Genetics of chronic rhinosinusitis and related phyenotypes
| Project/Area Number |
17K11371
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 慢性副鼻腔炎 / 遺伝子多型 / GWAS / 関連解析 / メタ解析 / SNP / 症例対照関連解析 / 関連遺伝子 |
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| Outline of Final Research Achievements |
Chronic rhinosinusitis (CRS) is a complex heterogeneous disease with different phenotypes and endotypes. To improve our understanding of the pathological mechanisms underlying CRS, we performed an association study of CRS. Because of frequent assumption of an association between CRS and allergy, we chose a candidate gene approach, and focused on 52 susceptibility variants previously reported in GWAS for allergic diseases. As a result of the combined analysis using two independent case-control sample sets, we identified significant associations between CRS and six loci (5q22.1, KIF3A/IL13; 2q12, IL1RL1/IL18R1/IL18RAP; MHC region, HLA-DQA1 and MICB; 5q35, LTC4S; 9p24.1, IL33; 2p25.1, LINC00299). Although further genetic and functional analyses are needed, these findings improve our understanding of genetic factors for CRS.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性副鼻腔炎は国内外を問わず有病率の高い疾患であり、その一部には、喘息を合併するもの、難治性の好酸球性副鼻腔炎、NSAID 不耐症など重篤な症状を示し、科学的な病態解明が待たれる疾患である。より詳細な研究が必要とはなるが、本研究で同定された慢性副鼻腔炎の遺伝的要因は、慢性副鼻腔炎の病態機構のより深い理解につながり、効果的な予防法や治療法の開発に貢献することが期待できる。
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] A genetic variant near <i>TSLP</i> is associated with chronic rhinosinusitis with nasal polyps and aspirin-exacerbated respiratory disease in Japanese populations2020
Author(s)
Nakayama T, Hirota T, Asaka D, Sakashita M, Ninomiya T, Morikawa T, Okano M, Haruna S, Yoshida N, Takeno S, Tanaka Y, Yoshikawa M, Ishitoya J, Hizawa N, Isogai S, Mitsui C, Taniguchi M, Kojima H, Fujieda S, Tamari M
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Journal Title
Allergol. Int.
Volume: 69
Issue: 1
Pages: 138-140
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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[Journal Article] A cis-eQTL allele regulating reduced expression of CHI3L1 is associated with late-onset adult asthma in Japanese cohorts.2019
Author(s)
Kanazawa J, Kitazawa H, Masuko H, Yatagai Y, Sakamoto T, Kaneko Y, Iijima H, Naito T, Saito T, Noguchi E, Konno S, Nishimura M, Hirota T, Tamari M, Hizawa N
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Journal Title
BMC Medical Genetics
Volume: 20
Pages: 58-58
DOI
NAID
Related Report
Peer Reviewed / Open Access
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