| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
It has been reported that Schlemm's canal, which drains the anterior chamber fluid, which is a body fluid in the eye, has a function similar to that of lymphatic vessels. The purpose of this study was to clarify whether this lymphatic vessel function is regulated and it leads to a decrease in intraocular pressure. Our previous studies have shown that macrophages are strongly involved in lymphangiogenesis. We used mice with altered macrophage function to examine whether macrophage function affects lymphangiogenesis and ocular hypotension. As a result, it was revealed that changes in macrophage function are important for lymphangiogenesis. However, it was not possible to determine whether this change would affect Schlemm's canal.
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