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Anti-VEGF treatment for severe retinopathy of prematurity

Research Project

Project/Area Number 17K11440
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKindai University

Principal Investigator

KUSAKA Shunji  近畿大学, 医学部, 教授 (60260387)

Co-Investigator(Kenkyū-buntansha) 國吉 一樹  近畿大学, 医学部, 講師 (30234470)
杉岡 孝二  近畿大学, 大学病院, 准教授 (50399119)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords未熟児網膜症 / 血管内皮増殖因子 / 抗VEGF治療 / VEGF / 網膜光凝固 / 低出生体重児 / ranibizumab / bevacizumab / サイトカイン / 再燃 / 新生血管 / 硝子体
Outline of Final Research Achievements

Anti-vascular endothelial growth factor (VEGF) therapy was performed for infants with severe retinopathy of prematurity (ROP). Reactivation was observed in 20.9% of 43 eyes of 22 infants after ranibizumab injection and 13.5% of 37 eyes of 21 infants after bevacizumab injection(P=0.556). Multivariate logistic regression analyses revealed that anti-VEGF therapy at 35 weeks or younger post-conceptional age (OR, 7.524; 95% CI, 1.494–37.89; p = 0.014) and aggressive posterior ROP (OR, 5.532; 95% CI, 1.049–29.17; p = 0.044) were the significant risk factors for reactivation.

Academic Significance and Societal Importance of the Research Achievements

未熟児網膜症は小児失明原因の第一位を占める重要な疾患である。治療法として従来から網膜光凝固が行われてきたが、治療後の近視化、視野狭窄などの欠点があった。これに対し、近年、これらの欠点がない薬物療法(抗VEGF治療)が薬剤の適応外使用として登場した。また、2019年11月に抗VEGF治療薬であるranibizumabが未熟児網膜症の治療薬として承認された。本研究は承認前の段階からranibizumab, それ以前に使用されていたbevacizumabの治療成績や再燃因子を多数例で詳細に検討したもので今後の抗VEGF治療の普及に際して参考となる価値の高い成果であると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (13 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Early vitrectomy to reverse macular dragging in a one-month-old boy with familial exudative vitreoretinopathy.2019

    • Author(s)
      Iwata A, Kusaka S, Ishimaru M, Kondo H, Kuniyoshi K.
    • Journal Title

      Am J Ophthalmol Case Rep

      Volume: 15 Pages: 10041-10041

    • DOI

      10.1016/j.ajoc.2019.100493

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Stage 4A未熟児網膜症に対する硝子体手術後再手術例の検討2019

    • Author(s)
      歌村 翔子, 国吉 一樹, 立花 都子, 日下 俊次
    • Organizer
      第58回日本網膜硝子体学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 〔シンポジウム〕未熟児網膜症診断・治療の最前線:外科的治療2019

    • Author(s)
      日下 俊次
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Vitrectomy and/or Anti-VEGF for ROP2019

    • Author(s)
      Shunji Kusaka
    • Organizer
      19th Euretina Congres
    • Related Report
      2019 Annual Research Report
  • [Presentation] Pediatric Retina2019

    • Author(s)
      Shunji Kusaka, Mohamed Mahgoub Mogazhi, Antonio Ciardelli, Mohamed Mahgoub Mogazhi, Antonio Ciardelli,Zuhal Ozen Tunay
    • Organizer
      Mediterranean retina MeetingⅧ
    • Related Report
      2019 Annual Research Report
  • [Presentation] 〔特別講演〕難治性網膜疾患に対する治療2019

    • Author(s)
      日下 俊次
    • Organizer
      Advance in Pediatric Retina Course
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 〔特別講演〕未熟児網膜症の診断と治療2019

    • Author(s)
      日下 俊次
    • Organizer
      第8回大阪西部眼科病診連携の会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 〔特別講演〕小児に対する白内障・硝子体手術2019

    • Author(s)
      日下 俊次
    • Organizer
      第429回大阪眼科集談会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 網膜疾患-最近の話題-2019

    • Author(s)
      日下 俊次
    • Organizer
      大阪府医師会医学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Pediatric Retinal Diseases2019

    • Author(s)
      Shunji Kusaka
    • Organizer
      Asia-Pacific Academy of Ophthalmology
    • Related Report
      2019 Annual Research Report
  • [Presentation] Intravitreal ranibizumab:serum VEGF concentration change and recurrence rate(as compared with bevacizumab)2018

    • Author(s)
      Shunji Kusaka
    • Organizer
      Vietnam ROP Workshop
    • Related Report
      2018 Research-status Report
  • [Presentation] Intravitreal ranibizumab: serum VEGF concentration change and recurrence rate (as compared with bevacizumab)2018

    • Author(s)
      Shunji Kusaka
    • Organizer
      Vietnam ROP Workshop
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surgical Intervention in ROP: Indications and Outcomes2017

    • Author(s)
      Shunji Kusaka
    • Organizer
      The 11th APVRS/Congress of APVRS 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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