• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the pre-metastasis niche formation mechanism of oral cancer by TANGO

Research Project

Project/Area Number 17K11621
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphological basic dentistry
Research InstitutionNara Medical University

Principal Investigator

Sasahira Tomoonori  奈良県立医科大学, 医学部, 講師 (90405374)

Co-Investigator(Kenkyū-buntansha) 栗原 都  奈良県立医科大学, 医学部附属病院, 研究員 (40453170)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords口腔癌 / TANGO
Outline of Final Research Achievements

TANGO acts tumor-promotingly in oral cancer. We have conducted detailed studies on the functions and signal pathways of TANGO in oral cancer using clinical specimen and oral cancer cell line. As a result, NCAPH, mast cell chymase, SRPX2, PXDN, MUC20, etc. were newly identified as new molecules related to TANGO. Among these, DHRS9 acts on tumor inhibitory properties in oral cancer, but other molecules act as oncgene in oral cancer. It was also revealed that some of them are detected as secretory proteins not only in tumors but also in serum. It is expected that it may be a molecular marker in oral cancer

Academic Significance and Societal Importance of the Research Achievements

新たに見いだされた因子の多くは口腔癌において腫瘍促進的に作用することより、それらを標的とした分子治療の可能性が期待される。また血中において検出可能な分泌タンパクもいくつか含まれていたことより、検査マーカーとしての応用も考えられる。特に唾液中からも検出されることが明らかになれば、簡便かつ低侵襲な腫瘍マーカー検査が可能になり、ひいては口腔癌の早期発見・治療による予後向上に寄与できるものと期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (11 results)

All 2020 2019 2018 2017

All Journal Article (9 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (2 results)

  • [Journal Article] Sushi repeat containing Protein X-linked 2 Is a downstream signal of LEM domain containing 1 and acts as a2020

    • Author(s)
      Sasahira T, Kurihara-Shimomura M, Nishiguchi Y, Shimomura H, Kirita T
    • Journal Title

      Int J Mol Sci

      Volume: 21 Issue: 10 Pages: 3655-3655

    • DOI

      10.3390/ijms21103655

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Peroxidan plays a tumor-promoting role in oral squamous cell carcinoma2020

    • Author(s)
      Kurihara-Shimomura M, Sasahira T, Shimomura H, Kirita T
    • Journal Title

      Int J Mol

      Volume: 21 Issue: 15 Pages: 5416-5416

    • DOI

      10.3390/ijms21155416

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of oral squamous cell carcinoma markers MUC2 and SPRR1B downstream of TANGO2020

    • Author(s)
      Sasahira T, Kurihara-Shimomura M, Shimomura H, Bosserhoff AK, Kirita T
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 147 Issue: 6 Pages: 1659-1672

    • DOI

      10.1007/s00432-021-03568-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma2019

    • Author(s)
      Kurihara-Shimomura M, Sasahira T, Shimomura H, Bosserhoff AK, Kirita T
    • Journal Title

      Int J Oncol

      Volume: 56 Pages: 1093-1100

    • DOI

      10.3892/ijo.2020.4996

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Non-SMC condensin I complex subunit H (NCAPH) is associated with lymphangiogenesis and drug resistance2019

    • Author(s)
      Shimomura H, Sasahira T, Nakashima C, Kurihara-Shimomura M, Kirita T
    • Journal Title

      J Clin Med

      Volume: 9 Issue: 1 Pages: 72-72

    • DOI

      10.3390/jcm9010072

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma2018

    • Author(s)
      10.1136/jclinpath-2017-204770
    • Journal Title

      J Clin Pathol

      Volume: 71 Issue: 5 Pages: 436-41

    • DOI

      10.1136/jclinpath-2017-204770

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma2018

    • Author(s)
      Sasahira T, Nishiguchi Y, Kurihara-Shimomura M, Nakashima C, Kuniyasu H, Kirita T
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 144 Issue: 5 Pages: 875-882

    • DOI

      10.1007/s00432-018-2612-x

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma2018

    • Author(s)
      Shimomura H, Sasahira T, Nakashima C, Shimomura-Kurihara M, Kirita T
    • Journal Title

      Pathology

      Volume: 50 Issue: 6 Pages: 642-47

    • DOI

      10.1016/j.pathol.2018.06.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The importance of melanoma inhibitory activity gene family in the tumor progression of oral cancer2018

    • Author(s)
      Sasahira T, Bosserhoff AK, Kirita T
    • Journal Title

      The importance of melanoma inhibitory activity gene family in the tumor progression of oral cancer

      Volume: 68 Issue: 5 Pages: 275-286

    • DOI

      10.1111/pin.12672

    • Related Report
      2017 Research-status Report
  • [Presentation] 口腔扁平上皮癌におけるME1発現と腫瘍促進の関係2018

    • Author(s)
      中嶋千恵、山本一彦、谷 里奈、バワール ウジャール、笹平智則、桐田忠昭、國安弘基
    • Organizer
      第77回日本癌学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 中嶋千恵、栗原 都、山本一彦、バワール ウジャール、笹平智則、桐田忠昭、國安弘基2017

    • Author(s)
      Malic enzyme 1 による口腔扁平上皮癌促進作用
    • Organizer
      第76回日本癌学会総会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi