| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Post-cardiac arrest syndrome is considered to be one of the pathologies caused by ischemia-reperfusion injury. Endoplasmic reticulum stress response plays a significant role in this condition, and chemical chaperones have shown effectiveness. The plan was to investigate whether the chaperone 4-PBA could alleviate brain and myocardial injury in a rat asphyxiation model. The study utilized mice that achieved spontaneous cardiac recovery within 3 minutes after confirming cardiac arrest by discontinuing artificial respiration and initiating cardiopulmonary resuscitation. To ensure the survival and quality of the mice, it was crucial to maintain consistency in the chest compression technique, and therefore attempts were made to establish a stable cardiopulmonary arrest and resuscitation model.
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