue: 4 Pages: 398-403

    • DOI

      10.1016/j.anl.2016.10.007

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 鼻アレルギー診療ガイドラインと難治性副鼻腔炎2021

    • Author(s)
      山田武千代
    • Organizer
      120回鹿児島耳鼻咽喉科学術講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Serum galectin-10 and mucosal eosinophil infiltration in chronic rhinosinusitis.2020

    • Author(s)
      Takechiyo Yamada, Yui Miyabe, Hidekazu Saito, Shigeharu Fujieda, Shigeharu Ueki
    • Organizer
      JSA/WAO Joint Congress 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アレルギー性鼻炎-Type2炎症反応-2020

    • Author(s)
      山田武千代
    • Organizer
      57回日本アレルギー学会専門医認定教育セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 鼻アレルギー診療における抗体製剤の効果について2020

    • Author(s)
      山田武千代
    • Organizer
      宮城県鼻アレルギー診療Teams Interactive Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 花粉症の治療と鼻アレルギー診療ガイドライン2020

    • Author(s)
      山田武千代
    • Organizer
      令和3年佐賀県医師会学術講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 花粉症治療とIgEの関与.2020

    • Author(s)
      山田武千代
    • Organizer
      令和2年 気道アレルギー疾患診療連携講演会 in Akita
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 耳鼻咽喉科疾患におけるI 型アレルギーの病態と治療2020

    • Author(s)
      山田武千代
    • Organizer
      第111回大分耳鼻咽喉科臨床研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 気道アレルギーの病態と治療2020

    • Author(s)
      山田武千代
    • Organizer
      第66回和歌山・泉南アレルギー花粉研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] アレルギー性鼻炎に関する最近の話題2020

    • Author(s)
      山田武千代
    • Organizer
      令和2年アレルギー疾患学術講演会 in 与野
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] I 型アレルギーに関する最近の話題2020

    • Author(s)
      山田武千代
    • Organizer
      アレルギー地域連携フォーラム2020
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 気道アレルギー疾患に対する新たなアプローチ2020

    • Author(s)
      山田武千代
    • Organizer
      第27回東海耳鼻咽喉科生体防御研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Plasma Galectin-10 and mucosal eosinophil infiltration in chronic rhinosinusitis2019

    • Author(s)
      Yamada T, Miyabe Y, Saito H, Fujieda S, Ueki S.
    • Organizer
      15th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 耳鼻咽喉科医が対応する I 型アレルギー疾患の病態と治療-難治性中耳炎を含めて-2019

    • Author(s)
      山田武千代
    • Organizer
      令和元年関東東京耳鼻咽喉科教育研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 難治性中耳炎治療の工夫と課題 - I 型アレルギーとの関連も含めて2019

    • Author(s)
      山田武千代.
    • Organizer
      第29回日本耳科学会学術講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 慢性副鼻腔炎組織好酸球浸潤の血漿バイオマーカーの検索2019

    • Author(s)
      山田武千代
    • Organizer
      第36回耳鼻咽喉科ニューロサイエンス研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] アレルギー疾患と非鎮静性抗ヒスタミン薬2019

    • Author(s)
      山田武千代
    • Organizer
      Allergy Symposium 2019 in TOHOKU
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 鼻粘膜の局所炎症とIgEの関与2019

    • Author(s)
      山田武千代
    • Organizer
      令和元年 Allergy Navigation
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 知っておきたい気道疾患の病態と治療2019

    • Author(s)
      山田武千代
    • Organizer
      令和元年AKITA県南医学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 上気道咳嗽疾患とアレルギー2019

    • Author(s)
      山田武千代
    • Organizer
      第21回日本咳嗽学会 ポストコングレス講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 教育講演 真菌と上気道炎症性疾患2019

    • Author(s)
      山田武千代
    • Organizer
      第68回 日本アレルギー学会学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] モーニングセミナー3 抗原特異的舌下免疫療法のメカニズム-アレルギー性鼻炎のバイオマーカー2019

    • Author(s)
      山田武千代.
    • Organizer
      第58回日本鼻科学会総会・学術講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 領域講習4 専門医を悩ませる高齢疾患の対応 秋田県における老人性鼻漏のアンケート調査2019

    • Author(s)
      山田武千代
    • Organizer
      第33回日本耳鼻咽喉科学会専門医講習会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 難治性アレルギー性鼻炎の病態と治療2019

    • Author(s)
      山田武千代
    • Organizer
      令和元年青森県耳鼻咽喉科医会・臨床セミナー青森
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 耳鼻咽喉科領域難治性疾患の病態と制御2019

    • Author(s)
      山田武千代
    • Organizer
      第65回沖縄耳鼻咽喉科懇話会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] アレルギー関連疾患に対する精密医療2019

    • Author(s)
      山田武千代
    • Organizer
      第142 回徳島県耳鼻咽喉科医会研修会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] アレルギー疾患と非鎮静性抗ヒスタミン薬2019

    • Author(s)
      山田武千代
    • Organizer
      Allergy Symposium in Tohoku 2019
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 難治性アレルギー性鼻炎の病態2019

    • Author(s)
      山田武千代
    • Organizer
      大阪花粉症フォーラム2019
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 花粉症の病態と治療に関する最近の話題, ,2019

    • Author(s)
      山田武千代
    • Organizer
      2019 鼻アレルギー講演会 in 北和
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] アレルギー性鼻炎の病態と治療に関する最近の話題2019

    • Author(s)
      山田武千代
    • Organizer
      平成31年大角医会学術講演会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 難治性アレルギー性鼻炎の治療と関連疾患2019

    • Author(s)
      山田武千代
    • Organizer
      第91回郡山耳鼻咽喉科研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Identification of serum biomarker for local eosinophil infiltration in refractory rhinosinusitis.2018

    • Author(s)
      Yamada T, Saito H, Miyabe Y, Ueki S, Fujieda S, Kidoguchi M, Sakashita M
    • Organizer
      27th ERS, 37th ISIAN, 19th IRS
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The endotype of Japanese seasonal allergic rhinitis during sublingual immunotherapy.2018

    • Author(s)
      Yamada T, Saito H, Miyabe Y, Sakashita M, Ogi K, Imoto Y, Fujieda S
    • Organizer
      67th Japanese Society of Allergy,
    • Related Report
      2018 Research-status Report
  • [Presentation] 山田武千代2018

    • Author(s)
      好酸球性副鼻腔炎と好酸球性中耳炎の治療 教育セミナー3
    • Organizer
      第119回日本耳鼻咽喉科学会通常総会学術・講演会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 耳鼻咽喉科関連指定難病の注意点と課題2018

    • Author(s)
      山田武千代
    • Organizer
      第66回日本耳鼻咽喉科学会東北地方部会連合会学術講演会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 20.難治性中耳炎の病態とアレルギー・免疫関連疾患2018

    • Author(s)
      山田武千代
    • Organizer
      第28回日本耳科学会学術講演会 ランチョンセミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 耳鼻咽喉科が対応する指定難病とアレルギー性鼻炎の治療2018

    • Author(s)
      山田武千代
    • Organizer
      第119回日本耳鼻咽喉科群馬県地方部会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 鼻アレルギーの診断と治療, ,2018

    • Author(s)
      山田武千代
    • Organizer
      平成30年男鹿潟上南秋医師会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 17.気道アレルギー疾患の精密医療 -アレルギー性鼻炎を中心に-2018

    • Author(s)
      山田武千代
    • Organizer
      平成30年度耳鼻咽喉科東京夏季臨床フォーラム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 耳鼻咽喉科領域における最近の話題 -指定難病を中心に-2018

    • Author(s)
      山田武千代
    • Organizer
      千葉気道アレルギーフォーラム2018
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 耳鼻咽喉科関連指定難病とアレルギー性鼻炎2018

    • Author(s)
      山田武千代
    • Organizer
      第375回郡医研
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 頭頸部外科領域の内視鏡手術2018

    • Author(s)
      山田武千代
    • Organizer
      第83回秋田県医学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 耳鼻咽喉科関連指定難病の注意点と課題2018

    • Author(s)
      山田武千代
    • Organizer
      第97回富山県耳鼻咽喉科臨床研究会,教育講演
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Identification of serum biomarker for local eosinophil infiltration in refractory rhinosinusitis2018

    • Author(s)
      Yamada T
    • Organizer
      27th ERS
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The phenotypes of Japanese seasonal allergic rhinitis during prophylactic treatment with montelukast.2017

    • Author(s)
      Yamada T
    • Organizer
      37th ISIAN
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新たな抗ヒスタミン薬治療の幕開け-耳鼻咽喉科領域における抗ヒスタミン薬-2017

    • Author(s)
      山田武千代
    • Organizer
      第66回日本アレルギー学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 耳鼻咽喉科からみる咳嗽疾患-アレルギー性鼻炎を中心に-2017

    • Author(s)
      山田武千代
    • Organizer
      第19回日本咳嗽研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Clinical trial of neurosurgery using olfactory mucosa for severe facial palsy.2017

    • Author(s)
      Yamada T
    • Organizer
      10th Neural function recovery seminar
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 花粉症治療の未来 (Treatment for pollinosis in future)2020

    • Author(s)
      山田武千代
    • Publisher
      Pharma Medica
    • Related Report
      2020 Annual Research Report
  • [Book] COVID-19パンデミックと舌下免疫療法2020

    • Author(s)
      山田武千代
    • Publisher
      ENTONI
    • Related Report
      2020 Annual Research Report
  • [Book] アレルギー性鼻炎に対する薬物療法.2020

    • Author(s)
      山田武千代 宮部結 山田俊樹 富澤 宏基
    • Publisher
      PROGRESS IN MEDICINE
    • Related Report
      2020 Annual Research Report
  • [Book] アレルギーと自然免疫2020

    • Author(s)
      山田武千代
    • Publisher
      JOHNS
    • Related Report
      2020 Annual Research Report
  • [Book] アレルギー性鼻炎[私の治療]2020

    • Author(s)
      山田武千代
    • Publisher
      日本医事新報
    • Related Report
      2020 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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