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Basic and Clinical Researches regarding the effect of trehakose eyedrops on maintaining postoperative filtration blrb

Research Project

Project/Area Number 17K11416
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionHirosaki University

Principal Investigator

Metoki Tomomi  弘前大学, 医学研究科, 客員研究員 (00400169)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords緑内障 / 線維柱帯切除術 / トレハロース / 濾過胞 / 眼圧 / 線維柱帯切除手術 / 線維芽細胞 / 緑内障濾過手術 / 薬理学 / 眼科学 / 緑内障手術
Outline of Final Research Achievements

Trabeculectomy is a typical filtration surgery for glaucoma, which allows for the reduction of intraocular pressure through the formation of a filtration bleb. The success of the surgery depends on the long-term formation of filtration blebs after the surgery. In this study, I conducted a randomized, prospective, controlled study to determine whether or not trehalose eye drops after surgery can suppress postoperative fibrosis and scar formation and improve the surgical outcome. A randomized, prospective, controlled study was conducted. The results showed that there was no significant difference between the trehalose eye drop group and the control group in terms of both postoperative bleb formation and degree of intraocular pressure reduction.

Academic Significance and Societal Importance of the Research Achievements

トレハロースは眼結合組織において線維芽細胞と血管内皮細胞の増殖を抑制する。この性質を利用して、線維柱帯切除術術後濾過胞の瘢痕化が抑制できるのではないかとの発想の元に研究を行った。しかし、現在の定型的な術式であるマイトマイシンC併用線維柱帯切除術はそれ自体で術後濾過胞の瘢痕形成を抑制する効果を有しており、その状態にトレハロース点眼が相加的に作用する程の明らかな効果をきたす程ではないことが明らかとなった。また、マイトマイシンCの術後併発症である結膜の菲薄化を回避するためにはさらなる方策を検討する必要があることが明らかになった。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2017 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] N-methyl-N-nitrosourea-induced photoreceptor degeneration is inhibited by nicotinamide via the blockade of upstream events before the phosphorylation of signaling proteins.2019

    • Author(s)
      Sugano E, Tabata K, Takezawa T, Shiraiwa R, Muraoka H, Metoki T, Kudo A, Nakazawa M, Tomita H, Iwama Y
    • Journal Title

      BioMed Research International

      Volume: 2019 Pages: 1-10

    • DOI

      10.1155/2019/3238719

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ぶどう膜炎にてステロイド治療中にニューモシスチス肺炎を併発した死亡例1例を含む3症例2018

    • Author(s)
      工藤孝志、江目孝幸、田名部玲子、工藤朝香、目時友美、安達功武、鈴木幸彦、中澤 満
    • Journal Title

      臨床眼科

      Volume: 72 Pages: 775-780

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Macular edema associated with intraocular ointment after cataract surgery2018

    • Author(s)
      Kudo A, Kudo T, Takahashi D, Metoki T, Suzuki Y, Nakazawa M
    • Journal Title

      American Journal of Ophthalmology Case Reports

      Volume: 10 Pages: 152-156

    • DOI

      10.1016/j.ajoc.2018.02.027

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 術前網膜光凝固の有無による糖尿病網膜症の硝子体サイトカインと術後炎症2018

    • Author(s)
      鈴木幸彦、安達功武、工藤孝志、鈴木 香、目時友美、中澤 満
    • Organizer
      第122回日本眼科学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 内境界膜剥離操作が神経節細胞層に及ぼす影響2018

    • Author(s)
      工藤孝志、鈴木幸彦、目時友美、安達功武、毛内奈津姫、中澤 満
    • Organizer
      第122回日本眼科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 増殖糖尿病網膜症に対する汎網膜光凝固術既往の有無による硝子体サイトカイン濃度の差2017

    • Author(s)
      鈴木幸彦、安達功武、工藤孝志、鈴木 香、目時友美、中澤 満
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2017 Research-status Report
  • [Book] 強膜炎(分担執筆) 実戦メディカル眼科治療アップデート2019

    • Author(s)
      目時友美
    • Publisher
      医学書院
    • Related Report
      2019 Research-status Report
  • [Remarks] 弘前大学医学部眼科学教室・診療案内・トレハロースの眼科への応用

    • URL

      http://www.med.hirosaki-u.ac.jp/~ophthal/consult.html

    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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