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Preclinical antitumor efficacy of MEK inhibitor against neuroblastoma

Research Project

Project/Area Number 17K11517
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatric surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Higashi Mayumi  京都府立医科大学, 医学(系)研究科(研究院), 助教 (10380453)

Co-Investigator(Kenkyū-buntansha) 文野 誠久  京都府立医科大学, 医学(系)研究科(研究院), 助教 (40405254)
田尻 達郎  京都府立医科大学, 医学(系)研究科(研究院), 教授 (80304806)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経芽腫 / MEK阻害剤 / 小児腫瘍学
Outline of Final Research Achievements

In short-term observation, MEK inhibitors (trametinib or CH5126766) showed significant anti-tumor effects on pERK-positive neuroblastomas in vivo model. Neither MEK inhibitors showed anti tumor effects on pERK-negative neuroblastomas. Tumors obtained tolerance to MEK inhibitors and showed regrowth in long-term administration of drugs. (Takeuchi J Pediatr Surg. 2018 Dec;53(12):2454-2459.).
In the analyses of clinical neuroblastoma cases, some tumors showed pERK positive after chemotherapy or recurrence by immunohistochemistry. This result indicates that immunohistological analysis of pERK is useful for determination of MEK inhibitor administration.

Academic Significance and Societal Importance of the Research Achievements

神経芽腫におけるRas-ERK経路阻害による抗腫瘍効果解析の報告はほとんど無く、新規の治療ターゲットとして期待される。MEK阻害剤は既に成人癌領域にて臨床で使用されており効果が認められているものであり、小児への応用が行いやすい。難治性神経芽腫において、再発症例は既存の治療薬のみでは予後の改善が望めず、新規治療薬が求められる。MEK阻害剤は、腫瘍において優位である特異的なシグナル伝達経路を標的とすることから、従来の治療に抵抗性である腫瘍にも効果を示す可能性がある。本研究の結果から、抗腫瘍効果が期待できる腫瘍の同定が可能であると考えられるが、長期投与時の治療抵抗性の獲得も課題として認められた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (54 results)

All 2019 2018 2017

All Journal Article (22 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 18 results,  Open Access: 12 results) Presentation (27 results) (of which Int'l Joint Research: 11 results,  Invited: 1 results) Book (5 results)

  • [Journal Article] 【新生児外科疾患の精神・身体発育】仙尾部奇形腫術後の身体発育に関する長期予後2019

    • Author(s)
      文野誠久,宗崎良太,田口智章,田尻達郎
    • Journal Title

      小児外科

      Volume: 51 Pages: 86-89

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 小児がんに対する吸収性スペーサー留置を併用した粒子線治療2019

    • Author(s)
      佐々木良平,出水祐介,岩田宏満,亀井美智,文野誠久,赤坂浩亮,王 天延,妹尾悟史,犬伏祥子,宮脇大輔,吉田賢史,小松昇平,福本 巧
    • Journal Title

      The Japanese Journal of Pediatric Hematology / Oncology

      Volume: 56 Issue: 2 Pages: 148-152

    • DOI

      10.11412/jspho.56.148

    • NAID

      130007705336

    • ISSN
      2187-011X, 2189-5384
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 低位鎖肛-外来フォローにおける診察の要点2019

    • Author(s)
      文野誠久,福永健治,青井重善,田尻達郎
    • Journal Title

      小児外科

      Volume: 51 Pages: 688-691

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 【そこが知りたいシリーズ:手術で必要な局所解剖(頭頸部・胸部編)】前縦隔腫瘍摘出(奇形腫・胸腺腫瘍)2019

    • Author(s)
      文野誠久,田尻達郎
    • Journal Title

      小児外科

      Volume: 51 Pages: 795-798

    • Related Report
      2019 Annual Research Report
  • [Journal Article] The roles played by the MYCN, Trk, and ALK genes in neuroblastoma and neural development2019

    • Author(s)
      Higashi M, Sakai K, Fumino S, Aoi S, Furukawa T, Tajiri T
    • Journal Title

      Surgery Today

      Volume: 49 Issue: 9 Pages: 721-727

    • DOI

      10.1007/s00595-019-01790-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【陽子線時代の小児がんに対するQOLを重視した放射線治療における工夫】小児がん放射線治療における外科的支持療法としての性腺移動術2019

    • Author(s)
      文野誠久
    • Journal Title

      京都府立医科大学雑誌

      Volume: 128 Pages: 899-906

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Mesenchymal hamartoma of the chest wall in a 10-year-old girl mimicking malignancy: a case report2019

    • Author(s)
      Tanaka T, Fumino S, Shirai T, Konishi E, Tajiri T
    • Journal Title

      Skeletal Radiol

      Volume: 48 Issue: 4 Pages: 643-647

    • DOI

      10.1007/s00256-018-3106-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations in the RAS pathway as potential precision medicine targets in treatment of rhabdomyosarcoma.2019

    • Author(s)
      Nakagawa N, Kikuchi K, Yagyu S, Miyachi M, Iehara T, Tajiri T, Sakai T, Hosoi H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 512 Issue: 3 Pages: 524-530

    • DOI

      10.1016/j.bbrc.2019.03.038

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Japanese Clinical Practice Guidelines for Sacrococcygeal Teratoma, 20172019

    • Author(s)
      Fumino S, Tajiri T, Usui N, Tamura M, Sago H, Ono S, Nosaka S, Yoneda A, Souzaki R, Higashi M, Sakai K, Takahashi K, Sugiura T, Taguchi T
    • Journal Title

      Pediatrics International

      Volume: 61 Issue: 7 Pages: 672-678

    • DOI

      10.1111/ped.13844

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety of sirolimus treatment for intractable lymphatic anomalies: A study protocol for an open-label, single-arm, multicenter, prospective study (SILA).2019

    • Author(s)
      Ozeki M, Asada R, Saito AM, Hashimoto H, Fujimura T, Kuroda T, Ueno S, Watanabe S, Nosaka S, Miyasaka M, Umezawa A, Matsuoka K, Maekawa T, Yamada Y, Fujino A, Hirakawa S, Furukawa T, Tajiri T, Kinoshita Y, Souzaki R, Fukao T
    • Journal Title

      Regen Ther.

      Volume: 14 Pages: 84-91

    • DOI

      10.1016/j.reth.2018.12.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Results of a prospective clinical trial JN-L-10 using image-defined risk factors to inform surgical decisions for children with low-risk neuroblastoma disease: A report from the Japan Children’s Cancer Group Neuroblastoma Committee2019

    • Author(s)
      Iehara T, Yoneda A, Yokota I, Takahashi H, Teramukai S, Kamijyo T, Nakazawa A, Takimoto T, Kikuta A, Yagyu S, Ikeda H, Nakagawara A, Tajiri T
    • Journal Title

      Pediatr Blood Cancer

      Volume: 66 Issue: 11 Pages: 1-7

    • DOI

      10.1002/pbc.27914

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Novel mesenchymal stem cell delivery system as targeted therapy against neuroblastoma using the TH-MYCN mouse model2019

    • Author(s)
      Maniwa J, Fumino S, Kimura K, Tanaka T, Higashi M, Kishida T, Mazda O, Tajiri T
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 54 Issue: 12 Pages: 2600-2605

    • DOI

      10.1016/j.jpedsurg.2019.08.023

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An intra-amniotic injection of mesenchymal stem cells promotes lung maturity in a rat congenital diaphragmatic hernia model2019

    • Author(s)
      Takayama S, Sakai K, Fumino S, Furukawa T, Kishida T, Mazda O, Tajiri T
    • Journal Title

      Pediatric Surgery International

      Volume: 35 Issue: 12 Pages: 1353-1361

    • DOI

      10.1007/s00383-019-04561-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced metastatic growth after local tumor resection in the presence of synchronous metastasis in a mouse allograft model of neuroblastoma2019

    • Author(s)
      Inoue M, Tsuchiya Y, Koike N, Umemura Y, Inokawa H, Togashi Y, Maniwa J, Higashi M, Fumino S, Tajiri T, Yagita K
    • Journal Title

      Pediatric Surgery International

      Volume: 35 Issue: 12 Pages: 1403-1411

    • DOI

      10.1007/s00383-019-04568-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Derivation of neural stem cells from human teratomas2019

    • Author(s)
      Kim K, Higashi M, Fumino S, Tajiri T
    • Journal Title

      Stem Cell Research

      Volume: 41 Pages: 101633-101633

    • DOI

      10.1016/j.scr.2019.101633

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunologic Effects of Sirolimus in Patients With Vascular Anomalies.2019

    • Author(s)
      Nozawa Akifumi、Ozeki Michio、Yasue Shiho、Endo Saori、Kawamoto Norio、Ohnishi Hidenori、Fumino Shigehisa、Furukawa Taizo、Tajiri Tatsuro、Maekawa Takanobu、Fujino Akihiro、Souzaki Ryota、Fukao Toshiyuki
    • Journal Title

      Journal of Pediatric Hematology/Oncology

      Volume: e-pub Issue: 5 Pages: 1-1

    • DOI

      10.1097/mph.0000000000001650

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sequential actions of immune effector cells induced by viral activation of dendritic cells to eliminate murine neuroblastoma.2018

    • Author(s)
      Kawakubo N, Tanaka S, Kinoshita Y, Tajiri T, Yonemitsu Y, Taguchi T
    • Journal Title

      J Pediatr Surg Case Rep

      Volume: 53 Issue: 8 Pages: 1615-1620

    • DOI

      10.1016/j.jpedsurg.2017.08.019

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Results of a phase II trial for high-risk neuroblastoma treatment protocol JN-H-07: a report from the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG)2018

    • Author(s)
      Hishiki T、For the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG)、Matsumoto K、Ohira M、Kamijo T、Shichino H、Kuroda T、Yoneda A、Soejima T、Nakazawa A、Takimoto T、Yokota I、Teramukai S、Takahashi H、Fukushima T、Kaneko T、Hara J、Kaneko M、Ikeda H、Tajiri T、Nakagawara A
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 23 Issue: 5 Pages: 965-973

    • DOI

      10.1007/s10147-018-1281-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Natural antibody against neuroblastoma of TH-MYCN transgenic mice does not correlate with spontaneous regression.2018

    • Author(s)
      Kawakubo N, Harada Y, Ishii M, Souzaki R, Kinoshita Y, Tajiri T, Taguchi T, Yonemitsu Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 3 Pages: 1666-1673

    • DOI

      10.1016/j.bbrc.2018.07.097

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In vivo effects of short-and long-term MAPK pathway inhibition against neuroblastoma.2018

    • Author(s)
      Takeuchi T, Tanaka T, Higashi M, Fumino S, Iehara T, Hosoi H, Sakai T, Tajiri T
    • Journal Title

      J Pediatr Surg

      Volume: 53 Issue: 12 Pages: 2454-2459

    • DOI

      10.1016/j.jpedsurg.2018.08.026

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Advanced surgical strategy for giant mediastinal germ cell tumor in children.2017

    • Author(s)
      Fumino S, Sakai K, Higashi M, Aoi S, Furukawa T, Yamagishi M, Inoue M, Iehara T, Hosoi H, Tajiri T
    • Journal Title

      J Pediatr Surg Case Rep

      Volume: 27 Pages: 51-55

    • DOI

      10.1016/j.epsc.2017.09.023

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laparoscopic intraperitoneal onlay mesh for pediatric incisional hernia - a case report.2017

    • Author(s)
      Inoue M, Aoi S, Taniguchi A, Sakai K, Higashi M, Fumino S, Furukawa T, Tajiri T
    • Journal Title

      Surg Case Rep

      Volume: 3 Issue: 1 Pages: 122-122

    • DOI

      10.1186/s40792-017-0400-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Novel mesenchymal stem cell delivery system as targeted therapy against neuroblastoma using the TH-MYCN mouse model2019

    • Author(s)
      Maniwa J, Fumino S, Kimura K, Tanaka T, Higashi M, Kishida T, Mazda O, Tajiri T
    • Organizer
      52nd Pacific Association of Pediatric Surgeons (PAPS)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regeneration of mouse abdominal wall defects using engineered myoblasts with a biosheet2019

    • Author(s)
      Fumino S, Wakao J, Maniwa J, Sakai K, Higashi M, Aoi S, Furukawa T, Kishida T, Mazda O, Tajiri T
    • Organizer
      32nd International Symposium on Paediatric Surgical Research (ISPSR)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of fetal cell therapy using the intra-amniotic injection of mesenchymal stem cells in rat nitrofen model of congenital diaphragmatic hernia2019

    • Author(s)
      Takayama S, Furukawa T, Sakai K, Higashi M, Fumino S, Aoi S, Kishida T, Mazda O, Tajiri T
    • Organizer
      32nd International Symposium on Paediatric Surgical Research (ISPSR)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enhanced metastatic growth after local tumor resection under residual metastasis in a neuroblastoma murine model2019

    • Author(s)
      Inoue M, Tsuchiya Y, Koike N, Umemura Y, Inokawa H, Togashi Y, Maniwa J, Higashi M, Fumino S, Yagita K & Tajiri T
    • Organizer
      32nd International Symposium on Paediatric Surgical Research (ISPSR)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Post-chemotherapeutic phosphorylated-ERK immunohistochemical staining may predict the prognosis of neuroblastoma2019

    • Author(s)
      Tanaka T, Takeuchi Y, Higashi M, Fumino S, Iehara T, Hosoi H, Sakai T, Tajiri T
    • Organizer
      32nd International Symposium on Paediatric Surgical Research (ISPSR)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Current Surgical Strategy of Neuroblastoma2019

    • Author(s)
      Tajiri T
    • Organizer
      32nd International Symposium on Paediatric Surgical Research (ISPSR)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regeneration of mouse abdominal wall defects using engineered myoblasts with a biosheet; a preliminary report2019

    • Author(s)
      Fumino H, Wakao J, aniwaJ, Sakai K, Higashi M, Aoi S, Furukawa F, Kishida T, Mazda O, Tajiri T
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 外科的oncologic emergencyにおける小児外科医の役割2019

    • Author(s)
      文野誠久,坂井宏平,東 真弓,青井重善,古川泰三,青井重善,家原知子,細井 創,田尻達郎
    • Organizer
      第56回日本小児外科学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] AYA世代がん患者に対する外科的支持療法2019

    • Author(s)
      文野誠久,古川泰三,宮地 充,家原知子,細井 創,沖村浩之,森 泰輔,北脇 城,佐々木良平,田尻達郎
    • Organizer
      第57回日本癌治療学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経芽腫発症モデルマウスにおける悪性度に寄与する分子メカニズム解明にむけた研究2019

    • Author(s)
      井上真帆,土谷佳樹,池田亮介,小野龍太郎,笹脇ゆふ,坂井宏平,東 真弓,文野誠久,青井重善,古川泰三,梅村康浩,小池宣也,井之川仁,田尻達郎,八木田和弘
    • Organizer
      第14回環境生理プレコングレス
    • Related Report
      2019 Annual Research Report
  • [Presentation] 先天性横隔膜ヘルニアに対する間葉系幹細胞羊水腔投与による胎児治療開発2019

    • Author(s)
      高山勝平,坂井宏平,東 真弓,文野誠久,青井重善,古川泰三,岸田綱郎,松田 修,田尻達郎
    • Organizer
      第56回日本小児外科学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経芽腫治療における同種間葉系幹細胞による腫瘍選択的ドラッグデリバリーシステム2019

    • Author(s)
      馬庭淳之介,木村幸積,文野誠久,東 真弓,坂井宏平,青井重善,古川泰三,岸田綱郎,松田 修,田尻達郎
    • Organizer
      第56回日本小児外科学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラット胎仔横隔膜ヘルニアモデルにおける間葉系幹細胞子宮内投与による治療効果2019

    • Author(s)
      高山勝平,文野誠久,古川泰三,田尻達郎
    • Organizer
      第55回日本周産期・新生児医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経芽腫マウスにおける神経芽腫選択的な新規間葉系幹細胞デリバリーシステム2019

    • Author(s)
      Maniwa J, Fimino S, Kimura K, Tanaka T, Higashi M, Sakai K, Aoi S, Furukawa T, Kishida T, Mazda O, Tajiri T
    • Organizer
      第57回日本癌治療学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 小児腫瘍性疾患に対するナビゲーション手術の経験2019

    • Author(s)
      文野誠久,古川泰三,青井重善,東 真弓,坂井宏平,田中智子,田尻達郎
    • Organizer
      第61回日本小児血液・がん学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経芽腫再発・転移(RM)マウスモデルを用いた MEK 阻害剤の治療効果の検討2019

    • Author(s)
      Togashi Y, Takemoto M, Takeuchi Y, Tanaka T, Higashi M, Fumino S, Tajiri T
    • Organizer
      第61回日本小児血液・がん学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経芽腫転移マウスモデルにおける原発巣局所切除による残存遠隔転移巣への影響についての検討2019

    • Author(s)
      井上真帆,土谷佳樹,小池宣也,梅村康浩,井之川仁,富樫佑一,馬庭淳之介,文野誠久,東 真弓,田尻達郎,八木田和弘
    • Organizer
      第61回日本小児血液・がん学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経芽腫に対するMEK阻害剤臨床応用へ向けた臨床検体のリン酸化ERK免疫染色解析.2018

    • Author(s)
      竹内雄毅,田中智子,東 真弓,文野誠久,家原知子,細井 創,酒井敏行,田尻達郎
    • Organizer
      第51回制癌剤適応研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 臨床応用に向けた神経芽腫 xenograft に対する MEK 阻害剤前臨床試験.2018

    • Author(s)
      竹内雄毅,田中智子,東 真弓,文野誠久,家原知子,細井 創,酒井敏行,田尻達郎
    • Organizer
      第55回日本小児外科学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] MEK阻害剤感受性神経芽腫を予測するリン酸化ERK免疫組織化学の臨床応用へ向けた検討.2018

    • Author(s)
      竹内雄毅,田中智子,東 真弓,文野誠久,家原知子,細井 創,酒井敏行,田尻達郎
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] MEK阻害剤の至適投与時期検討を目的とした神経芽腫MRDモデルの確立.2018

    • Author(s)
      Togashi Y, Takeuchi Y, Higashi M, Fumino S, Tajiri T
    • Organizer
      第60回日本小児血液・がん学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 神経芽腫モデルマウスに対するマウス由来間葉系幹細胞を用いたdrug delivery systemの開発.2018

    • Author(s)
      Maniwa J, Kimura K, Fumino S, Tanaka T, Higashi M, Sakai K, Aoi S, Furukawa T, Kishida T, Mazda O, Tajiri T
    • Organizer
      第60回日本小児血液・がん学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Advanced Surgical Strategy for Giant Mediastinal Germ Cell Tumor in Children.2017

    • Author(s)
      Fumino S, Sakai K, Higashi M, Aoi S, Furukawa T, Yamagishi M, Inoue M, Iehara T, Hosoi H, Tajiri T
    • Organizer
      50th Annual Meeting of the Pacific Association of Pediatric Surgeons
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Direct Conversion of Human Fibroblasts Toward the Myogenic Cell Lineage: The implications of Diaphragmatic Regeneration.2017

    • Author(s)
      Wakao J,Kishida T,Fumino S,Kimura K,Higashi M,Aoi S,Furukawa T,Mazda O,Tajiri T
    • Organizer
      50th Annual Meeting of the Pacific Association of Pediatric Surgeons
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Immunohistochemical analysis of pre- and post-chemotherapeutic ERK phosphorylation in clinical neuroblastoma samples.2017

    • Author(s)
      Tanaka T,Takeuchi Y,Higashi M,Fumino S,Iehara T,Hosoi H,Sakai T,Tajiri T.
    • Organizer
      3rd Asia-Pacific International Symposium of Neuroblastoma,
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Preclinical study of novel MEK inhibitors on neuroblastoma and the biomarker for their therapeutic effects in neuroblastoma xenograft mice.2017

    • Author(s)
      Takeuchi Y, Tanaka T, Higashi M, Fumino S, Iehara T, Hosoi H, Sakai T, Tajiri T.
    • Organizer
      3rd Asia-Pacific International Symposium of Neuroblastoma
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Current surgical intervention for pediatric giant mediastinal germ cell tumors.2017

    • Author(s)
      Fumino S, Sakai K, Higashi M, Aoi S, Furukawa T, Yamagishi M, Inoue M, Iehara T, Hosoi H, Tajiri T
    • Organizer
      49th Congress of the International Society of Paediatric Oncology (SIOP)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 標準小児外科学 第7版 第22章小児腫瘍 B神経芽腫2017

    • Author(s)
      髙松 英夫 田尻達郎
    • Total Pages
      432
    • Publisher
      医学書院
    • ISBN
      9784260027809
    • Related Report
      2017 Research-status Report
  • [Book] 標準小児外科学 第7版 G悪性リンパ腫2017

    • Author(s)
      髙松 英夫 田尻達郎
    • Total Pages
      432
    • Publisher
      医学書院
    • ISBN
      9784260027809
    • Related Report
      2017 Research-status Report
  • [Book] 標準小児外科学 第7版 Iその他の良性腫瘍2017

    • Author(s)
      髙松 英夫 田尻達郎
    • Total Pages
      432
    • Publisher
      医学書院
    • ISBN
      9784260027809
    • Related Report
      2017 Research-status Report
  • [Book] スタンダード小児がん手術 : 臓器別アプローチと手技のポイント2017

    • Author(s)
      田口 智章、黒田 達夫 田尻達郎
    • Total Pages
      313
    • Publisher
      メジカルビュー社
    • ISBN
      9784758304658
    • Related Report
      2017 Research-status Report
  • [Book] Ⅷ.血液,腫瘍 固形腫瘍(神経芽腫)2017

    • Author(s)
      山岸 敬幸 田尻達郎
    • Total Pages
      407
    • Publisher
      診断と治療社
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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