The roles of immune cells in the process of wound healing

Research Project

Project/Area Number	17K11548
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Plastic surgery
Research Institution	Kyorin University
Principal Investigator	Suga Hirotaka 杏林大学, 医学部, 講師 (60633972)
Project Period (FY)	2017-04-01 – 2020-03-31
Project Status	Completed (Fiscal Year 2019)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	創傷治癒 / マクロファージ / 単球・マクロファージ系細胞 / 線維化 / 免疫系細胞 / ノックアウトマウス
Outline of Final Research Achievements	Various kinds of immune cells are involved in the process of wound healing. However, roles of these immune cells have been unclear. Our in vitro study revealed that CD206+ macrophages have antifibrotic effects on fibroblasts via a paracrine mechanism involving IL-6. An increased understanding of these effects, especially in vivo, will help elucidate the mechanism of scar control in wound healing and contribute to the development of new therapies for scars.
Academic Significance and Societal Importance of the Research Achievements	創傷治癒の機序についてはまだ不明な点も多く，ケロイドや肥厚性瘢痕など創傷治癒に関連した疾患に苦しむ患者さんも多い。我々の研究により，マクロファージという免疫系細胞がインターロイキン６というサイトカインの分泌を介して創傷治癒過程の線維化を抑制していることが明らかになった。この結果はケロイドや肥厚性瘢痕の予防や治療につながる可能性がある。