Molecular imaging research for olfactory dysfunction in Parkinson's disease
| Project/Area Number |
17K11369
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Kanazawa Medical University |
|---|
Principal Investigator |
SHIGA Hideaki 金沢医科大学, 医学部, 准教授 (80436823)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
三輪 高喜 金沢医科大学, 医学部, 教授 (20229909)
|
|---|
| Project Period (FY) |
2017-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 嗅覚障害 / 分子イメージング / パーキンソン病 / 感冒 / 核医学検査 / オルファクトシンチグラフィ / 異嗅症 / タリウム / 嗅球 / ドーパミン作動性ニューロン / ロテノン / オルファクトシンチ / SPECT-CT / 予後因子 / 嗅覚刺激療法 / ミトコンドリア呼吸鎖阻害薬 |
|---|
| Outline of Final Research Achievements |
In this study, we aimed to determine whether the assessment of olfactory neuronal damage with 201Tl-based olfactory scintigraphy is useful for distinguishing patients with olfactory dysfunction due to idiopathic Parkinson's disease from those with post-upper respiratory infection hyposmia and healthy volunteers. The subjects were enrolled in this study at the smell clinic in Kanazawa Medical University Hospital. The imaging factor indicating olfactory neuronal damage, such as diffusion of nasally administered 201Tl to the olfactory bulb rate, was determined for each subject. The imaging factor was significantly reduced in all patient groups in comparison to healthy volunteers. 201Tl diffusion to the olfactory bulb rate was not significantly different between the patient groups with olfactory impairment. It needs a new analysis marker for the thallium uptake to differentiate idiopathic Parkinson's disease from post-upper respiratory infection hyposmia.
|
| Academic Significance and Societal Importance of the Research Achievements |
これまで病態が十分には明らかでなかった早期パーキンソン病の嗅覚障害において、嗅神経を画像評価可能な新規分子イメージングの「オルファクトシンチグラフィ」により、脳内への嗅神経輸送機能障害が明らかとなった。脳内への経鼻的薬物送達システムを利用したパーキンソン病に対する治療研究において、対象患者に対して嗅覚検査やオルファクトシンチグラフィを用いた嗅神経障害の有無の評価が重要であることが示唆された。オルファクトシンチグラフィは本研究グループが世界に先駆けて開発した分子イメージングであり、本邦における脳神経疾患の診断と治療に大きく貢献できると考えられる。
|
Report
(5 results)
Research Products
(62 results)
-
[Journal Article] Thallium-201 Imaging in Intact Olfactory Sensory Neurons with Reduced Pre-Synaptic Inhibition In Vivo.2020
Author(s)
Shiga H, Wakabayashi H, Washiyama K, Noguchi T, Hiromasa T, Miyazono S, Kumai M, Ogawa K, Taki J, Kinuya S, Miwa T.
-
Journal Title
Mol Neurobiol
Volume: 57
Issue: 12
Pages: 4989-4999
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
[Journal Article] Clinical practice guidelines for the management of olfactory dysfunction - Secondary publication.2019
Author(s)
Miwa T, Ikeda K, Ishibashi T, Kobayashi M, Kondo K, Matsuwaki Y, Ogawa T, Shiga H, Suzuki M, Tsuzuki K, Furuta A, Motoo Y, Fujieda S, Kurono Y.
-
Journal Title
Auris Nasus Larynx
Volume: 46
Issue: 5
Pages: 653-662
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Effects of Tokishakuyakusan on regeneration of murine olfactory neurons in vivo and in vitro.2019
Author(s)
Noda, T., Shiga, H., Yamada, K., Harita, M., Nakamura Y., Ishikura T., Kumai M., Kawakami Z., Kaneko A., Hatta T., Sakata-Haga H., Shimada H., Miwa, T.
-
Journal Title
Chemical Senses
Volume: 44
Issue: 5
Pages: 327-338
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
[Journal Article] 嗅覚検査の動向2018
Author(s)
志賀英明, 三輪高喜
-
Journal Title
Nippon Jibiinkoka Gakkai Kaiho
Volume: 121
Issue: 11
Pages: 1329-1335
DOI
NAID
ISSN
0030-6622, 1883-0854
Year and Date
2018-11-20
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Rotenone nasal exposure may increase the risk of neurodegenerative diseases via enhanced olfactory transport of metals to the olfactory bulb.2019
Author(s)
Shiga H, Wakabayashi H, Washiyama K, Noguchi T, Hiromasa T, Miyazono S, Kumai M, Ogawa K, Kashiwayanagi M, Taki J , Kinuya S, Miwa T.
Organizer
15th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
