Molecular mechanism of neuropotection and axonal elongation by PACAP
| Project/Area Number |
17K11597
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
竹ノ谷 文子 星薬科大学, 薬学部, 准教授 (30234412)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | PACAP / PAC1-R / 虚血 / 神経細胞死 / 軸索伸長 / ノックアウトマウス / CRMP2 / 脊髄損傷 / 神経ペプチド / 脊椎損傷 |
|---|
| Outline of Final Research Achievements |
The pituitary adenylate cyclase-activating polypeptide PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) is known to have axon elongation effects on neurons after injury. In the present study, we analyzed the molecular mechanism of PACAP-induced axon elongation in PC12 cells, which are frequently used as a model for axon elongation. It is revealed that PACAP-induced axon elongation was mediated by the activation of Akt by PI3K and the inactivation of GSK-3β by the activation of Akt and the subsequent decrease in the inactive form of phosphorylated CRMP2.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究ではPACAPによる軸索伸長作用の分子機構の一端を明らかにすることが出来た。さらなる解析が必要であるが、今後詳細な解析を進めることにより、神経損傷後の軸索伸長、神経細胞死抑制における新たな標的分子の発見ができると思われる。その結果、PACAPの虚血に対する救急医療領域での臨床応用への道が開かれるとともに、新規医薬品の開発につながることが期待できる。
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues.2017
Author(s)
Coutinho EA, Okamoto S, Ishikawa AW, Yokota S, Wada N, Hirabayashi T, Saito K, Sato T, Takagi K, Wang CC, Kobayashi K, Ogawa Y, Shioda S, Yoshimura Y, Minokoshi Y
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Journal Title
Diabetes
Volume: 66
Issue: 9
Pages: 2372-2372
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clustered protocadherins are required for building functional neural circuits.2017
Author(s)
Hasegawa S, Kobayashi H, Kumagai M, Nishimaru H, Tarusawa E, Kanda H, Kaneko R, Sanbo M, Yoshimura Y, Hirabayashi M, Hirabayashi T, Yagi T
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Journal Title
Front Mol Neurosci
Volume: 印刷中
Pages: 114-114
DOI
Related Report
Peer Reviewed / Open Access
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[Book] アロマセラピー学2017
Author(s)
竹ノ谷文子、神保太樹、平林敬浩、塩田清二
Total Pages
203
Publisher
悠光堂
ISBN
9784906873746
Related Report
