| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The pituitary adenylate cyclase-activating polypeptide PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) is known to have axon elongation effects on neurons after injury. In the present study, we analyzed the molecular mechanism of PACAP-induced axon elongation in PC12 cells, which are frequently used as a model for axon elongation. It is revealed that PACAP-induced axon elongation was mediated by the activation of Akt by PI3K and the inactivation of GSK-3β by the activation of Akt and the subsequent decrease in the inactive form of phosphorylated CRMP2.
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