| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
It is difficult to restore the function of olfactory neurogenic olfactory dysfunction that has resulted in loss of olfactory function. This study was conducted to establish the basis for the development of a new treatment to improve the prognosis of severe neurogenic olfactory dysfunction by combining olfactory mucosa transplantation with the promotion of olfactory nerve regeneration through inflammation control. Using genetically modified mice, the researchers created an olfactory nerve transection model and an olfactory mucosa loss model, and performed olfactory mucosa transplantation and anti-inflammatory treatment in areas of olfactory mucosa loss. As a result, viable cells were found only in some of the areas. The patients underwent olfactory testing using behavioral assessment, but this did not restore olfactory function in any of the cases. Further development of methods will be necessary if the transplanted olfactory cells are to exhibit even olfactory function.
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