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Development of therapeutic drugs targeting VGF-modifying peptides in retinal diseases

Research Project

Project/Area Number 17K11486
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionGifu Pharmaceutical University

Principal Investigator

Shimazawa Masamitsu  岐阜薬科大学, 薬学部, 准教授 (80381721)

Co-Investigator(Kenkyū-buntansha) 原 英彰  岐阜薬科大学, 薬学部, 教授 (20381717)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords網膜神経節細胞 / 緑内障 / 小胞体ストレス / 神経科学 / 薬理学
Outline of Final Research Achievements

In this study, to clarify the effects of VGF nerve growth factor inducible (VGF), a secreted neuropeptide, on retinal ganglion cells, we examined the effects of VGF peptides using mouse optic nerve crush model and cultured rat retinal ganglion cells. As a result, we found that AQEE30 has 1) a protective effect on retinal ganglion cell death after optic nerve crush in mice, and 2) promoting effects on survival of retinal ganglion cells and neurite outgrowth in rat cultured retinal ganglion cells. In addition, known and novel shorter VGF-derived peptides were investigated, and some VGF-derived peptides were more effective in promoting neurite outgrowth than a combination of brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF).

Academic Significance and Societal Importance of the Research Achievements

新規VGFペプチドが緑内障をはじめとした網膜疾患治療薬として応用することを目的としている。これらの課題を解決することにより、直接的に網膜神経細胞を保護するような治療薬のない本領域において全く新しい画期的な治療法の開発に繋げることができるかもしれない。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush2018

    • Author(s)
      Takeuchi Hiroto、Inagaki Satoshi、Morozumi Wataru、Nakano Yukimichi、Inoue Yuki、Kuse Yoshiki、Mizoguchi Takahiro、Nakamura Shinsuke、Funato Michinori、Kaneko Hideo、Hara Hideaki、Shimazawa Masamitsu
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 16443-16443

    • DOI

      10.1038/s41598-018-34585-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The effect of VGF nerve growth factor inducible on retinal ganglion cell injury after optic nerve crush in mice.2018

    • Author(s)
      Masamitsu Shimazawa
    • Organizer
      ARVO 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 緑内障患者iPS細胞より分化誘導した網膜細胞を利用した緑内障の病態解明2018

    • Author(s)
      嶋澤 雅光
    • Organizer
      第91回日本生化学大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 緑内障の神経保護治療への研究アプローチ2017

    • Author(s)
      嶋澤雅光
    • Organizer
      第37回日本眼薬理学会
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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