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The mechanism of age-related macular degeneration by measuring intraocular complement factors and related proteins

Research Project

Project/Area Number 17K11427
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionFukushima Medical University

Principal Investigator

Tetsuju Sekiryu  福島県立医科大学, 医学部, 教授 (00216540)

Co-Investigator(Kenkyū-buntansha) 関根 英治  福島県立医科大学, 医学部, 教授 (40363759)
大口 泰治  福島県立医科大学, 医学部, 助教 (90595331)
小島 彰  福島県立医科大学, 医学部, 助教 (30528237)
菅野 幸紀  福島県立医科大学, 医学部, 助教 (40644828)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords滲出型加齢黄斑変性 / 補体 / アナフィラトキシン / サイトカイン / VEGF / MCP-1 / Pachychoroid / 加齢黄斑変性 / 特発性黄斑上膜 / 特発性黄斑円孔
Outline of Final Research Achievements

To investigate the effect of intraocular complement factors on angiogenic cytokines in neovascular age-related macular degeneration, we measured anaphylatoxin (C3a, C4a, C5a) concentrations and VEGF, MCP-1 in the aqueous humor.
In neovascular age-related macular degeneration, the concentration of C3a, VEGF, and MCP-1 elevated. The concentration of C3a highly correlated to that of the MCP-1. In contrast, the correlation between the VEGF level and C3a level was low in patchychoroid neovasculopathy. The pathophysiology of pachychoroid neovasculopathy, which is characterized by choroidal thickening, may be different from that of typical neovascular age-related macular degeneration, which is characterized by soft drusen.

Academic Significance and Societal Importance of the Research Achievements

滲出型加齢黄斑変性における脈絡膜新生血管の形成には補体因子が関与していることが指摘されていた。今回の研究で、脈絡膜新生血管が補体因子を介さない発症機序で形成されることを前房内蛋白を解析することで生物学的に解明することができた。今後は、従来と異なる脈絡膜新生血管機序を明らかにすることで、新たな滲出型加齢黄斑変性の治療法の開発に結びつけることができると考えている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Anaphylatoxin Concentration in Aqueous and Vitreous Humor in the Eyes With Vitreoretinal Interface Abnormalities2020

    • Author(s)
      Yasuharu Oguchi , Tetsuju Sekiryu , Tomoko Omori , Yutaka Kato , Masashi Ogasawara , Yukinori Sugano , Kanako Itagaki , Akira Ojima , Takeshi Machida , Hideharu Sekine
    • Journal Title

      Exp Eye Res

      Volume: 195 Pages: 108025-108025

    • DOI

      10.1016/j.exer.2020.108025

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for Activation of Lectin and Classical Pathway Complement Components in Aqueous Humor of Neovascular Age-Related Macular Degeneration.2020

    • Author(s)
      Omori T, Oguchi Y, Machida T, Kato Y, Ishida Y, Ojima A, Itagaki K, Shintake H, Tomita R, Kasai A, Sugano
    • Journal Title

      Ophthalmic Res

      Volume: 63 Issue: 3 Pages: 252-258

    • DOI

      10.1159/000503258

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 弱視治療年齢の調節麻痺下屈折値を眼軸長と角膜曲率半径から求める推測式2019

    • Author(s)
      森隆史,松野希望,比金真菜,笠井彩香,新田美和,橋本禎子,八子恵子,石龍鉄樹
    • Journal Title

      臨床眼科紀要

      Volume: 12 Pages: 2-2

    • Related Report
      2018 Research-status Report
  • [Journal Article] Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography.2018

    • Author(s)
      Sugano Y, Sekiryu T, Furuta M, Tomita R, Shintake H, Maehara H, Ojima A.
    • Journal Title

      Clin Ophthalmol

      Volume: 5 Pages: 12-12

    • DOI

      10.2147/opth.s179634

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Near-infrared and short-wave autofluorescence in ocular specimens.2018

    • Author(s)
      Oguchi Y, Sekiryu T, Takasumi M, Hashimoto Y, Furuta M.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 62 Issue: 5 Pages: 5-5

    • DOI

      10.1007/s10384-018-0614-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic factors after aflibercept therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy.2018

    • Author(s)
      Ogasawara M, Koizumi H, Yamamoto A, Itagaki K, Saito M, Maruko I, Okada AA, Iida T, Sekiryu T.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 62 Issue: 5 Pages: 5-5

    • DOI

      10.1007/s10384-018-0605-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 加齢黄斑変性のVEGF阻害薬治療前後でのanaphylatoxin濃度2020

    • Author(s)
      大口泰治
    • Organizer
      第124回日本眼科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Complement activation product levels in aqueous humor of patients with age-related macular degeneration2019

    • Author(s)
      加藤寛
    • Organizer
      ARVO2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 硝子体界面症候群の 眼内アナフィラトキシン濃度2019

    • Author(s)
      大口泰治
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ポリープ状脈絡膜血管症における脈絡膜厚と前房内アナフィラトキシン濃度2019

    • Author(s)
      加藤寛
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 滲出型加齢黄斑変性患者の前房水中における補体因子とサイトカインの関係2019

    • Author(s)
      加藤寛
    • Organizer
      第58回日本網膜硝子体学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 滲出型加齢黄斑変性の前房水中補体分解産物の検討.2018

    • Author(s)
      加藤寛.
    • Organizer
      第38回日本眼薬理学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 前房水中および硝子体中の補体活性化産物濃度.2018

    • Author(s)
      大口泰治
    • Organizer
      第72回日本臨床眼科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Six-month result of anti-VEGF therapy with or without laser for macular edema secondary to branch retinal vein occlusion.2018

    • Author(s)
      Yutaka Kato
    • Organizer
      ARVO 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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