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The research of regulatory T cell depletion therapy for tongue cancer

Research Project

Project/Area Number 17K11385
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKumamoto University

Principal Investigator

Orita Yorihisa  熊本大学, 大学院生命科学研究部(医), 教授 (90362970)

Co-Investigator(Kenkyū-buntansha) 三木 健太郎  岡山大学, 大学病院, 助教 (20747448)
佐藤 康晴  岡山大学, 保健学研究科, 教授 (00579831)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
KeywordsHNSCC / 4NQO / Treg / DEREGマウス / 舌癌 / 制御性T細胞 / マウス / ジフテリアトキシン
Outline of Final Research Achievements

A mouse model of 4-nitroquinoline-1-oxide (4NQO)-induced-tongue squamous cell carcinoma (SCC) was established. We found that the amount of Tregs of the experimental mice at the tumor site was over 10 times as much as control mice at the early stage of tumor progression. This time 4NQO was administered to DEREG (Depletion of regulatory T cell) mice same as the former experiments using wild-type-mice to develop tongue SCC, and diphtheria toxin was given to exclude Treg at the early stage of tumor progression. We found that further progression of the tongue SCC was blocked and the mice were free from SCC. However, it was difficult to breed DEREG mice to the number enough for statistical analysis, and moreover, some of them did not develop tongue SCC even without diphtheria toxin. We are still studying about the reasons for dispersion of the results.

Academic Significance and Societal Importance of the Research Achievements

制御性T細胞 (Treg)の浸潤は近年多くの癌種において予後不良因子として報告されており、例えば分子標的治療薬イピリムマブはTregの機能低下および腫瘍組織におけるTreg数の減少により腫瘍免疫反応を亢進させ抗腫瘍効果を狙ったものです。この治療薬を癌進行のどの時期に投薬するのが有効かわかれば、より患者の肉体的・経済的負担に見合ったカスタマイズされた治療計画の立案が可能になると思われます。また、この動物実験で観察されたように前癌病変の段階でTregを制御することによってそれ以上の進行を食い止められるのであれば、癌予防治療にもつながると考えています。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results)

  • [Journal Article] Young adult patients with squamous cell carcinoma of the tongue strongly express p16 without human papillomavirus infection2019

    • Author(s)
      Tachibana Tomoyasu、Orita Yorihisa、Gion Yuka、Miki Kentaro、Ikegami Kana、Marunaka Hidenori、Makino Takuma、Akagi Yusuke、Akisada Naoki、Tsumura Munechika、Ito Toshihiro、Yoshino Tadashi、Nishizaki Kazunori、Sato Yasuharu
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 139 Issue: 1 Pages: 80-84

    • DOI

      10.1080/00016489.2018.1541506

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] KRAS mutation in tongue squamous cell carcinoma.2019

    • Author(s)
      Akagi Y
    • Journal Title

      Acta Otolaryngol

      Volume: 139 Issue: 7 Pages: 647-651

    • DOI

      10.1080/00016489.2019.1610574

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Computed Tomography Findings for Diagnosing Follicular Thyroid Neoplasms2018

    • Author(s)
      (101)Makino T, Orita Y, Tachibana T, Marunaka H, Miki K, Akisada N, Akagi Y, Usui Y, Sato Y, Yoshino T, Nishizaki K.
    • Journal Title

      Acta Medica Okayama

      Volume: 72 Issue: 6 Pages: 577-581

    • DOI

      10.18926/AMO/56375

    • NAID

      120006545160

    • URL

      https://ousar.lib.okayama-u.ac.jp/56375

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neck metastasis in patients with T1-2 supraglottic cancer.2018

    • Author(s)
      (96)Tachibana T, Orita Y, Marunaka H, Makihara S, Hirai M, Gion Y, Ikegami K, Miki K, Makino T, Noyama Y, Komatsubara Y, Kimura M, Yoshino T, Nishizaki K, Sato Y.
    • Journal Title

      Auris Nasus Larynx

      Volume: 45 Issue: 3 Pages: 1-5

    • DOI

      10.1016/j.anl.2017.06.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Laryngeal squamous cell papilloma is highly associated with human papillomavirus.2018

    • Author(s)
      Orita Y, Gion Y, Tachibana T, Ikegami K, Marunaka H, Makihara S, Yamashita Y, Miki K, Makino T, Akisada N, Akagai Y, Kimura M, Yoshino T, Nishizaki K, Sato Y.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: - Issue: 4 Pages: 350-355

    • DOI

      10.1093/jjco/hyy009

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulatory T cells in head and neck cancer2018

    • Author(s)
      折田 頼尚
    • Journal Title

      Journal of Japan Society of Immunology & Allergology in Otolaryngology

      Volume: 36 Issue: 1 Pages: 35-39

    • DOI

      10.5648/jjiao.36.35

    • NAID

      130006619250

    • ISSN
      0913-0691, 2185-5900
    • Related Report
      2017 Research-status Report
    • Open Access

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Published: 2017-04-28   Modified: 2022-01-27  

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