| Project/Area Number |
17K11582
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Saitama Children's Medical Center (2019)
Yokohama City University (2017-2018) |
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Principal Investigator |
Uchimoto Kazuhiro 埼玉県立小児医療センター (臨床研究部), 集中治療科, 医長 (50710951)
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| Co-Investigator(Kenkyū-buntansha) |
水原 敬洋 横浜市立大学, 附属病院, 講師 (00637712)
東條 健太郎 横浜市立大学, 医学部, 講師 (80737552)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ARDS / 人工呼吸 / 細胞死 / ネクローシス / アポトーシス / 臓器不全 |
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| Outline of Final Research Achievements |
The aim of this proect was investigating the relative contribution of necrosis and apoptosis for the alveolar epithelial cell death in ARDS patients, utilizing CK18-M30 and M65 as markers. We have confirmed the validity of these markers using animal models. However, we could not investigate about the types of alveolar epithelial cell death in human ARDS patients.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によってARDSにおいてBALF中のCK18-M30，およびM65が肺胞上皮細胞死のタイプ特異的なマーカーになりうることが示唆された．しかしながら，実際のARDS患者での検証には至らず，課題が残る結果となった．
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