Exploratory study of new lesions on fundus imaging and their molecular mechanisms in diabetic retinopathy
| Project/Area Number |
17K11423
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大音 壮太郎 京都大学, 医学研究科, 特定講師 (10511850)
鈴間 潔 香川大学, 医学部, 教授 (80335265)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖尿病網膜症 / 糖尿病黄斑浮腫 / 光干渉断層計アンギオグラフィー / 抗VEGF療法 / 自己抗体 / 視細胞障害 / 抗fumarase抗体 / 抗hexokinase 1抗体 / 眼底自発蛍光 / 眼底イメージング / 神経変性 / OCT angiography / トランスレーショナルリサーチ / 免疫学 |
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| Outline of Final Research Achievements |
We investigated lesions on novel fundus imaging devices and characterized the disturbed blood flow and corresponding neuroglial disturbance in diabetic retinopathy. We demonstrated that some of these findings are predictors of the efficacy or treatment frequency of anti-VEGF therapy for diabetic macular edema. Additionally, we focused on autoimmune mechanisms in foveal photoreceptor damages and revealed that anti-fumarase antibody, as a novel autoantibody, promotes the dropout of photoreceptor inner and outer segments.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究において、糖尿病網膜症における血管と神経の障害が相互に影響しながら進行するメカニズムの一端を明らかにした。これらの所見は非侵襲的に評価できるが、糖尿病黄斑浮腫(DME)治療による視力改善や治療回数などの予測に有用な因子も見出した。つまり、これらの所見はDME患者の診療の質を向上し、治療最適化に大きく貢献した。また、イメージング所見が示唆していたunmet medical needsである視細胞障害がある。本研究ではそのメカニズムとして新規自己抗体による視細胞脱落を見出し、新規治療標的を明らかにした。
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema following Central Retinal Vein Occlusion: 1 Initial Injection versus 3 Monthly Injections.2018
Author(s)
Osaka R, Muraoka Y, Miwa Y, Manabe K, Kobayashi M, Takasago Y, Ooto S, Murakami T, Suzuma K, Iida Y, Tsujikawa A.
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Journal Title
Ophthalmologica
Volume: 239
Issue: 1
Pages: 27-35
DOI
Related Report
Peer Reviewed
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[Journal Article] ASSOCIATIONS BETWEEN MACULAR EDEMA AND CIRCULATORY STATUS IN EYES WITH RETINAL VEIN OCCLUSION: An Adaptive Optics Scanning Laser Ophthalmoscopy Study.2017
Author(s)
Iida Y, Muraoka Y, Uji A, Ooto S, Murakami T, Suzuma K, Tsujikawa A, Arichika S, Takahashi A, Miwa Y, Yoshimura N.
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Journal Title
Retina
Volume: 印刷中
Issue: 10
Pages: 1896-1904
DOI
Related Report
Peer Reviewed
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