Fundamental Molecular analysis of chronic infection leading to hypertrophic scars and keloids
| Project/Area Number |
17K11560
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
秋田 定伯 福岡大学, 医学部, 教授 (90315250)
高木 誠司 福岡大学, 医学部, 准教授 (30419197)
大山 拓人 福岡大学, 医学部, 講師 (40570809)
自見 至郎 福岡大学, 医学部, 講師 (30226360)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 動物モデル / 肥厚性瘢痕 / 張力 / 創傷治癒 / 肉芽 / 瘢痕 / ケロイド / 筋肉再生 / メカニカルストレス / TGF-β経路 / コラーゲン / 慢性感染 / 続発 / 分子基盤 |
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| Outline of Final Research Achievements |
Scar lesions found in human are scarcely developed in murine. We created a novel model of scar forming wound by resecting a small portion of the rectus abdominis in mice, where muscular tensile force is physically loaded. In 3 weeks after the resection, the lesions with collagen-rich granulations were develop accompanied with multiple nodular lesions that is similar to the hypertrophic scars in human. In conclusion, this novel technique is the first established for the development of hypertrophic scars under a physiological condition in mice. We believe that this model is quite useful to investigate of new drugs for the patients with scar lesions in future.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、生理学的環境下で瘢痕病変を形成できる動物(マウス)モデルを世界で初めて創出できた。このモデルにより、今まで明らかにされていなかった瘢痕病変が主体となる肥厚性瘢痕やケロイドの病態解明につながることが期待できる。また、本モデルを使用することで、治療法の開発などにも活用でき、瘢痕性病変に悩む患者に対し新規治療法の開発につながり、社会的意義も大きい。
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Report
(4 results)
Research Products
(18 results)
