| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Oxidative stress is a major factor in the development of various ocular diseases. Nuclear factor erythroid 2 related factor 2 (Nrf2) is known to be a key transcription factor in the regulation of multiple anti-oxidants including hemeoxygenase-1 (HO-1) and nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NADH/NADPH) quinine oxidoreductase 1 (NQO1). In the current study, we investigated the effect of Nrf2 on the development of EAU using Nrf2 knock out (KO) mouse. Pathological analysis of ocular lesion from Nrf2 KO mice with EAU revealed more severe infiltration of inflammatory cells into vitreous/retina and retinal tissue damages compared to that from wild type mice. Pathological score of EAU was higher in Nrf2 KO mice than wild type mice, although there was no significant difference between Nrf2 KO mice and wild type mice. Further study is required to determine the association between oxidative stress and the pathogenesis of autoimmune uveoretinitis.
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