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Molecular imaging research for olfactory dysfunction in Parkinson's disease

Research Project

Project/Area Number 17K11369
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKanazawa Medical University

Principal Investigator

SHIGA Hideaki  金沢医科大学, 医学部, 准教授 (80436823)

Co-Investigator(Kenkyū-buntansha) 三輪 高喜  金沢医科大学, 医学部, 教授 (20229909)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords嗅覚障害 / 分子イメージング / パーキンソン病 / 感冒 / 核医学検査 / オルファクトシンチグラフィ / 異嗅症 / タリウム / 嗅球 / ドーパミン作動性ニューロン / ロテノン / オルファクトシンチ / SPECT-CT / 予後因子 / 嗅覚刺激療法 / ミトコンドリア呼吸鎖阻害薬
Outline of Final Research Achievements

In this study, we aimed to determine whether the assessment of olfactory neuronal damage with 201Tl-based olfactory scintigraphy is useful for distinguishing patients with olfactory dysfunction due to idiopathic Parkinson's disease from those with post-upper respiratory infection hyposmia and healthy volunteers. The subjects were enrolled in this study at the smell clinic in Kanazawa Medical University Hospital. The imaging factor indicating olfactory neuronal damage, such as diffusion of nasally administered 201Tl to the olfactory bulb rate, was determined for each subject. The imaging factor was significantly reduced in all patient groups in comparison to healthy volunteers. 201Tl diffusion to the olfactory bulb rate was not significantly different between the patient groups with olfactory impairment. It needs a new analysis marker for the thallium uptake to differentiate idiopathic Parkinson's disease from post-upper respiratory infection hyposmia.

Academic Significance and Societal Importance of the Research Achievements

これまで病態が十分には明らかでなかった早期パーキンソン病の嗅覚障害において、嗅神経を画像評価可能な新規分子イメージングの「オルファクトシンチグラフィ」により、脳内への嗅神経輸送機能障害が明らかとなった。脳内への経鼻的薬物送達システムを利用したパーキンソン病に対する治療研究において、対象患者に対して嗅覚検査やオルファクトシンチグラフィを用いた嗅神経障害の有無の評価が重要であることが示唆された。オルファクトシンチグラフィは本研究グループが世界に先駆けて開発した分子イメージングであり、本邦における脳神経疾患の診断と治療に大きく貢献できると考えられる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (62 results)

All 2021 2020 2019 2018 2017

All Journal Article (21 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 7 results) Presentation (41 results) (of which Int'l Joint Research: 14 results,  Invited: 11 results)

  • [Journal Article] Thallium-201 Imaging in Intact Olfactory Sensory Neurons with Reduced Pre-Synaptic Inhibition In Vivo.2020

    • Author(s)
      Shiga H, Wakabayashi H, Washiyama K, Noguchi T, Hiromasa T, Miyazono S, Kumai M, Ogawa K, Taki J, Kinuya S, Miwa T.
    • Journal Title

      Mol Neurobiol

      Volume: 57 Issue: 12 Pages: 4989-4999

    • DOI

      10.1007/s12035-020-02078-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The impact of ovariectomy on olfactory neuron regeneration in mice2020

    • Author(s)
      Yamada K, Shiga H, Noda T, Harita M, Ishikura T, Nakamura Y, Hatta T, Sakata-Haga H, Shimada H, Miwa T
    • Journal Title

      Chem Senses

      Volume: 45 Issue: 3 Pages: 203-209

    • DOI

      10.1093/chemse/bjaa005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 嗅覚障害の種々相2020

    • Author(s)
      志賀英明, 三輪高喜
    • Journal Title

      MB ENT

      Volume: 251 Pages: 29-34

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 嗅覚障害に対する処置2020

    • Author(s)
      志賀英明, 三輪高喜
    • Journal Title

      JOHNS

      Volume: 36 Pages: 649-651

    • Related Report
      2020 Annual Research Report
  • [Journal Article] はなづまりと嗅覚障害2020

    • Author(s)
      志賀英明, 三輪高喜
    • Journal Title

      MB ENT

      Volume: 241 Pages: 17-22

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Relationship Between Olfactory Disturbance After Acute Ischemic Stroke and Latent Thalamic Hypoperfusion.2020

    • Author(s)
      Okamoto K, Shiga H, Nakamura H, Matsui M, Miwa T.
    • Journal Title

      Chem Senses

      Volume: 45 Issue: 2 Pages: 111-118

    • DOI

      10.1093/chemse/bjz077

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nasal thallium-201 uptake in patients with parosmia with and without hyposmia after upper respiratory tract infection.2019

    • Author(s)
      Shiga H., Okuda K., Taki J., Watanabe N., Tonami H., Kinuya S., Miwa T.
    • Journal Title

      Int Forum Allergy Rhinol

      Volume: 9 Issue: 11 Pages: 1252-1256

    • DOI

      10.1002/alr.22395

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical practice guidelines for the management of olfactory dysfunction - Secondary publication.2019

    • Author(s)
      Miwa T, Ikeda K, Ishibashi T, Kobayashi M, Kondo K, Matsuwaki Y, Ogawa T, Shiga H, Suzuki M, Tsuzuki K, Furuta A, Motoo Y, Fujieda S, Kurono Y.
    • Journal Title

      Auris Nasus Larynx

      Volume: 46 Issue: 5 Pages: 653-662

    • DOI

      10.1016/j.anl.2019.04.002

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Tokishakuyakusan on regeneration of murine olfactory neurons in vivo and in vitro.2019

    • Author(s)
      Noda, T., Shiga, H., Yamada, K., Harita, M., Nakamura Y., Ishikura T., Kumai M., Kawakami Z., Kaneko A., Hatta T., Sakata-Haga H., Shimada H., Miwa, T.
    • Journal Title

      Chemical Senses

      Volume: 44 Issue: 5 Pages: 327-338

    • DOI

      10.1093/chemse/bjz023

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of olfactory impairment with indexes of sarcopenia and frailty in community-dwelling older adults.2019

    • Author(s)
      Harita, Miwa, Shiga, Yamada, Sugiyama, Okabe, Miyake, Okuno, Iritan, Morimoto.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: Epub Issue: 5 Pages: 1-8

    • DOI

      10.1111/ggi.13621

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] パーキンソン病診断におけるオルフファクトシンチグラフィの意義2019

    • Author(s)
      志賀英明, 三輪高喜
    • Journal Title

      Precision Medicine

      Volume: 2 Pages: 85-89

    • Related Report
      2019 Research-status Report
  • [Journal Article] 嗅覚障害に対する内服・点鼻薬の使い方2019

    • Author(s)
      志賀英明, 三輪高喜
    • Journal Title

      MB ENT

      Volume: 231 Pages: 63-67

    • Related Report
      2019 Research-status Report
  • [Journal Article] 嗅覚検査の動向2018

    • Author(s)
      志賀英明, 三輪高喜
    • Journal Title

      Nippon Jibiinkoka Gakkai Kaiho

      Volume: 121 Issue: 11 Pages: 1329-1335

    • DOI

      10.3950/jibiinkoka.121.1329

    • NAID

      130007534819

    • ISSN
      0030-6622, 1883-0854
    • Year and Date
      2018-11-20
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 嗅神経性嗅覚障害の病態解明と治療への応用2018

    • Author(s)
      山田健太郎、志賀英明, 能田拓也、張田雅之、二宮英明、三輪高喜
    • Journal Title

      Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology)

      Volume: 57 Issue: 1 Pages: 83-86

    • DOI

      10.7248/jjrhi.57.83

    • NAID

      130006708699

    • ISSN
      0910-9153, 1883-7077
    • Related Report
      2018 Research-status Report
  • [Journal Article] 『わかりやすい感覚器疾患』IV. 感覚器疾患の検査法 嗅覚同定検査2018

    • Author(s)
      志賀英明
    • Journal Title

      日本医師会雑誌

      Volume: 147 Pages: 224-225

    • Related Report
      2018 Research-status Report
  • [Journal Article] パーキンソン病の末梢病変の検出 ー嗅覚研究からー2018

    • Author(s)
      志賀英明, 三輪高喜
    • Journal Title

      別冊BIO Clinica 慢性炎症と疾患

      Volume: 7 Pages: 142-144

    • Related Report
      2018 Research-status Report
  • [Journal Article] 新規分子イメージング“オルファクトシンチグラフィ”のパーキンソン病性嗅覚障害への応用2018

    • Author(s)
      志賀英明, 三輪高喜
    • Journal Title

      Medical Science Digest

      Volume: 44 Pages: 2-4

    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Journal Article] タリウム分子イメージングによる嗅神経シナプスの評価2018

    • Author(s)
      志賀英明, 三輪高喜
    • Journal Title

      細胞

      Volume: 50 Pages: 759-761

    • Related Report
      2018 Research-status Report
  • [Journal Article] Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients with idiopathic olfactory dysfunction.2017

    • Author(s)
      Shiga H, Taki J, Okuda K, Watanabe N, Tonami H, Nakagawa H, Kinuya S, Miwa T.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 3581-3581

    • DOI

      10.1038/s41598-017-03894-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 嗅覚とその障害 嗅覚障害に対する漢方治療2017

    • Author(s)
      志賀英明, 三輪高喜
    • Journal Title

      JOHNS

      Volume: 33 Pages: 231-233

    • Related Report
      2017 Research-status Report
  • [Journal Article] 嗅覚障害診療ガイドライン2017

    • Author(s)
      三輪高喜、池田勝久、小河孝夫、小林正佳、近藤健二、志賀英明、鈴木元彦、石橋卓也、都築建三、古田厚子、松脇由典、元雄良治、藤枝重治、黒野祐一
    • Journal Title

      Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology)

      Volume: 56 Issue: 4 Pages: 487-556

    • DOI

      10.7248/jjrhi.56.487

    • NAID

      130006286326

    • ISSN
      0910-9153, 1883-7077
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Development and application of olfactory scintigraphy to image olfactory sensory neurons.2021

    • Author(s)
      Shiga H, Miwa T.
    • Organizer
      The 61th Annual Congress of Korean Rhinologic Society, International session II
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 嗅神経を介した薬物送達システム2020

    • Author(s)
      志賀英明, 三輪高喜
    • Organizer
      第59回日本鼻科学会 シンポジウム1
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 嗅覚障害の診断と治療 近未来への展望2020

    • Author(s)
      志賀英明, 三輪高喜
    • Organizer
      第121回日本耳鼻咽喉科学会 教育講演
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 嗅覚障害の定義・分類・疫学2020

    • Author(s)
      志賀英明
    • Organizer
      第7回嗅覚冬のセミナー 嗅覚診療の総論
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 柏柳メモリアル2: ドーパミン作動性介在ニューロンが減少した嗅球へのタリウム嗅神経輸送2020

    • Author(s)
      志賀英明, 野口智弘, 宮園貞治, 三輪高喜
    • Organizer
      日本味と匂学会第54回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 柏柳メモリアル1: 嗅覚障害の発生機序の違いによって異なる嗅球シナプスの可塑性2020

    • Author(s)
      野口智弘, 笹島 仁, 宮園貞治, 志賀英明, 三輪高喜
    • Organizer
      日本味と匂学会第54回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Olfactory Disorders: Diagnosis and Discussion2019

    • Author(s)
      Shiga H, Miwa T.
    • Organizer
      RhinoWorld Chicago 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Nasal thallium-201 uptake in parosmia patients after upper respiratory tract infection.2019

    • Author(s)
      Shiga H, Miwa T.
    • Organizer
      RhinoWorld Chicago 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Nasal administration of adipose tissue derived stem cells in olfactory impaired mice.2019

    • Author(s)
      Shiga H, Ishikura T, Nakamura Y, Ishigaki Y, Miwa T.
    • Organizer
      RhinoWorld Chicago 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of the neuroblast in the brain with intranasal administration of IGF-1.2019

    • Author(s)
      Nakamura Y, Shiga H, Hatta T, Sakata H, Ninomiya H, Miwa T.
    • Organizer
      RhinoWorld Chicago 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] A study on the regeneration of the olfactory epithelium in ovariectomized mice.2019

    • Author(s)
      Yamada K, Shiga H, Noda T, Ninomiya H, Miwa T.
    • Organizer
      RhinoWorld Chicago 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] オルファクトシンチによる感冒後異嗅症の検討2019

    • Author(s)
      志賀英明, 三輪高喜
    • Organizer
      第120回日本耳鼻咽喉科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 経鼻的投与したIGF-1の脳内神経芽細胞遊走へ及ぼす影響2019

    • Author(s)
      中村有加里, 志賀英明, 二宮英明, 坂田ひろみ, 八田稔久, 三輪高喜
    • Organizer
      第120回日本耳鼻咽喉科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 当帰芍薬散が嗅神経の再生に及ぼす影響に関する研究2019

    • Author(s)
      能田拓也, 山田健太郎, 張田雅之, 中村有加里, 石倉友子, 熊井理美, 志賀英明, 三輪高喜
    • Organizer
      第120回日本耳鼻咽喉科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 加齢に伴う嗅覚低下の問題点と予防2019

    • Author(s)
      志賀英明, 張田雅之, 山田健太郎, 三輪高喜
    • Organizer
      第81回耳鼻咽喉科臨床学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Rotenone nasal exposure may increase the risk of neurodegenerative diseases via enhanced olfactory transport of metals to the olfactory bulb.2019

    • Author(s)
      Shiga H, Wakabayashi H, Washiyama K, Noguchi T, Hiromasa T, Miyazono S, Kumai M, Ogawa K, Kashiwayanagi M, Taki J , Kinuya S, Miwa T.
    • Organizer
      15th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical features and treatment results of the patients with olfactory disorders.2019

    • Author(s)
      Nishimae N, Shiga H, Kumai M, Ishikura T, Nakamura Y, Harita M, Yamada K, Yao T, Miwa T.
    • Organizer
      15th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 嗅上皮障害マウスにおける脂肪由来幹細胞経鼻投与の有効性2019

    • Author(s)
      石倉友子, 志賀英明, 熊井理美, 三輪高喜
    • Organizer
      第58回日本鼻科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 脳透明化による嗅覚中枢描出の検討2019

    • Author(s)
      中村有加里, 志賀英明, 坂田ひろみ, 八田稔久, 三輪高喜
    • Organizer
      第58回日本鼻科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 地域在住の高齢者におけるサルコペニアと嗅覚低下の関連性において2019

    • Author(s)
      張田雅之, 三輪高喜, 志賀英明, 山田健太郎, 杉山恵理子, 岡辺有紀, 三宅裕子, 奥野太寿生, 入谷 敦, 森本茂人
    • Organizer
      第38回日本認知症学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 経鼻的に投与したIGF-1が脳内神経芽細胞の輸送に及ぼす影響2019

    • Author(s)
      中村有加里, 志賀英明, 八田稔久, 坂田ひろみ, 二宮英明, 三輪高喜
    • Organizer
      第37回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 閉経モデルマウスにおける嗅上皮障害後の嗅上皮再生に関する研究2019

    • Author(s)
      山田健太郎, 志賀英明, 二宮英明, 三輪高喜
    • Organizer
      第37回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2019 Research-status Report
  • [Presentation] The change of nasal thallium transport with modulation of olfactory bulb interneuron.2018

    • Author(s)
      Shiga H, Washiyama K, Kumai M, Miwa T.
    • Organizer
      London Rhinology 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gender differences and influences to olfactory nerve regeneration by ovariectomy in mice.2018

    • Author(s)
      Yamada K, Kumai M, Ishikura T, Nakamura Y, Noda T, Ninomiya H, Shiga H, Miwa T.
    • Organizer
      London Rhinology 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 嗅覚検査と画像診断 国内外の動向2018

    • Author(s)
      志賀英明
    • Organizer
      第119回日本耳鼻咽喉科学会 ランチョンセミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Modulation of olfactory bulb interneurons accelerated thallium-201 migration to olfactory bulb.2018

    • Author(s)
      Shiga H, Washiyama K, Kumai M, Miwa T.
    • Organizer
      第119回日本耳鼻咽喉科学会International Session
    • Related Report
      2018 Research-status Report
  • [Presentation] 嗅神経性嗅覚障害における食事を利用した嗅覚刺激療法の比較研究2018

    • Author(s)
      志賀英明, 經田香織, 山﨑憲子, 岡本一宏, 伊崎由絵, 影近謙治, 三輪高喜
    • Organizer
      第57回日本鼻科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 閉経モデルマウスにおける嗅上皮再生障害の機序2018

    • Author(s)
      志賀英明, 山田健太郎, 能田拓也, 石倉友子, 二宮英明, 坂田ひとみ, 島田ひろき, 八田稔久, 三輪高喜
    • Organizer
      第34回日本耳鼻咽喉科漢方研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] オルファクトシンチトレーサーの嗅球移行機序2018

    • Author(s)
      志賀英明, 鷲山幸信, 若林大志, 廣正 智, 瀧 淳一, 絹谷清剛, 三輪高喜
    • Organizer
      日本味と匂学会第52回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Thallium-201 based "olfacto-scintigraphy" for traumatic smell loss patients.2017

    • Author(s)
      Shiga H, Miwa T.
    • Organizer
      Rhinology World Congress - Hong Kong 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Correlation of nasal thallium migration to olfactory bulb and olfactory bulb volume in patients with olfactory impairment after upper respiratory infection.2017

    • Author(s)
      Shiga H, Taki J, Okuda K, Watanabe N, Tonami H, Kinuya S, Miwa T
    • Organizer
      The 397h annual meeting of the Association for Chemoreception Sciences
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 鼻副鼻腔アレルギーにおける嗅覚障害2017

    • Author(s)
      志賀英明
    • Organizer
      第174回鯖江市医師会十日会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 嗅覚障害のプレシジョン・メディシン2017

    • Author(s)
      志賀英明
    • Organizer
      石川県耳鼻咽喉科医会学術講演会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 食べ方の指導による嗅覚刺激療法 鼻腔法と口腔法の比較2017

    • Author(s)
      志賀英明, 經田香織, 山﨑憲子, 岡本一宏, 伊崎由絵, 影近謙治, 三輪高喜
    • Organizer
      第118回日本耳鼻咽喉科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 感冒後嗅覚障害患者のタリウム嗅神経輸送と嗅球体積の相関2017

    • Author(s)
      志賀英明、瀧 淳一、奥田光一、渡邊直人、利波久雄、絹谷清剛、三輪高喜
    • Organizer
      第12回日本分子イメージング学会
    • Related Report
      2017 Research-status Report
  • [Presentation] オルファクトシンチによる嗅覚障害の予後診断2017

    • Author(s)
      志賀英明、瀧 淳一、奥田光一、渡邊直人、利波久雄、絹谷清剛、三輪高喜
    • Organizer
      第35回耳鼻咽喉科ニューロサイエンス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 食べ方の指導による嗅覚刺激療法 臨床試験の現況2017

    • Author(s)
      志賀英明, 經田香織, 山﨑憲子, 岡本一宏, 伊崎由絵, 影近謙治, 三輪高喜
    • Organizer
      第5回嗅覚冬のセミナー
    • Related Report
      2017 Research-status Report
  • [Presentation] オルファクトシンチグラフィ 嗅覚と分子イメージングの融合2017

    • Author(s)
      志賀英明
    • Organizer
      異分野最先端の出会い-放射性トレーサー研究の新展開
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Effects of herbal medicine on regeneration of olfactory neurons in mice2017

    • Author(s)
      Noda T, Shiga H, Yamada K, Ninomiya H, Miwa T
    • Organizer
      Rhinology World Congress - Hong Kong 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of ovariecotmy on regeneration of olfactory neuron in mice2017

    • Author(s)
      Yamada K, Shiga H, Noda T, Miwa T, Ninomiya H
    • Organizer
      Rhinology World Congress - Hong Kong 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 好酸球性副鼻腔炎手術例における嗅覚機能の長期的改善度2017

    • Author(s)
      熊井理美, 平場友子, 志賀英明, 八尾 亨, 三輪高喜
    • Organizer
      第35回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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